Výsledky vyhledávání - "Natalie Hiscock"

Akademický článek

Relationship between insulin sensitivity and gene expression in human skeletal muscle

Autor: Hemang M. Parikh, Targ Elgzyri, Amra Alibegovic, Natalie Hiscock, Ola Ekström, Karl-Fredrik Eriksson, Allan Vaag, Leif C. Groop, Kristoffer Ström, Ola Hansson

Publikováno v: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-12 (2021)

Abstract Background Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still p

Externí odkaz: https://doaj.org/article/a6ed4a5771f74190b226281bc86d4bb0

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Relationship between insulin sensitivity and gene expression in human skeletal muscle

Autor: Targ Elgzyri, Natalie Hiscock, Leif Groop, Amra Ciric Alibegovic, Hemang Parikh, Ola Ekström, Kristoffer Ström, Karl-Fredrik Eriksson, Ola Hansson, Allan Vaag

Publikováno v: BMC Endocrine Disorders
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-12 (2021)

BackgroundInsulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f7dcd34191a4ea98606a83f0de46b0
https://pubmed.ncbi.nlm.nih.gov/33639916

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Adiponectin concentration is associated with muscle insulin sensitivity, AMPK phosphorylation, and ceramide content in skeletal muscles of men but not women

Autor: Anne-Marie Lundsgaard, Erik A. Richter, Bente Kiens, Andreas Børsting Jordy, Kim A. Sjøberg, Jørgen F. P. Wojtaszewski, Louise D. Høeg, Natalie Hiscock

Publikováno v: Journal of Applied Physiology. 114:592-601

Adiponectin is an adipokine that regulates metabolism and increases insulin sensitivity. Mechanisms behind this insulin-sensitizing effect have been investigated in rodents, but little is known in humans, especially in skeletal muscle. Women have hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325e16de674e3a489b0d353cfb033aa2
https://doi.org/10.1152/japplphysiol.01046.2012

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Muscle Protein Synthetic Responses to Exercise: Effects of Age, Volume, and Intensity

Autor: Debbie Rankin, John P. Williams, Vinod Kumar, Michael J. Rennie, Natalie Hiscock, Kenneth Smith, Anna Selby, Philip J. Atherton

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 67:1170-1177

We explored the relationships between resistance exercise volume/intensity and muscle myofibrillar protein synthetic (MPS) responses in young and older men. In a crossover design, four groups of six young (24±6 years) and older (70±5 years) men per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbfedf2aa0a61f8a5f3d4583343bbd6
https://doi.org/10.1093/gerona/gls141

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Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects

Autor: Stine Jacobsen, David B. Dunger, Charlotte Brøns, Bjørn Quistorff, Emma Nilsson, Andrew White, Arne Astrup, Allan Vaag, Natalie Hiscock

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 302:E43-E51

Low birth weight (LBW) is associated with an increased risk of insulin resistance and downregulation of oxidative phosphorylation (OXPHOS) genes when exposed to a metabolic challenge of high-fat overfeeding (HFO). To elaborate further on the differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c939e5913b42d88d4e91272a9979ecfd
https://doi.org/10.1152/ajpendo.00095.2011

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Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men

Autor: Anna Selby, Natalie Hiscock, Kenneth Smith, Vinod Kumar, Philip J. Atherton, Bethan E. Phillips, Wulf Hildebrandt, John P. Williams, Debbie Rankin

Publikováno v: Clinical nutrition (Edinburgh, Scotland). 36(3)

Maximizing anabolic responses to feeding and exercise is crucial for muscle maintenance and adaptation to exercise training. We hypothesized that enriching a protein drink with leucine would improve anabolic responses to resistance exercise (RE: 6 ×

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b9badc7aac99cef5226b958d11e120
https://pubmed.ncbi.nlm.nih.gov/27208923

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Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men

Autor: Jette Bork-Jensen, Amra Ciric Alibegovic, Natalie Hiscock, Emma Nilsson, Stine Jacobsen, Allan Vaag, Bente Stallknecht, Brynjulf Mortensen, Lise Højbjerre, Kristine Færch, Mette P. Sonne, Flemming Dela, Martin Friedrichsen

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 299:E752-E763

Physical inactivity is a risk factor for insulin resistance. We examined the effect of 9 days of bed rest on basal and insulin-stimulated expression of genes potentially involved in insulin action by applying hypothesis-generating microarray in paral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d91110694a323123cc4520fdc4c0fc
https://doi.org/10.1152/ajpendo.00590.2009

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Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling

Autor: Henriette Pilegaard, Louise D. Høeg, Bruno Bisiani, Kim A. Sjøberg, Jesper B. Birk, Christian Frøsig, Erik A. Richter, Bente Kiens, Jacob Jeppesen, Natalie Hiscock, Jørgen F. P. Wojtaszewski, Thomas E. Jensen

Publikováno v: Diabetes

OBJECTIVE We have previously shown that overnight fasted women have higher insulin-stimulated whole body and leg glucose uptake despite a higher intramyocellular triacylglycerol concentration than men. Women also express higher muscle mRNA levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9365313fb8e94692f52ceeb3310abef
http://europepmc.org/articles/PMC3012198

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Behavioral Neurocardiac Training in Hypertension

Autor: Paula J. Harvey, Maggie H Chen, John S. Floras, Hilde Hendrickx, Robert P. Nolan, Duncan Talbot, Caroline Chessex, Michael Catt, Jonathan J. Powell, Natalie Hiscock, Peter Picton, Markad V. Kamath

Publikováno v: Hypertension. 55:1033-1039

It is not established whether behavioral interventions add benefit to pharmacological therapy for hypertension. We hypothesized that behavioral neurocardiac training (BNT) with heart rate variability biofeedback would reduce blood pressure further by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb81a84c591ca342acf57ae35497315
https://doi.org/10.1161/hypertensionaha.109.146233

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Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men

Autor: Stine Jacobsen, Natalie Hiscock, Bjørn Quistorff, Christine B. Jensen, Andrew White, Emma Nilsson, Arne Astrup, Claus M. Larsen, Charlotte Brøns, Julie Solbjerg Appel, Allan Vaag, Heidi Storgaard

Publikováno v: The Journal of Physiology. 587:2387-2397

A high-fat, high-calorie diet is associated with obesity and type 2 diabetes. However, the relative contribution of metabolic defects to the development of hyperglycaemia and type 2 diabetes is controversial. Accumulation of excess fat in muscle and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd010e702f043c85407bd2dc31a4b87f
https://doi.org/10.1113/jphysiol.2009.169078

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