Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Natalie Herzog"'
Publikováno v:
Cells, Vol 12, Iss 17, p 2140 (2023)
In the liver, phase-1 biotransformation of drugs and other xenobiotics is largely facilitated by enzyme complexes consisting of cytochrome P450 oxidoreductase (CPR) and cytochrome P450 monooxygenases (CYPs). Generated from human liver-derived cell li
Externí odkaz:
https://doaj.org/article/bc79494e051f4242b354ca3984c39aa4
Autor:
Stephan R. Künzel, Johanna S. E. Rausch, Charlotte Schäffer, Maximilian Hoffmann, Karolina Künzel, Erik Klapproth, Theresa Kant, Natalie Herzog, Jan‐Heiner Küpper, Kristina Lorenz, Svenja Dudek, Ramona Emig, Ursula Ravens, Eva A. Rog‐Zielinska, Rémi Peyronnet, Ali El‐Armouche
Publikováno v:
FEBS Open Bio, Vol 10, Iss 7, Pp 1210-1218 (2020)
Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of fibrosis, the knowledge about the underlying mechanisms is limited, which prevents effective pharma
Externí odkaz:
https://doaj.org/article/12b9c704df7c46728a2977c9005cd5a5
Autor:
Andrea Scheffschick, Jonas Babel, Sebastian Sperling, Julia Nerusch, Natalie Herzog, Daniel Seehofer, Georg Damm
Publikováno v:
Biology, Vol 11, Iss 8, p 1195 (2022)
Non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in the liver, is the most common cause of liver diseases in Western countries. NAFLD is a major risk factor for developing hepatocellular carcinoma (HCC); however, in vitr
Externí odkaz:
https://doaj.org/article/84c07c70c4fd40e4aa7ee51f80a809ab
Autor:
Nadine Katzenberger, S. Steinbrecht, Sarah Kammerer, Jan-Heiner Küpper, Nadine Pfeifer, Christian Schulz, Natalie Herzog
Publikováno v:
Toxicology Letters. 319:155-159
Novel HepG2 cell clones 1A2 C2 and 1A2 C7 were independently generated by lentiviral transduction to functionally overexpress cytochrome P450 1A2 (CYP1A2). We found similar and stable CYP1A2 transcript and protein levels in both cell clones leading t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da4f789f82c00634539edfd055eeafe
https://doi.org/10.1016/j.toxlet.2019.11.006
https://doi.org/10.1016/j.toxlet.2019.11.006
Autor:
Andrea Scheffschick, Gerda Schicht, Lena Seidemann, Sebastian Sperling, Julia Nerusch, Natalie Herzog, Jonas Babel, Jan Küpper, Daniel Seehofer, Georg Damm
Publikováno v:
Journal of Hepatology. 77:S658
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f00d107fa28d5fef57c3835f02d5b148
https://doi.org/10.1016/s0168-8278(22)01632-4
https://doi.org/10.1016/s0168-8278(22)01632-4
Autor:
Silvio Weber, Maximilian Hoffmann, Susanne Kämmerer, Molly O’Reilly, Ali El-Armouche, Mirna S. Sadek, Sems Malte Tugtekin, Ben Wielockx, Pauline Wimberger, Mario Günscht, L C Sommerfeld, Natalie Herzog, Ursula Ravens, Larissa Fabritz, Stefan Rose-John, Jan-Heiner Küpper, Kaomei Guan, Erik Klapproth, S. Nashitha Kabir, Tomasz Kolanowski, Jan Dominik Kuhlmann, Michael Wagner, Manuel Mayr, Stefanie Meyer-Roxlau, Stephan R Künzel, Konrad Grützmann, Stanley Nattel, Karolina Künzel, Xiaoke Yin, C. Piorkowski, Johanna S E Rausch, Dobromir Dobrev
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will o
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e048dfbc460665ba37f1c2b2bbe8d1
https://www.ncbi.nlm.nih.gov/pubmed/34433292
https://www.ncbi.nlm.nih.gov/pubmed/34433292
Publikováno v:
Journal of Cellular Biotechnology. 1:183-190
Chronic alcohol abuse is the leading cause of liver cirrhosis in western countries. Ethanol, even at lower concentrations, can cause pleiotropic effects at the cellular level such as the formation of reactive oxygen species (ROS) and DNA damage. Etha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e1da7b9e107e50791db48672435477
https://doi.org/10.3233/jcb-15019
https://doi.org/10.3233/jcb-15019
Autor:
Katrin Scheibner, Sebastian Sperling, Kai-Uwe Schmidtke, Amelie Lupp, Georg Damm, Natalie Herzog, Jan-Heiner Küpper, Ursula Anderer, Daniel Seehofer, Max Hansen, Sebastian Miethbauer
Publikováno v:
Cell Biology International. 40:341-353
Primary human hepatocytes are in great demand during drug development and in hepatology. However, both scarcity of tissue supply and donor variability of primary cells create a need for the development of alternative hepatocyte systems. By using a le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e347c14fb4628f3e3a75f1201924a4
https://doi.org/10.1002/cbin.10574
https://doi.org/10.1002/cbin.10574
Autor:
Konrad Gruetzmann, Jan Dominik Kuhlmann, Manuel Mayr, Susanne Kaemmerer, Sems Malte Tugtekin, Stefan Rose-John, Natalie Herzog, Silvio Weber, Michael Wagner, Stefanie Meyer-Roxlau, Pauline Wimberger, Tomasz Kolanowski, Stephan R. Kuenzel, Karolina Sekeres, Kaomei Guan, Christopher Piorkowski, Ursula Ravens, Jan-Heiner Kuepper, Ali El-Armouche, Xiaoke Yin
Fibrosis and inflammation promote atrial fibrillation (AF) and worsen its clinical outcome. The underlying molecular mechanisms, that are relevant for effective antifibrotic drug development, are still under debate. This study deciphers a novel mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c674a9ab6aace1d5e12c87770ce27019
Autor:
Natalie Herzog, Friedrich Jung, Jan-Heiner Küpper, Anne Krüger-Genge, S. Steinbrecht, Kai-Uwe Schmidtke, Katrin Scheibner, Sarah Kammerer, Rosalie König
Publikováno v:
Toxicology. 412
Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dd374f184acbf777eb991648686cdc
https://pubmed.ncbi.nlm.nih.gov/30500380
https://pubmed.ncbi.nlm.nih.gov/30500380