Inhibition of interferon gamma impairs induction of experimental epidermolysis bullosa acquisita

Autor: Natalie Gross, Jana Marketon, Sadegh Mousavi, Kathrin Kalies, Ralf J. Ludwig, Katja Bieber

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Epidermolysis bullosa acquisita (EBA) is a muco-cutaneous autoimmune disease characterized and caused by autoantibodies targeting type VII collagen (COL7). The treatment of EBA is notoriously difficult, with a median time to remission of 9 months. In

Externí odkaz: https://doaj.org/article/41846c02a8354d299b2bbcda8da55834

Cutaneous kinase activity correlates with treatment outcomes following PI3K delta inhibition in mice with experimental pemphigoid diseases

Autor: Saeedeh Ghorbanalipoor, Shirin Emtenani, Melissa Parker, Mayumi Kamaguchi, Colin Osterloh, Manuela Pigors, Natalie Gross, Stanislav Khil’chenko, Anika Kasprick, Sabrina Patzelt, Diana Wortmann, Ibrahim O. Ibrahim, Kentaro Izumi, Stephanie Goletz, Katharina Boch, Kathrin Kalies, Katja Bieber, Paul Smith, Enno Schmidt, Ralf J. Ludwig

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Chronic blistering at the skin and/or mucous membranes, accompanied by a varying degree of inflammation, is the clinical hallmark of pemphigoid diseases that impose a major medical burden. Pemphigoid diseases are caused by autoantibodies targeting st

Externí odkaz: https://doaj.org/article/c4fc3f38cd5048a4b93212cdf1cf1518

AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9DY atherosclerosis mouse model

Autor: Leonie Achner, Tobias Klersy, Benedikt Fels, Tobias Reinberger, Cosima X. Schmidt, Natalie Groß, Susanne Hille, Oliver J. Müller, Zouhair Aherrahrou, Kristina Kusche-Vihrog, Walter Raasch

Publikováno v: Pflügers Archiv - European Journal of Physiology. 474:993-1002

Investigating atherosclerosis and endothelial dysfunction has mainly become established in genetically modified ApoE−/− or LDL-R−/− mice transgenic models. A new AAV-PCSK9DYDY mouse model with no genetic modification has now been reported as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2a66166b2ae5f65f0cccd51b1698694
https://doi.org/10.1007/s00424-022-02710-x

Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita

Autor: Veronika Hartmann, Martina Behnen-Härer, Nancy Ernst, Gestur Vidarsson, Katja Bieber, Frank Petersen, Ralf Ludwig, Anika Kasprick, Colin Osterloh, Katharina Boch, Tamás Laskay, Michael Radziewitz, Cindy Hass, Natalie Gross, Xinhua Yu, Remco Visser, Hannah Zillikens

Publikováno v: Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine, 8:713312. Frontiers Media S.A.
Frontiers in Medicine, 8, 1. Frontiers Media S.A.
Frontiers in Medicine

Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies. Mechanistically, inhibition of specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec9ee422b26f8e792b270115f960bce
https://www.frontiersin.org/articles/10.3389/fmed.2021.713312/full

Practice patterns for chronic hypoparathyroidism: data from patients and physicians in France

Autor: Jean-Philippe Bertocchio, Natalie Grosset, Lionel Groussin, Peter Kamenický, Fabrice Larceneux, Anne Lienhardt-Roussie, Agnès Linglart, Gérard Maruani, Eric Mirallie, François Pattou, Riyad N H Seervai, Coralie Sido, Caroline Silve, Aurélie Vilfaillot, Antoine Tabarin, Marie-Christine Vantyghem, Pascal Houillier

Publikováno v: Endocrine Connections, Vol 11, Iss 1, Pp 1-11 (2022)

Context: Recent guidelines have provided recommendations for the care of patients with chronic hypoparathyroidism. Very little is known about actual physicians’ practices or their adherence to such guidelines. Objective: To describe the physicians�

Externí odkaz: https://doaj.org/article/bf00ba6ee5f64061ab750abbff025138