Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Natalie G. Lumsden"'
Autor:
Danielle L. Michell, Waled A. Shihata, Karen L. Andrews, Nurul Aisha Zainal Abidin, Ann-Maree Jefferis, Amanda K. Sampson, Natalie G. Lumsden, Olivier Huet, Marie-Odile Parat, Garry L. Jennings, Robert G. Parton, Kevin J. Woollard, David M. Kaye, Jaye P. F. Chin-Dusting, Andrew J. Murphy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The aetiology and progression of hypertension involves various endogenous systems, such as the renin angiotensin system, the sympathetic nervous system, and endothelial dysfunction. Recent data suggest that vascular inflammation may also pla
Externí odkaz:
https://doaj.org/article/89d56ef6af8740c7a60458ad31b61cc1
Autor:
Julia L Jones, Koen Simons, Jo-Anne Manski-Nankervis, Natalie G Lumsden, Sanduni Fernando, Maximilian P de Courten, Nicholas Cox, Peter Shane Hamblin, Edward D Janus, Craig L Nelson
Publikováno v:
Digital Health, Vol 9 (2023)
Background Interrelated chronic vascular diseases (chronic kidney disease (CKD), type 2 diabetes (T2D) and cardiovascular disease (CVD)) are common with high morbidity and mortality. This study aimed to assess if an electronic-technology-based qualit
Externí odkaz:
https://doaj.org/article/ac97c0d8119c4de38a4a297a0965253b
Autor:
Julia L Jones, Natalie G Lumsden, Koen Simons, Anis Ta'eed, Maximilian P de Courten, Tissa Wijeratne, Nicholas Cox, Christopher J A Neil, Jo-Anne Manski-Nankervis, Peter Shane Hamblin, Edward D Janus, Craig L Nelson
Publikováno v:
Family medicine and community health. 10(1)
ObjectivesTo evaluate the capacity of general practice (GP) electronic medical record (EMR) data to assess risk factor detection, disease diagnostic testing, diagnosis, monitoring and pharmacotherapy for the interrelated chronic vascular diseases—c
Autor:
Kevin J Woollard, Natalie G Lumsden, Karen L Andrews, Andrea Aprico, Emma Harris, Jennifer C Irvine, Ann-maree Jefferis, Lu Fang, Peter Kanellakis, Alex Bobik, Jaye P F Chin-Dusting
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97422 (2014)
Soluble P-selectin (sP-selectin), a biomarker of inflammatory related pathologies including cardiovascular and peripheral vascular diseases, also has pro-atherosclerotic effects including the ability to increase leukocyte recruitment and modulate thr
Externí odkaz:
https://doaj.org/article/e69cf60fa3df4e66b1a4614d465c1b7b
Autor:
Ann-Maree Jefferis, Natalie G. Lumsden, Waled A. Shihata, David M. Kaye, Andrew J. Murphy, Marie-Odile Parat, Jaye Chin-Dusting, Amanda K. Sampson, Danielle L. Michell, Olivier Huet, Karen L. Andrews, Nurul Aisha Zainal Abidin, Robert G. Parton, Garry L. Jennings, Kevin J. Woollard
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The aetiology and progression of hypertension involves various endogenous systems, such as the renin angiotensin system, the sympathetic nervous system, and endothelial dysfunction. Recent data suggest that vascular inflammation may also play a key r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e30ef0f36ee731261591c14648a8be
http://hdl.handle.net/10044/1/88879
http://hdl.handle.net/10044/1/88879
Autor:
Grant R Drummond, Jennifer C Irvine, Karen L. Andrews, Jaye Chin-Dusting, Olivier Huet, Chloe Lim, Barbara K Kemp-Harper, Natalie G. Lumsden, Waled A. Shihata, Danielle L. Michell, Amanda K. Sampson
Publikováno v:
Clinical Science. 130:1629-1640
Nitroxyl anion (HNO) donors are currently being assessed for their therapeutic utility in several cardiovascular disorders including heart failure. Here, we examine their effect on factors that precede atherosclerosis including endothelial cell and m
Autor:
Jennifer C Irvine, Olivier Huet, Ulrike Muscha Steckelings, Robert E Widdop, Amanda K. Sampson, Tyrone A. Barnes, Waled A. Shihata, Garry L. Jennings, Thomas Unger, Jaye Chin-Dusting, Natalie G. Lumsden, Dragana Dragoljevic
Publikováno v:
British Journal of Pharmacology. 173:729-740
Background and Purpose Angiotensin AT2 receptors are upregulated in disease states such as atherosclerosis and blockade of the AT2 receptors exacerbates plaque formation. Direct stimulation of these receptors is anti-atherogenic but the mechanisms an
Autor:
Jaye Chin-Dusting, Barbara K Kemp-Harper, Natalie G. Lumsden, Ann-Maree Jefferis, Julie Farry, Karen L. Andrews
Publikováno v:
Clinical Science. 129:179-187
Pre-clinical studies have identified nitroxyl (HNO), the reduced congener of nitric oxide (NO•), as a potent vasodilator which is resistant to tolerance development. The present study explores the efficacy of HNO in human blood vessels and describe
Autor:
Gilles Guillon, Åsa Andersson, Richard J. Lewis, Sébastien Dutertre, Natalie G. Lumsden, Markus Muttenthaler, Daniel E. Croker, Norelle L. Daly, Paul F. Alewood, David J. Craik
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (11), pp.7100-7108. ⟨10.1074/jbc.M706477200⟩
Journal of Biological Chemistry, 2008, 283 (11), pp.7100-7108. ⟨10.1074/jbc.M706477200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (11), pp.7100-7108. ⟨10.1074/jbc.M706477200⟩
Journal of Biological Chemistry, 2008, 283 (11), pp.7100-7108. ⟨10.1074/jbc.M706477200⟩
International audience; We report the discovery of conopressin-T, a novel bioactive peptide isolated from Conus tulipa venom. Conopressin-T belongs to the vasopressin-like peptide family and displays high sequence homology to the mammalian hormone ox
Autor:
Sanjaya Kuruppu, Wayne C. Hodgson, Yajnavalka Banerjee, R. Manjunatha Kini, Natalie G. Lumsden
Publikováno v:
Neuropharmacology. 52:1065-1070
Colubrid snake venoms potentially represent a vast source of novel biological actives and structural motifs owing to their diverse phylogeny. The present study describes the identification of rufoxin, a neurotoxin from the venom of Rhamphiophis oxyrh