Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Natalie F. Shanks"'
Autor:
Nicholas Pena, Tara Richbourg, Claudia P. Gonzalez-Hunt, Rui Qi, Paul Wren, Carrolee Barlow, Natalie F. Shanks, Holly J. Carlisle, Laurie H. Sanders
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Pathogenic mutations in LRRK2 cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in
Externí odkaz:
https://doaj.org/article/04c86851f418476ba1a0c1df027d9486
Autor:
Jeffrey N. Savas, Yi-Zhi Wang, Laura A. DeNardo, Salvador Martinez-Bartolome, Daniel B. McClatchy, Timothy J. Hark, Natalie F. Shanks, Kira A. Cozzolino, Mathieu Lavallée-Adam, Samuel N. Smukowski, Sung Kyu Park, Jeffery W. Kelly, Edward H. Koo, Terunaga Nakagawa, Eliezer Masliah, Anirvan Ghosh, John R. Yates, III
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2614-2627 (2017)
Amyloid beta (Aβ) peptides impair multiple cellular pathways and play a causative role in Alzheimer’s disease (AD) pathology, but how the brain proteome is remodeled by this process is unknown. To identify protein networks associated with AD-like
Externí odkaz:
https://doaj.org/article/3ed0ac7651364a66abb65df3cf5d0391
Autor:
Natalie F. Shanks, Jeffrey N. Savas, Tomohiko Maruo, Ondrej Cais, Atsushi Hirao, Souichi Oe, Anirvan Ghosh, Yasuko Noda, Ingo H. Greger, John R. Yates, III, Terunaga Nakagawa
Publikováno v:
Cell Reports, Vol 1, Iss 6, Pp 590-598 (2012)
AMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can modulate AMPA-R function in specific ways. The combinatorial effects of four GluA subunits
Externí odkaz:
https://doaj.org/article/63bead959daf439e91daf497fc08509a
Autor:
Nicholas Pena, Claudia P. Gonzalez-Hunt, Rui Qi, Carrolee Barlow, Natalie F. Shanks, Holly J. Carlisle, Laurie H. Sanders
Pathogenic mutations inLRRK2cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef34efb569ccbffc275d271bc1d31bc5
https://doi.org/10.1101/2022.11.30.517979
https://doi.org/10.1101/2022.11.30.517979
Autor:
Michisuke Yuzaki, Eriko Miura, Nikolaos Mitakidis, Terunaga Nakagawa, Ingo H. Greger, A. Radu Aricescu, Natalie F. Shanks, Christian Siebold, Junko Motohashi, Ester Behiels, Wataru Kakegawa, Veronica T. Chang, Maxim Rossmann, Kazuhisa Kohda, Jordan E. Clay, Keiko Matsuda, Jonathan Elegheert
Publikováno v:
Science. 353:295-299
Transmitting signals across the synapse Glutamate receptors located on neuronal cells play a role in mediating electrical signals at excitatory synapses. These glutamatergic synapses are extremely important for nearly all cognitive functions. Eleghee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b160044a685647ea3d14b6a5959fdebe
https://doi.org/10.1126/science.aae0104
https://doi.org/10.1126/science.aae0104
Autor:
Samuel N. Smukowski, Salvador Martínez-Bartolomé, Laura A. DeNardo, Timothy J. Hark, Natalie F. Shanks, Eliezer Masliah, Jeffrey N. Savas, John R. Yates, Terunaga Nakagawa, Anirvan Ghosh, Edward H. Koo, Sung Kyu Park, Mathieu Lavallée-Adam, Yi Zhi Wang, Daniel B. McClatchy, Jeffery W. Kelly, Kira A. Cozzolino
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2614-2627 (2017)
SummaryAmyloid beta (Aβ) peptides impair multiple cellular pathways in the brain and play a causative role in Alzheimer’s disease (AD) pathology, but how the brain proteome is remodeled during this process is unknown. To identify new protein netwo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dc31067650f2091f98ab756965c787
https://europepmc.org/articles/PMC5726791/
https://europepmc.org/articles/PMC5726791/
Autor:
Ondrej Cais, Souichi Oe, Natalie F. Shanks, Yasuko Noda, Tomohiko Maruo, Ingo H. Greger, John R. Yates, Atsushi Hirao, Terunaga Nakagawa, Anirvan Ghosh, Jeffrey N. Savas
Publikováno v:
Cell Reports, Vol 1, Iss 6, Pp 590-598 (2012)
SummaryAMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can modulate AMPA-R function in specific ways. The combinatorial effects of four GluA su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed924cd726812b07dbae048c8de79e7
https://doi.org/10.1016/j.celrep.2012.05.004
https://doi.org/10.1016/j.celrep.2012.05.004
Autor:
Ondrej Cais, Elena I. Zaika, Caleigh M. Azumaya, Terunaga Nakagawa, John R. Yates, Natalie F. Shanks, Tomohiko Maruo, Ingo H. Greger, X. Jeffrey N Savas
Cornichon homologs (CNIHs) are AMPA-type glutamate receptor (AMPAR) auxiliary subunits that modulate AMPAR ion channel function and trafficking. Mechanisms underlying this interaction and functional modulation of the receptor complex are currently un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed410f3755abfe69086544859683fb10
https://europepmc.org/articles/PMC4152608/
https://europepmc.org/articles/PMC4152608/
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(7)
Subunit assembly governs regulation of AMPA receptor (AMPA-R) synaptic delivery and determines biophysical parameters of the ion channel. However, little is known about the molecular pathways of this process. Here, we present single-particle EM three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a606fa6f81bd0fb2a5fc16361b502b26
https://pubmed.ncbi.nlm.nih.gov/20164357
https://pubmed.ncbi.nlm.nih.gov/20164357