The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains

Autor: Shilpi Kalra, Daniel A. Starr, Leslie A Guerrero, Natalie E. Cain, Hongyan Hao, Laura E Jameson, Jessica Bolivar

Publikováno v: eLife, Vol 10 (2021)

KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of linker of nucleoskeleton and cytoskeleton (LINC) complexes that connect nuclei to the cytoskeleton. Caenorhabditis elegans ANC-1, an ortholog of Nesprin-1/2, contains actin-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dc98a25ba37fbb4c251a8916e9d56b
https://elifesciences.org/articles/61069

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning inC. eleganswithout its KASH or actin-binding domains

Autor: Shilpi Kalra, Jessica Bolivar, Laura E Jameson, Hongyan Hao, Daniel A. Starr, Natalie E. Cain, Leslie A Guerrero

KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton.Caenorhabditis elegansANC-1, an ortholog of Nesprin-1/2, contains actin-binding and KASH domains at opposite ends of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25b19c183cc7a033f00d5452171c0ad5
https://doi.org/10.1101/2020.07.14.202838

Genetic Analysis of Nuclear Migration and Anchorage to Study LINC Complexes During Development of Caenorhabditis elegans

Autor: Natalie E. Cain, Daniel A. Starr, James N Brandt, Greg J. Hermann, Leslie A Herrera, Heidi N. Fridolfsson

Publikováno v: The LINC Complex ISBN: 9781493986903

Studying nuclear positioning in developing tissues of the model nematode Caenorhabditis elegans greatly contributed to the discovery of SUN and KASH proteins and the formation of the LINC model. Such studies continue to make important contributions i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6539beef33da1d3bca10b63740f4cd43
https://doi.org/10.1007/978-1-4939-8691-0_13

Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells

Autor: Shaun P. Murphy, Courtney R. Bone, Daniel A. Starr, Natalie E. Cain, Yu-Tai Chang

Publikováno v: Development.

Cellular migrations through constricted spaces are a crucial aspect of many developmental and disease processes including hematopoiesis, inflammation and metastasis. A limiting factor in these events is nuclear deformation. Here, we establish an in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6416a94ad21e6c8cf97c87d906f481a
https://doi.org/10.1242/dev.141192

Conserved SUN-KASH Interfaces Mediate LINC Complex-Dependent Nuclear Movement and Positioning

Autor: Nathan J. Harris, Amy Schoenhofen, Baila Elkin, Natalie E. Cain, Brian M. Woolums, Hongyan Hao, Daniel A. Starr, Zeinab Jahed, Venecia A. Valdez, Leslie A Herrera, G. W. Gant Luxton, Mohammad R. K. Mofrad

Publikováno v: Current biology : CB, vol 28, iss 19
Cain, NE; Jahed, Z; Schoenhofen, A; Valdez, VA; Elkin, B; Hao, H; et al.(2018). Conserved SUN-KASH Interfaces Mediate LINC Complex-Dependent Nuclear Movement and Positioning. Current Biology, 28(19), 3086-3097.e4. doi: 10.1016/j.cub.2018.08.001. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4d50b0dp

© 2018 Elsevier Ltd Many nuclear positioning events involve linker of nucleoskeleton and cytoskeleton (LINC) complexes, which transmit forces generated by the cytoskeleton across the nuclear envelope. LINC complexes are formed by trans-luminal inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac5f06c3643f1d6af5dc450ed2b99e2
https://doi.org/10.1016/j.cub.2018.08.001