Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Natalie E Farrawell"'
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 10, Pp 2218-2220 (2022)
Externí odkaz:
https://doaj.org/article/12ca6c7de35344cfb1c363549a062092
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130036 (2015)
Alpha-2-macroglobulin is an abundant secreted protein that is of particular interest because of its diverse ligand binding profile and multifunctional nature, which includes roles as a protease inhibitor and as a molecular chaperone. The activities o
Externí odkaz:
https://doaj.org/article/589d9da82f1d412998bcdddb1a1bcb58
Autor:
Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Luke McAlary, Diane Ly, Christen G. Chisholm, Josh Snow, Kara L. Vine, Tim Karl, Fabian Kreilaus, Lachlan E. McInnes, Sara Nikseresht, Paul S. Donnelly, Peter J. Crouch, Justin J. Yerbury
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The synthetic copper-containing compound, CuATSM, has emerged as one of the most promising drug candidates developed for the treatment of amyotrophic lateral sclerosis (ALS). Multiple studies have reported CuATSM treatment provides therapeut
Externí odkaz:
https://doaj.org/article/c146cd7fdab24b4d90091d3aa58e739c
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
SOD1 mutations account for ∼20% of familial amyotrophic lateral sclerosis (ALS) cases in which the hallmark pathological feature is insoluble SOD1 aggregates within motor neurons. Here, we investigated the degradation and synthesis of mutant SOD1 t
Externí odkaz:
https://doaj.org/article/cb509023f6e049ed9739bbae0164f696
Autor:
Natalie E Farrawell, Monique Bax, Luke McAlary, Jessie McKenna, Simon Maksour, Dzung Do-Ha, Stephanie L Rayner, Ian P Blair, Roger S Chung, Justin J Yerbury, Lezanne Ooi, Darren N Saunders
Publikováno v:
Human Molecular Genetics.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that share pathological features, including the aberrant accumulation of ubiquitinated protein inclusions within motor neurons. Previously, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250022409eefdc6a3a11d8a4478977ba
https://doi.org/10.1093/hmg/ddad063
https://doi.org/10.1093/hmg/ddad063
Publikováno v:
ACS chemical neuroscience. 13(16)
CuATSM has repeatedly demonstrated to be therapeutically effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743c6de0b1783f1f77f6b02fc92ef5c7
https://pubmed.ncbi.nlm.nih.gov/35900338
https://pubmed.ncbi.nlm.nih.gov/35900338
Publikováno v:
Trends in Neurosciences. 43:274-284
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease but currently has no effective treatment. Growing evidence suggests that proteome homeostasis underlies ALS pathogenesis. Protein production, trafficking, and degradation all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2a3bf25e8c3710e6fd455035130430
https://doi.org/10.1016/j.tins.2020.03.002
https://doi.org/10.1016/j.tins.2020.03.002
Autor:
Stephanie L, Rayner, Shu, Yang, Natalie E, Farrawell, Cyril J, Jagaraj, Flora, Cheng, Jennilee M, Davidson, Luan, Luu, Alberto G, Redondo, Alberto, Rábano, Daniel, Borrego-Hernández, Julie D, Atkin, Marco, Morsch, Ian P, Blair, Justin J, Yerbury, Roger, Chung, Albert, Lee
Publikováno v:
Neurobiology of disease. 167
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with shared pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e72d8deb5d2b5daaea902176a491f0e
https://pubmed.ncbi.nlm.nih.gov/35231559
https://pubmed.ncbi.nlm.nih.gov/35231559
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience, Vol 14 (2021)
SOD1 mutations account for ∼20% of familial amyotrophic lateral sclerosis (ALS) cases in which the hallmark pathological feature is insoluble SOD1 aggregates within motor neurons. Here, we investigated the degradation and synthesis of mutant SOD1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6324383aa8f9c04e5b790af47234ee
https://pubmed.ncbi.nlm.nih.gov/34803609
https://pubmed.ncbi.nlm.nih.gov/34803609
Autor:
Lachlan E. McInnes, Sara Nikseresht, Kara L. Vine, Fabian Kreilaus, Paul S. Donnelly, Josh Snow, Tim Karl, Luke McAlary, Natalie E. Farrawell, Mikayla L. Brown, Jeremy S. Lum, Diane Ly, Justin J. Yerbury, Peter J. Crouch, Christen G. Chisholm
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
The synthetic copper-containing compound, CuATSM, has emerged as one of the most promising drug candidates developed for the treatment of amyotrophic lateral sclerosis (ALS). Multiple studies have reported CuATSM treatment provides therapeutic effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f43f985c2a6fbc6cc4ccd1e17d749a
http://europepmc.org/articles/PMC8481268
http://europepmc.org/articles/PMC8481268