Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Natalie Charitakis"'
Autor:
Natalie Charitakis, Agus Salim, Adam T. Piers, Kevin I. Watt, Enzo R. Porrello, David A. Elliott, Mirana Ramialison
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Identifying spatially variable genes (SVGs) is a key step in the analysis of spatially resolved transcriptomics data. SVGs provide biological insights by defining transcriptomic differences within tissues, which was previously unachievable u
Externí odkaz:
https://doaj.org/article/1b4f8dd834724091bdaa2bce84d5993b
Autor:
Ziyin Xin, Yujun Cai, Louis T. Dang, Hannah M. S. Burke, Jerico Revote, Natalie Charitakis, Denis Bienroth, Hieu T. Nim, Yuan-Fang Li, Mirana Ramialison
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Gene ontology (GO) enrichment analysis is frequently undertaken during exploration of various -omics data sets. Despite the wide array of tools available to biologists to perform this analysis, meaningful visualisation of the over
Externí odkaz:
https://doaj.org/article/8739798a1ad5411a83830f52ed6d44a8
Autor:
Hieu T. Nim, Louis Dang, Harshini Thiyagarajah, Daniel Bakopoulos, Michael See, Natalie Charitakis, Tennille Sibbritt, Michael P. Eichenlaub, Stuart K. Archer, Nicolas Fossat, Richard E. Burke, Patrick P. L. Tam, Coral G. Warr, Travis K. Johnson, Mirana Ramialison
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Congenital heart diseases are the major cause of death in newborns, but the genetic etiology of this developmental disorder is not fully known. The conventional approach to identify the disease-causing genes focuses on screening g
Externí odkaz:
https://doaj.org/article/b9ab3ed0c9654b1f902b20578e0de93f
Autor:
James W. McNamara, Benjamin L. Parker, Holly K. Voges, Neda R. Mehdiabadi, Francesca Bolk, Feroz Ahmad, Jin D. Chung, Natalie Charitakis, Jeffrey Molendijk, Antonia T. L. Zech, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L. Pointer, Petros Syrris, Luis R. Lopes, Perry M. Elliott, Gordon S. Lynch, Richard J. Mills, James E. Hudson, Kevin I. Watt, Enzo R. Porrello, David A. Elliott
Publikováno v:
Nature Cardiovascular Research. 2:159-173
Muscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of muscle function, the identification of regulatory kinases is important for understanding sarcomere biology. Pathogenic variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2ed3835a2586dc599872e642de7334
https://doi.org/10.1038/s44161-023-00219-9
https://doi.org/10.1038/s44161-023-00219-9
Autor:
Hannah Maude, Mira Davidson, Natalie Charitakis, Leo Diaz, William H. T. Bowers, Eva Gradovich, Toby Andrew, Derek Huntley
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Homology between mitochondrial DNA (mtDNA) and nuclear DNA of mitochondrial origin (nuMTs) causes confounding when aligning short sequence reads to the reference human genome, as the true sequence origin cannot be determined. Using a systematic in si
Externí odkaz:
https://doaj.org/article/fb8839994eed4f119d8981c64a7487ce
Autor:
Denis Bienroth, Natalie Charitakis, Sabrina Jaeger-Honz, Dimitar Garkov, David A. Elliott, Enzo R. Porrello, Karsten Klein, Hieu T. Nim, Falk Schreiber, Mirana Ramialison
Spatially resolved transcriptomics (SRT) technologies produce complex, multi-dimensional data sets of gene expression information that can be obtained at subcellular spatial resolution. While several computational tools are available to process and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d40caddc5177bf9ba6569640c67de42
https://doi.org/10.1101/2023.03.31.535025
https://doi.org/10.1101/2023.03.31.535025
Autor:
Natalie Charitakis, Agus Salim, Adam T. Piers, Kevin I. Watt, Enzo R. Porrello, David A. Elliott, Mirana Ramialison
Identifying spatially variable genes (SVGs) is a key step in the analysis of spatially resolved transcriptomics (SRT) data. SVGs provide biological insights by defining transcriptomic differences within tissues, which was previously unachievable usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86547c884e88b6f21d20a9b338f85826
https://doi.org/10.1101/2022.10.31.514623
https://doi.org/10.1101/2022.10.31.514623
Autor:
Rajeev Rudraraju, Matthew J Gartner, Jessica A. Neil, Elizabeth S. Stout, Joseph Chen, Elise J. Needham, Michael See, Charley Mackenzie-Kludas, Leo Yi Yang Lee, Mingyang Wang, Hayley Pointer, Kathy Karavendzas, Dad Abu-Bonsrah, Damien Drew, Yu Bo Yang Sun, Jia Ping Tan, Guizhi Sun, Abbas Salavaty, Natalie Charitakis, Hieu T. Nim, Peter D Currie, Wai-Hong Tham, Enzo Porrello, Jose Polo, Sean J. Humphrey, Mirana Ramialison, David A. Elliott, Kanta Subbarao
Publikováno v:
bioRxiv
SARS-CoV-2 primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe COVID-19. To elucidate molecular mechanisms in the lung and heart, we conducted paired experiments in human stem cell-derived lung alveolar ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6b0b7a8604ed01d26b6e0a794a78c6
https://europepmc.org/articles/PMC9516846/
https://europepmc.org/articles/PMC9516846/
Autor:
James W. McNamara, Benjamin L. Parker, Holly K. Voges, Neda R. Mehdiabadi, Francesca Bolk, Jin D. Chung, Natalie Charitakis, Jeffrey Molendijk, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L. Pointer, Petros Syrris, Luis R. Lopes, Perry M. Elliott, Gordon S. Lynch, Richard J. Mills, James E. Hudson, Kevin I. Watt, Enzo R. Porrello, David A Elliott
SUMMARYPathogenic variants in alpha kinase 3 (ALPK3) cause cardiomyopathy and musculoskeletal disease. How ALPK3 mutations result in disease remains unclear because little is known about this atypical kinase. Using a suite of engineered human pluripo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b35dfde7b5c315eac26da9effbbf008a
https://doi.org/10.1101/2022.09.01.506029
https://doi.org/10.1101/2022.09.01.506029
Autor:
Mirana Ramialison, Mauro W. Costa, Nadia Rosenthal, Enzo R. Porrello, Céline Vivien, Fernando J. Rossello, Milena B. Furtado, Natalie Charitakis, Andrew J. Perry, Monika Mohenska, Denis Bienroth, Jessica Hatwell-Humble, Jose M. Polo, Karel van Duijvenboden, Yuan M.M. Ji, Nathalia M. Tan, Gonzalo del Monte-Nieto, Susan K. Nilsson, Hieu T. Nim, David R. Powell, David A. Elliott, Alex Tokolyi, Anja S Knaupp, Francesca Bolk
Publikováno v:
Journal of molecular and cellular cardiology, 163, 20-32. Academic Press Inc.
Understanding the spatial gene expression and regulation in the heart is key to uncovering its developmental and physiological processes, during homeostasis and disease. Numerous techniques exist to gain gene expression and regulation information in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910e8862570e8d227d6125f8c7e303f6
https://pure.amc.nl/en/publications/3dcardiomics(0e492cd4-bee7-4821-879e-8c9000618ccb).html
https://pure.amc.nl/en/publications/3dcardiomics(0e492cd4-bee7-4821-879e-8c9000618ccb).html