Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Autor: Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal

Externí odkaz: https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e

Accelerating functional gene discovery in osteoarthritis

Autor: Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and aft

Externí odkaz: https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc

Functional validation of the osteoporosis GWAS candidate FUBP3 in knockout mice

Autor: Laura Watts, Bernard Freudenthal, Natalie C. Butterfield, Andrea Pollard, Davide Komla-Ebri, Victoria Leitch, John Logan, Naila Mannan, J.H. Duncan Bassett, Graham R. Williams

Publikováno v: Bone Reports, Vol 13, Iss , Pp 100554- (2020)

Externí odkaz: https://doaj.org/article/0ed941394d2e47659a885794e8921cae

Pitx1 determines characteristic hindlimb morphologies in cartilage micromass culture.

Autor: Natalie C Butterfield, Chen Qian, Malcolm P O Logan

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180453 (2017)

The shapes of homologous skeletal elements in the vertebrate forelimb and hindlimb are distinct, with each element exquisitely adapted to their divergent functions. Many of the signals and signalling pathways responsible for patterning the developing

Externí odkaz: https://doaj.org/article/3010290347fc4147bb37c5f58c0aa88b

Pregnancy and lactation, a challenge for the skeleton

Autor: Graziana Colaianni, Natalie C. Butterfield, Melanie Haffner-Luntzer, Annegreet G. Veldhuis-Vlug, Elizabeth M. Winter, Ling Oei, Nicolas Bonnet, Alex Ireland, Marie-Noëlle Horcajada

Publikováno v: Endocrine Connections, 9(6), R143-R157. Bioscientifica Ltd
Endocrine Connections, 9(6), R143-R157. BIOSCIENTIFICA LTD
Endocrine Connections
Endocrine Connections, Vol 9, Iss 6, Pp R143-R157 (2020)

In this review we discuss skeletal adaptations to the demanding situation of pregnancy and lactation. Calcium demands are increased during pregnancy and lactation, and this is effectuated by a complex series of hormonal changes. The changes in bone s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61f9177c21ae2b476eea80006c15e1a
https://doi.org/10.1530/ec-20-0055