Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Natalie C J Strynadka"'
Autor:
Solmaz Sobhanifar, Liam J Worrall, Dustin T King, Gregory A Wasney, Lars Baumann, Robert T Gale, Michael Nosella, Eric D Brown, Stephen G Withers, Natalie C J Strynadka
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006067 (2016)
In recent years, there has been a growing interest in teichoic acids as targets for antibiotic drug design against major clinical pathogens such as Staphylococcus aureus, reflecting the disquieting increase in antibiotic resistance and the historical
Externí odkaz:
https://doaj.org/article/5145b8a01c064e478e04e7f807981379
Autor:
Julien R C Bergeron, Liam J Worrall, Nikolaos G Sgourakis, Frank DiMaio, Richard A Pfuetzner, Heather B Felise, Marija Vuckovic, Angel C Yu, Samuel I Miller, David Baker, Natalie C J Strynadka
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003307 (2013)
The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of virulence effectors into host cells. It is composed of a "basal body", a lock-nut structure spanning bo
Externí odkaz:
https://doaj.org/article/4db4112da9e849c689b527d13a3699fa
Autor:
Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel c
Externí odkaz:
https://doaj.org/article/af2615cbac4f4e1583d54bc3e7ff1625
Autor:
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cyt
Externí odkaz:
https://doaj.org/article/8a871ad93e594eeba832492229b1329b
Autor:
Jaeyong Lee, Calem Kenward, Liam J. Worrall, Marija Vuckovic, Francesco Gentile, Anh-Tien Ton, Myles Ng, Artem Cherkasov, Natalie C. J. Strynadka, Mark Paetzel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The SARS-CoV-2 protease Mpro is essential for viral replication. Here, the authors have determined the structures of Mpro in complex with 10 of the 11 viral cleavage sequences including a covalent acyl-enzyme intermediate, providing mechanistic and s
Externí odkaz:
https://doaj.org/article/1bd44754c8b142a281ac22dd1d9222a1
Autor:
Olivia Garland, Anh-Tien Ton, Shoeib Moradi, Jason R. Smith, Suzana Kovacic, Kurtis Ng, Mohit Pandey, Fuqiang Ban, Jaeyong Lee, Marija Vuckovic, Liam J. Worrall, Robert N. Young, Ralph Pantophlet, Natalie C. J. Strynadka, Artem Cherkasov
Publikováno v:
Journal of Chemical Information and Modeling. 63:2158-2169
Autor:
J. Andrew N. Alexander, Liam J. Worrall, Jinhong Hu, Marija Vuckovic, Nidhi Satishkumar, Raymond Poon, Solmaz Sobhanifar, Federico I. Rosell, Joshua Jenkins, Daniel Chiang, Wesley A. Mosimann, Henry F. Chambers, Mark Paetzel, Som S. Chatterjee, Natalie C. J. Strynadka
Publikováno v:
Nature. 613:375-382
Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global healthcare burden1,2. In clinical strains, resistance is largely controlled by BlaR13, a receptor that senses β-lactams through the acylation of its sensor domain, i
Autor:
Satish R. Malwal, Ben Mazurek, Jihee Ko, Pujun Xie, Chikako Barnes, Christine Varvitsiotis, Matthew D. Zimmerman, Samir Olatunji, Jaeyong Lee, Min Xie, Jansy Sarathy, Martin Caffrey, Natalie C. J. Strynadka, Véronique Dartois, Thomas Dick, Bom Nae Rin Lee, David G. Russell, Eric Oldfield
Publikováno v:
Journal of Medicinal Chemistry.
Autor:
Phillip M. Danby, Andrew Jeong, Lyann Sim, Ryan P. Sweeney, Jacob F. Wardman, Ryan Karimi, Andreas Geissner, Liam J. Worrall, Jolene. P. Reid, Natalie C. J. Strynadka, Stephen G. Withers
Publikováno v:
Angewandte Chemie International Edition. 62
Autor:
Jonathan Day, Sara S. El Zahed, Chris Bon, Natalie C. J. Strynadka, Michael G. Organ, Eric D. Brown, Maya A. Farha, Sean D. Workman
Publikováno v:
Journal of Medicinal Chemistry. 64:13540-13550
The polyprenyl lipid undecaprenyl phosphate (C55P) is the universal carrier lipid for the biosynthesis of bacterial cell wall polymers. C55P is synthesized in its pyrophosphate form by undecaprenyl pyrophosphate synthase (UppS), an essential cis-pren