PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

Autor: Dustin J Little, Roland Pfoh, François Le Mauff, Natalie C Bamford, Christina Notte, Perrin Baker, Manita Guragain, Howard Robinson, Gerald B Pier, Mark Nitz, Rajendar Deora, Donald C Sheppard, P Lynne Howell

Publikováno v: PLoS Pathogens, Vol 14, Iss 4, p e1006998 (2018)

Poly-β(1,6)-N-acetyl-D-glucosamine (PNAG) is a major biofilm component of many pathogenic bacteria. The production, modification, and export of PNAG in Escherichia coli and Bordetella species require the protein products encoded by the pgaABCD opero

Externí odkaz: https://doaj.org/article/eb91361e84b14e24a860218a28db4e5a

Bacillus subtilis biofilm formation and social interactions

Autor: Sofia Arnaouteli, Nicola R. Stanley-Wall, Ákos T. Kovács, Natalie C. Bamford

Publikováno v: Arnaouteli, S, Bamford, N C, Stanley-Wall, N R & Kovács, Á T 2021, ' Bacillus subtilis biofilm formation and social interactions ', Nature Reviews. Microbiology, vol. 19, pp. 600-614 . https://doi.org/10.1038/s41579-021-00540-9

Biofilm formation is a process in which microbial cells aggregate to form collectives that are embedded in a self-produced extracellular matrix. Bacillus subtilis is a Gram-positive bacterium that is used to dissect the mechanisms controlling matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980a116403f7186a5c8119c7cae66115
https://doi.org/10.1038/s41579-021-00540-9

The majority of the matrix protein TapA is dispensable forBacillus subtiliscolony biofilm architecture

Autor: Michael Porter, Nicola R. Stanley-Wall, Cait E. MacPhee, Sofia Arnaouteli, Tetyana Sukhodub, Natalie C. Bamford, Chris Earl

Publikováno v: Molecular Microbiology. 114:920-933

Biofilm formation is a co-operative behaviour, where microbial cells become embedded in an extracellular matrix. This biomolecular matrix helps manifest the beneficial or detrimental outcome mediated by the collective of cells. Bacillus subtilis is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52accc9ebe9ad43c73f9ad14b1838ee1
https://doi.org/10.1111/mmi.14559

Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis

Autor: Melanie Lehoux, Perrin Baker, Natalie C. Bamford, Donald C. Sheppard, Caitlin A. Zacharias, Fabrice N. Gravelat, P. Lynne Howell, Ira Lacdao, Hanna Ostapska, Deepa Raju, Piyanka Sivarajah, Stephanie Gilbert, Thi Tuyet Mai Nguyen

Publikováno v: mBio, Vol 12, Iss 5 (2021)
mBio

Aspergillus fumigatus is a ubiquitous mold that can cause invasive pulmonary infections in immunocompromised patients. Within the lung, A. fumigatus forms biofilms that can enhance resistance to antifungals and immune defenses. Aspergillus biofilm fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f4f98fd177027883f91c47f296c928
https://doi.org/10.1128/mbio.02446-21

Ega 3 from the fungal pathogen Asperfillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbialbiofilms

Autor: Yongzhen Zhang, Mark Nitz, François Le Mauff, Jeroen D. C. Codée, Caitlin A. Zacharias, Claudia Millán, Donald C. Sheppard, Patrick Yip, Natalie C. Bamford, Isabel Usón, P. Lynne Howell, Adithya S. Subramanian, Adam Forman

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 294(37), 13833-13849

Aspergillus fumigatus is an opportunistic fungal pathogen that causes both chronic and acute invasive infections. Galactosaminogalactan (GAG) is an integral component of the A. fumigatus biofilm matrix and a key virulence factor. GAG is a heterogeneo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d809ff0a54948a7b59fa0bfbbf4f9d63
https://hdl.handle.net/1887/79805