Výsledky vyhledávání - "Natalie C, Twine"

Akademický článek

Neuropilin-1 drives tumor-specific uptake of chlorotoxin

Autor: Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto

Publikováno v: Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-14 (2019)

Abstract Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging a

Externí odkaz: https://doaj.org/article/0260063af8414162a61d45c6971191f1

Zobrazit plný text záznamu

Plný text ve formátu HTML

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling

Autor: Kenichi Nomoto, Kuan-Chun Huang, Donna Kolber-Simonds, Natalie C. Twine, George A. Moniz, Paul Chang, Jue-lon Shie, Jingzang Tao Miu, Karen Ackermann, Zhihong Chen, Sharon McGonigle, Jiayi Wu

Publikováno v: Oncotarget
Impact Journals/National Center for Biotechnology Information (U.S.)

Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. Here, we describe the development of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e06e5b24d95dc69ae605cc8d13662cf
https://doi.org/10.18632/oncotarget.5846

Zobrazit plný text záznamu

EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity

Autor: Renee Wright-Michaud, Sarah Leacu, Jiayi Wu, Xingfeng Bao, Diana I. Albu, Mary Woodall-Jappe, Galina Kuznetsov, Diana Liu, Zichun Wang, Namita Kumar, Natalie C. Twine, Qian Chen, Lana Parent, Christy Ingersoll, Wanjun Zheng, Winnie Lee, Kenichi Nomoto, Kuan-Chun Huang

Publikováno v: OncoImmunology, Vol 6, Iss 8 (2017)
Oncoimmunology

Reprogramming of immunosuppressive tumor microenvironment (TME) by targeting alternatively activated tumor associated macrophages (M2TAM), myeloid-derived suppressor cells (MDSC), and regulatory T cells (Tregs), represents a promising strategy for de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b5d4afc028703d75f3cd8e43ca7f35
https://doaj.org/article/0ad9b21d212e459193839200090fcdbd

Zobrazit plný text záznamu

Gene Expression Analyses Support Fallopian Tube Epithelium as the Cell of Origin of Epithelial Ovarian Cancer

Autor: Elizabeth B. Somers, Zoltan Dezso, Natalie C. Twine, Daniel J. O'Shannessy, Bryan E Hoffman, Sergei Agoulnik, Stephen M. Jackson

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 13687-13703 (2013)
International Journal of Molecular Sciences; Volume 14; Issue 7; Pages: 13687-13703
International Journal of Molecular Sciences

Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous histotype. Further, while dysregulation of the folate-dependent 1-carbon cycle has been implicated in tumorogenesis, little i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d129a082d99723e58915696023751c
http://www.mdpi.com/1422-0067/14/7/13687

Zobrazit plný text záznamu

Combination of EP4 antagonist and checkpoint inhibitors promotes anti-tumor effector T cells in preclinical tumor models

Autor: Diana I. Albu, Mary Woodall-Jappe, Natalie C. Twine, Xingfeng Bao, Kuan-Chun Huang, Jiayi Wu, Kenichi Nomoto

Publikováno v: Journal for Immunotherapy of Cancer

Meeting abstracts Immunotherapies targeting the immune checkpoint receptors have shown great promise for a subset of cancer patients. However, robust and safe combination therapies are still needed to increase the benefit of cancer immunotherapy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42dfeca48546b1d458fab424d60b1373
https://doi.org/10.1186/2051-1426-3-s2-p350

Zobrazit plný text záznamu

Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Autor: Janice P. Dutcher, Fred Immermann, Donna K. Slonim, Andrew J. Dorner, Manuel Hidalgo, William L. Trepicchio, Bonnie Marshall, Theodore F. Logan, Gary Dukart, Andrew Strahs, Michael E. Burczynski, Walter M. Stadler, Gary R. Hudes, Natalie C. Twine

Publikováno v: Clinical Cancer Research. 11:1181-1189

Purpose: Given their accessibility, surrogate tissues, such as peripheral blood mononuclear cells (PBMC), may provide potential predictive biomarkers in clinical pharmacogenomic studies. In leukemias and lymphomas, the prognostic value of peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d38dfc8aa64471578daaa39c4cf4d6
https://doi.org/10.1158/1078-0432.1181.11.3

Zobrazit plný text záznamu

Population pharmacokinetics of CCI-779: Correlations to safety and pharmacogenomic responses in patients with advanced renal cancer

Autor: Cathie Leister, Joseph Boni, Gregor Bender, Fred Immermann, Natalie C. Twine, Virginia Fitzpatrick, Michael E. Burczynski, Jennifer Ann Stover, Andrew J. Dorner

Publikováno v: Clinical Pharmacology & Therapeutics. 77:76-89

Objective Our objective was to estimate the pharmacokinetic parameters of CCI-779 and its metabolite, sirolimus, and evaluate associations of exposure parameters with safety and clinical activity. Exposure parameters were also correlated with pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d363fe933af592035c26ef5b21c7ae2
https://doi.org/10.1016/j.clpt.2004.08.025

Zobrazit plný text záznamu

Abstract P5-06-03: Combination of the PARP inhibitor E7449 with eribulin +/- carboplatin in preclinical models of triple negative breast cancer

Autor: Zoltan Dezso, Mary Woodall-Jappe, Jue-lon Shie, Galina Kuznetsov, Noel Taylor, Shannon McGrath, Sergei Agoulnik, Sharon McGonigle, Natalie C. Twine, Jiayi Wu, Shanqin Xu, Donna Kolber-Simonds, Kenichi Nomoto, Mark Matijevic

Publikováno v: Cancer Research. 75:P5-06

Introduction: In a small neoadjuvant study in patients with triple negative breast cancer (TNBC) the combination of eribulin plus carboplatin was effective, with a pathologic complete response rate of 43% following 4 cycles of treatment. Significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::453c0bd2b328626a8a87c910d6e879a9
https://doi.org/10.1158/1538-7445.sabcs14-p5-06-03

Zobrazit plný text záznamu

Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo

Publikováno v: Molecular pharmacology. 85(3)

The discovery that circulating nucleic acid-containing complexes in the serum of autoimmune lupus patients can stimulate B cells and plasmacytoid dendritic cells via Toll-like receptors 7 and 9 suggested that agents that block these receptors might b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3113cfadd218f07cee055c8fda2a54
https://pubmed.ncbi.nlm.nih.gov/24342772

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání