Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Natalie Bratcher"'
Autor:
Brian R. Berridge, Szczepan W. Baran, Vivek Kumar, Natalie Bratcher-Petersen, Michael Ellis, Chang-Ning Liu, Timothy L. Robertson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Though the portfolio of medicines that are extending and improving the lives of patients continues to grow, drug discovery and development remains a challenging business on its best day. Safety liabilities are a significant contributor to development
Externí odkaz:
https://doaj.org/article/ad27030667f84b9e82a29fe81d79692c
Autor:
Szczepan W. Baran, Natalie Bratcher, John Dennis, Stefano Gaburro, Eleanor M. Karlsson, Sean Maguire, Paul Makidon, Lucas P. J. J. Noldus, Yohann Potier, Giorgio Rosati, Matt Ruiter, Laura Schaevitz, Patrick Sweeney, Megan R. LaFollette
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2022)
In drug discovery and development, traditional assessment of human patients and preclinical subjects occurs at limited time points in potentially stressful surroundings (i.e., the clinic or a test arena), which can impact data quality and welfare. Ho
Externí odkaz:
https://doaj.org/article/f2ff9157c2e846a6bf25eae799dfab90
Autor:
Charles Mattis, Natalie Bratcher, Monika Burns, Christopher Carosino, Christina de Zafra, R. Marcus Fancher, Katrin Georgi, Candace Graff, Renee R. Hukkanen, Colena Johnson, Yanbin Lao, Amber Lange, Donna Lee, Michelle Lepherd, Sean Maguire, Mantas Malisauskas, Melinda Manuel, Sonia Miranda, Lori Reed, Rosemary Santos, Brian Sayers, David Shaw, David Shuster
Publikováno v:
International Journal of Toxicology. 41:291-296
The IQ Consortium NHP Reuse Working Group (WG) comprises members from 15 pharmaceutical and biotechnology companies. In 2020, the WG developed and distributed a detailed questionnaire on protein non-naïve NHP reuse to the WG member companies. The WG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b10e5fddd417acb06af1f508d5bc829
https://doi.org/10.1177/10915818221101791
https://doi.org/10.1177/10915818221101791
Autor:
Torben R. Neelands, Andrew O. Stewart, Gricelda H. Simler, Chengmin Zhong, Andrew J. King, Chang Z. Zhu, George Doherty, Andrew M. Swensen, Ivan Milicic, Janel M. Boyce-Rustay, Cenchen Zhan, Patricia N. Banfor, Timothy A. Vortherms, Victoria E. Scott, Natalie Bratcher, Michael F. Jarvis, Wende Niforatos, Helmut Mack, Pramila Bhatia
Publikováno v:
Biochemical Pharmacology. 83:406-418
Blockade of voltage-gated Ca²⁺ channels on sensory nerves attenuates neurotransmitter release and membrane hyperexcitability associated with chronic pain states. Identification of small molecule Ca²⁺ channel blockers that produce significant an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0e7b78ced7c8136433729efa16945e
https://doi.org/10.1016/j.bcp.2011.10.019
https://doi.org/10.1016/j.bcp.2011.10.019