Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Natalie Brajanovski"'
Autor:
Jian Kang, Natalie Brajanovski, Keefe T. Chan, Jiachen Xuan, Richard B. Pearson, Elaine Sanij
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-22 (2021)
Abstract Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Externí odkaz:
https://doaj.org/article/977bdd4f781a4596b021f41e01e07138
Autor:
Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and ove
Externí odkaz:
https://doaj.org/article/e147f3013f3440d1be5ac0b31368773d
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
All Supplementary Methods and associated references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019c8dd00fb9804dbcab5c9c85324ed7
https://doi.org/10.1158/2159-8290.22537003
https://doi.org/10.1158/2159-8290.22537003
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and its dysregulation is a common feature in cancer. We evaluated CX-5461, the first-in-class selective rDNA transcription inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918b37c279b207d3fe24ae1fef2b4322
https://doi.org/10.1158/2159-8290.c.6548299.v1
https://doi.org/10.1158/2159-8290.c.6548299.v1
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
Exposure-response relationship between CX-5461 levels and rDNA transcription rate in normal PBMCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cceb0aafa9c3ab75e00b6fe72c5a29
https://doi.org/10.1158/2159-8290.22537006.v1
https://doi.org/10.1158/2159-8290.22537006.v1
Autor:
Simon J. Harrison, Gretchen Poortinga, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Karen E. Sheppard, Andrew Fellowes, Ella R. Thompson, Piers Blombery, Emma Link, John Soong, John Lim, Elaine Sanij, Kylee H. Maclachlan, Nadine Hein, Donald P. Cameron, Natalie Brajanovski, Amit Khot
All Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee167dcf7bf74ae65a5fd3cc711e6d9e
https://doi.org/10.1158/2159-8290.22537000
https://doi.org/10.1158/2159-8290.22537000
Autor:
Jiachen Xuan, Richard B. Pearson, Ross D. Hannan, Shunfei Yan, Piyush B. Madhamshettiwar, Jian Kang, Karen E. Sheppard, Elaine Sanij, Keefe T. Chan, Kaylene J. Simpson, Carleen Cullinane, Sarah Ellis, Madeleine R. C. Tancock, Katherine M. Hannan, Natalie Brajanovski
Publikováno v:
British Journal of Cancer
Background Intrinsic and acquired drug resistance represent fundamental barriers to the cure of high-grade serous ovarian carcinoma (HGSC), the most common histological subtype accounting for the majority of ovarian cancer deaths. Defects in homologo
Autor:
Carleen Cullinane, Olga Kondrashova, Grant A. McArthur, Els M.J.J. Berns, Ross D. Hannan, Katherine M. Hannan, Jessica E. Ahern, Jian Kang, Elaine Sanij, Jinbae Son, Elizabeth Lieschke, John Soong, Keefe T. Chan, Natalie Brajanovski, Anna S Trigos, Karen E. Sheppard, Clare L. Scott, Matthew Wakefield, Linda Mileshkin, Jiachen Xuan, Purba Nag, Richard B. Pearson, Kum Kum Khanna, Andrew J. Deans, Daniel Frank, Shunfei Yan, Gretchen Poortinga, Sarah Ellis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 11(1). Nature Publishing Group
Nature Communications
Nature Communications, 11(1). Nature Publishing Group
Nature Communications
Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX-5461, the first-in-class inhibitor of RNA polymerase I transcription of ribosomal RNA
Autor:
Jiachen Xuan, Elaine Sanij, Richard B. Pearson, Jian Kang, Keefe T. Chan, Natalie Brajanovski
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-22 (2021)
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-22 (2021)
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function. In addit
Autor:
Ygal Haupt, Prerana Ghosh, Carleen Cullinane, Natalie Brajanovski, Gretchen Poortinga, Ian P. Street, Emily J. Lelliott, Laura Kirby, Keefe T. Chan, Mark G. Devlin, Richard B. Pearson, Elaine Sanij, Shatha AbuHammad, Lorey K. Smith, Michael A. Davies, Anthony T. Papenfuss, Alison Slater, Kerry Ardley, Sue Haupt, Karen E. Sheppard, Peter Lau, David J. Curtis, Hendrik Falk, Stupple Paul Anthony, Huiqin Chen, Grant A. McArthur, Margarete Kleinschmidt, Zoe Bacolas, Teresa Ward, Claire Martin, Aparna D. Rao, Ismael A. Vergara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Targeting CDK4/6 shows great promise in the treatment of many solid cancers, including melanoma. This study has uncovered a mechanism of action of CDK4/6 inhibitors in regulating the MDM4 oncogene and the tumor suppressor, p53. In melano