Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Natalie Barretto"'
Autor:
Seok-Man Ho, Brigham J. Hartley, Erin Flaherty, Prashanth Rajarajan, Rawan Abdelaal, Ifeanyi Obiorah, Natalie Barretto, Hamza Muhammad, Hemali P. Phatnani, Schahram Akbarian, Kristen J. Brennand
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 615-628 (2017)
Summary: Modulation of transcription, either synthetic activation or repression, via dCas9-fusion proteins is a relatively new methodology with the potential to facilitate high-throughput up- or downregulation studies of gene function. Genetic studie
Externí odkaz:
https://doaj.org/article/2772a37d93fb404291498f59170646ce
Autor:
James A. Gregory, Emily Hoelzli, Rawan Abdelaal, Catherine Braine, Miguel Cuevas, Madeline Halpern, Natalie Barretto, Nadine Schrode, Güney Akbalik, Kristy Kang, Esther Cheng, Kathryn Bowles, Steven Lotz, Susan Goderie, Celeste M. Karch, Sally Temple, Alison Goate, Kristen J. Brennand, Hemali Phatnani
Publikováno v:
Cells, Vol 9, Iss 6, p 1406 (2020)
Genetic and genomic studies of brain disease increasingly demonstrate disease-associated interactions between the cell types of the brain. Increasingly complex and more physiologically relevant human-induced pluripotent stem cell (hiPSC)-based models
Externí odkaz:
https://doaj.org/article/051c6b7b3fc94f27b8244d1722c52ff2
Autor:
Esther Cheng, Erin Flaherty, Gabriel E. Hoffman, Marliette R. Matos, Amanda Dobbyn, Vineeta Singh, Deeptha Girish, Eli A. Stahl, Hirofumi Morishita, Laura M. Huckins, Seok-Man Ho, Emily Hoelzli, Sonya Abadali, Robert E. McCullumsmith, Pamela Sklar, Kazuhiko Yamamuro, Aaron Topol, Hemali Phatnani, Khaled Alganem, P J Michael Deans, Nadine Schrode, Bruce J. Aronow, James Gardner Gregory, Natalie Barretto, Kristen J. Brennand
Publikováno v:
Nature genetics
The mechanisms by which common risk variants of small effect interact to contribute to complex genetic disorders remain unclear. Here, we apply a genetic approach, using isogenic human induced pluripotent stem cells (hiPSCs), to evaluate the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ed3bce958e513e0c868faa3ba3030b
http://europepmc.org/articles/PMC6778520
http://europepmc.org/articles/PMC6778520
Autor:
Samuel K. Powell, Erin Flaherty, Michael B. Fernando, Jubao Duan, Hanwen Zhang, Paul A. Slesinger, Seok-Man Ho, Siwei Zhang, Natalie Barretto, Kristen J. Brennand
Publikováno v:
J Neurosci Methods
Background Somatic cell reprogramming is routinely used to generate donor-specific human induced pluripotent stem cells (hiPSCs) to facilitate studies of disease in a human context. The directed differentiation of hiPSCs can generate large quantities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bff2cd1ddf9ca4d4aaa11256c289cb2
https://pubmed.ncbi.nlm.nih.gov/32065989
https://pubmed.ncbi.nlm.nih.gov/32065989
Autor:
Michael B. Fernando, Natalie Barretto, Kristen J. Brennand, Nadine Schrode, Esther Cheng, Robert Sebra, Gintaras Deikus, Megan L. Fitzgerald, Robert E. McCullumsmith, Erin Flaherty, P J Michael Deans, Peter Gochman, Nancy Francoeur, Judith L. Rapoport, Hardik Shah, Ian Ladran, Alesia Antoine, Nadejda M. Tsankova, Shijia Zhu, Gabriel E. Hoffman, Madeline Halpern, Khaled Alganem, Gang Fang
Publikováno v:
Nature genetics
NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human induced pluripotent stem cell (hiPSC)-derived neurons represent well th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3153c7be8dda7f8bace71c6942e6be
https://pubmed.ncbi.nlm.nih.gov/31784728
https://pubmed.ncbi.nlm.nih.gov/31784728
Autor:
Emily Hoelzli, James A Gregory, Steven Lotz, Hemali Phatnani, Rawan Abdelaal, Susan K. Goderie, Güney Akbalik, Esther Cheng, Kristy Kang, Miguel Cuevas, Madeline Halpern, Celeste M. Karch, Natalie Barretto, Kathryn R. Bowles, Kristen J. Brennand, Nadine Schrode, Alison Goate, Catherine E. Braine, Sally Temple
Publikováno v:
Cells
Volume 9
Issue 6
Cells, Vol 9, Iss 1406, p 1406 (2020)
Volume 9
Issue 6
Cells, Vol 9, Iss 1406, p 1406 (2020)
Genetic and genomic studies of brain disease increasingly demonstrate disease-associated interactions between the cell types of the brain. Increasingly complex and more physiologically relevant human induced pluripotent stem cell (hiPSC)-based models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f3eaf4846a9dcb6d386ad73c035214
https://doi.org/10.3390/cells9061406
https://doi.org/10.3390/cells9061406