Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Natalie B Vinh"'
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 11 (2022)
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required
Externí odkaz:
https://doaj.org/article/0679868db9304f46bdc0d01432a2d431
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64837c0876829a0b9019d72507ac5aa8
https://doi.org/10.7554/elife.80813.sa2
https://doi.org/10.7554/elife.80813.sa2
Autor:
Petar P.S. Calic, Natalie B. Vinh, Chaille T. Webb, Tess R. Malcolm, Anna Ngo, Kym Lowes, Nyssa Drinkwater, Sheena McGowan, Peter J. Scammells
Publikováno v:
European Journal of Medicinal Chemistry. 248:115051
Autor:
Luke S. Schembri, Susan A. Charman, Sheena McGowan, Georgina S. Butler, Christopher M. Overall, Jisook Lee, Wei Yang, Nyssa Drinkwater, Peter M. Grin, Peter J. Scammells, Natalie B. Vinh, Komagal Kannan Sivaraman, Michelle Gazdik
Publikováno v:
Journal of Medicinal Chemistry
Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inh
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases
Autor:
Sandra Duffy, Peter J. Scammells, Peter M. Grin, Tess R. Malcolm, Georgina S. Butler, Vicky M. Avery, Leonardo Lucantoni, Christopher M. Overall, Sheena McGowan, Natalie B. Vinh, Nyssa Drinkwater, Michael Kassiou
Publikováno v:
Journal of medicinal chemistry. 62(2)
There is an urgent clinical need for antimalarial compounds that target malaria caused by both Plasmodium falciparum and Plasmodium vivax. The M1 and M17 metalloexopeptidases play key roles in Plasmodium hemoglobin digestion and are validated drug ta
Autor:
Natalie B. Vinh, Peter J. Scammells, Khadija Mohamed, Sheena McGowan, Nyssa Drinkwater, Wioletta Rut, Komagal Kannan Sivaraman, Rebecca S. Bamert, Marcin Drag
Publikováno v:
Biochemical Journal. 473:3189-3204
Malaria is one of the world's most prevalent parasitic diseases, with over 200 million cases annually. Alarmingly, the spread of drug-resistant parasites threatens the effectiveness of current antimalarials and has made the development of novel thera
Autor:
Henry Krum, David K. Chalmers, Renae M. Ryan, Jamie S. Simpson, Peter J. Scammells, Shane M. Devine, Bing Hui Wang, Natalie B. Vinh, Lenka Munoz
Publikováno v:
ChemistryOpen
p38α mitogen-activated protein kinase (MAPK) plays a role in several cellular processes and consequently has been a therapeutic target in inflammatory diseases, cancer, and cardiovascular disease. A number of known p38α MAPK inhibitors contain vici
Autor:
Chiara Ruggeri, Sasdekumar Loganathan, Vicky M. Avery, Peter J. Scammells, Nyssa Drinkwater, Rebecca S. Bamert, Andrew K. Powell, Susan A. Charman, Sheena McGowan, John P. Holleran, Natalie B. Vinh, Alessandro Paiardini, Shailesh N. Mistry
© 2016 Elsevier Masson SAS. Malaria remains a global health problem, and though international efforts for treatment and eradication have made some headway, the emergence of drug-resistant parasites threatens this progress. Antimalarial therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2d8ab24108b25b357b0e48440ae6c0
https://nottingham-repository.worktribe.com/file/772793/1/1-s2.0-S0223523416300150-main.pdf
https://nottingham-repository.worktribe.com/file/772793/1/1-s2.0-S0223523416300150-main.pdf
Publikováno v:
Journal of Computer-Aided Molecular Design. 26:409-423
We have used virtual screening to develop models for the binding of aryl substituted heterocycles to p38α MAPK. Virtual screening was conducted on a number of p38α MAPK crystal structures using a library of 46 known p38α MAPK inhibitors containing
Autor:
Manuela Jörg, J. Robert Lane, Ben Capuano, Natalie B. Vinh, Peter J. Scammells, Patrick M. Sexton, Shailesh N. Mistry, Arthur Christopoulos, Herman Lim
Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (M1 mAChR) are a promising strategy for the treatment of the cognitive deficits associated with diseases including Alzheimer's and schizophrenia. Herein, we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd87bd1b83815381ee0cf1ec3844303
http://eprints.nottingham.ac.uk/31240/
http://eprints.nottingham.ac.uk/31240/