Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Natalie B Collins"'
Autor:
Yashaswi Shrestha, Michael Quigley, Travis Hughes, Robert T Manguso, Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Marc Wadsworth, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Oncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood.Methods We use an in vivo expression screen of known c
Externí odkaz:
https://doaj.org/article/2f18639e65804873a00ab93aef07c6bc
Autor:
Suzanne J. Forrest, Hersh Gupta, Abigail Ward, Yvonne Y. Li, Duong Doan, Alyaa Al-Ibraheemi, Sanda Alexandrescu, Pratiti Bandopadhayay, Suzanne Shusterman, Elizabeth A. Mullen, Natalie B. Collins, Susan N. Chi, Karen D. Wright, Priti Kumari, Tali Mazor, Keith L. Ligon, Priyanka Shivdasani, Monica Manam, Laura E. MacConaill, Evelina Ceca, Sidney N. Benich, Wendy B. London, Richard L. Schilsky, Suanna S. Bruinooge, Jaime M. Guidry Auvil, Ethan Cerami, Barrett J. Rollins, Matthew L. Meyerson, Neal I. Lindeman, Bruce E. Johnson, Andrew D. Cherniack, Alanna J. Church, Katherine A. Janeway
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract To inform clinical trial design and real-world precision pediatric oncology practice, we classified diagnoses, assessed the landscape of mutations, and identified genomic variants matching trials in a large unselected institutional cohort of
Externí odkaz:
https://doaj.org/article/4017a15f72474d229f7c23ceb2ec8422
Autor:
Suzanne J. Forrest, Hersh Gupta, Abigail Ward, Yvonne Y. Li, Duong Doan, Alyaa Al-Ibraheemi, Sanda Alexandrescu, Pratiti Bandopadhayay, Suzanne Shusterman, Elizabeth A. Mullen, Natalie B. Collins, Susan N. Chi, Karen D. Wright, Priti Kumari, Tali Mazor, Keith L. Ligon, Priyanka Shivdasani, Monica Manam, Laura E. MacConaill, Evelina Ceca, Sidney N. Benich, Wendy B. London, Richard L. Schilsky, Suanna S. Bruinooge, Jaime M. Guidry Auvil, Ethan Cerami, Barrett J. Rollins, Matthew L. Meyerson, Neal I. Lindeman, Bruce E. Johnson, Andrew D. Cherniack, Alanna J. Church, Katherine A. Janeway
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/fb4f1740ba5f49008685d912d84b0bbb
Autor:
Ajami Gikandi, Susan N. Chi, Kee Kiat Yeo, Allison F. O'Neill, David S. Shulman, Steven G. DuBois, Natalie B. Collins
Publikováno v:
Cancer Medicine, Vol 13, Iss 8, Pp n/a-n/a (2024)
Abstract Background Immune checkpoint inhibitors (ICI) have improved outcomes in a variety of adult cancers and are prescribed with increasing frequency across oncology. However, patterns of off‐label use of ICI in pediatrics remain unclear. Method
Externí odkaz:
https://doaj.org/article/c0b09fda39d84998acabc99d862c2cad
Autor:
Dylan V. Neel, Clement Ma, Natalie B. Collins, Jason L. Hornick, George D. Demetri, David S. Shulman
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 170-178 (2023)
Abstract Background Synovial sarcoma (SS) accounts for 8%–10% of all soft‐tissue sarcomas. Clinical presentation and outcomes vary, yet discrete risk groups based on validated prognostic indices are not defined for the full spectrum of patients w
Externí odkaz:
https://doaj.org/article/da807d720bf34f49befe2d047ca5dbb0
Autor:
Anirban Das, Uri Tabori, Lauren C. Sambira Nahum, Natalie B. Collins, Rebecca Deyell, Rina Dvir, Cecile Faure-Conter, Timothy E. Hassall, Jane E. Minturn, Melissa Edwards, Elissa Brookes, Vanessa Bianchi, Adrian Levine, Simone C. Stone, Sumedha Sudhaman, Santiago Sanchez-Ramirez, Ayse B. Ercan, Lucie Stengs, Jiil Chung, Logine Negm, Gad Getz, Yosef E. Maruvka, Birgit Ertl-Wagner, Pamela S. Ohashi, Trevor Pugh, Cynthia Hawkins, Eric Bouffet, Daniel A. Morgenstern
Publikováno v:
Clinical Cancer Research.
Purpose: Checkpoint-inhibitors have limited efficacy for children with unselected solid and brain tumors. We report the first prospective pediatric trial (NCT02992964) using nivolumab exclusively for refractory non-hematological cancers harboring tum
Autor:
Dylan V. Neel, Clement Ma, Natalie B. Collins, Jason L. Hornick, George D. Demetri, David S. Shulman
Publikováno v:
Cancer Medicine. 12:170-178
Synovial sarcoma (SS) accounts for 8%-10% of all soft-tissue sarcomas. Clinical presentation and outcomes vary, yet discrete risk groups based on validated prognostic indices are not defined for the full spectrum of patients with SS.We performed a re
Autor:
Junne Kamihara, Natalie B. Collins
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
Autor:
Lorena Lazo De La Vega, Hannah Comeau, Sarah Sallan, Alyaa Al-Ibraheemi, Hersh Gupta, Yvonne Y. Li, Harrison K. Tsai, Wenjun Kang, Abigail Ward, Alanna J. Church, AeRang Kim, Navin R. Pinto, Margaret E. Macy, Luke D. Maese, Amit J. Sabnis, Andrew D. Cherniack, Neal I. Lindeman, Megan E. Anderson, Tabitha M. Cooney, Kee Kiat Yeo, Gregory H. Reaman, Steven G. DuBois, Natalie B. Collins, Bruce E. Johnson, Katherine A. Janeway, Suzanne J. Forrest
Publikováno v:
JCO precision oncology. 6
PURPOSE Multiple FGFR inhibitors are currently in clinical trials enrolling adults with different solid tumors, while very few enroll pediatric patients. We determined the types and frequency of FGFR alterations ( FGFR1-4) in pediatric cancers to inf
Autor:
Yanay Rosen, Timothy L. Tickle, Joshua Gould, Satyen H. Gohil, Danielle Dionne, Natalie B. Collins, Gabriela Smith-Rosario, Orr Ashenberg, Michal Slyper, Johanna Klughammer, Avinash Waghray, Julia Waldman, F. Stephen Hodi, Anand G. Patel, Catherine J. Wu, Sébastien Vigneau, Simon Gritsch, Masashi Nomura, Eugene Drokhlyansky, Suzanne J. Baker, Sara Napolitano, Isaac Wakiro, Mario L. Suvà, Caroline B. M. Porter, Aviv Regev, Nikhil Wagle, Jingyi Wu, Ursula A. Matulonis, Elizabeth H. Stover, Michael A. Dyer, Orit Rozenblatt-Rosen, Charles H. Yoon, Aaron N. Hata, Asa Karlstrom, Bruce E. Johnson, Rizwan Haq, Bo Li, Christopher Smillie, Matan Hofree, Michael R. Clay, Lan Nguyen, Raphael Bueno, Judit Jané-Valbuena, Alexander M. Tsankov, Benjamin Izar, Peter J. Tramontozzi, Ofir Cohen, Livnat Jerby-Arnon, Mei-Ju Su, Asaf Rotem
Publikováno v:
Nature Medicine
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors.