Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Natalie A. Mellett"'
Autor:
Tingting Wang, Habtamu B. Beyene, Changyu Yi, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Jingqin Wu, Aleksandar Dakic, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero, Rima Kaddurah-Daouk, Agus Salim, Eric K. Moses, Jonathan E. Shaw, Dianna J. Magliano, Kevin Huynh, Corey Giles, Peter J. Meikle
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105199- (2024)
Summary: Background: Metabolic ageing biomarkers may capture the age-related shifts in metabolism, offering a precise representation of an individual’s overall metabolic health. Methods: Utilising comprehensive lipidomic datasets from two large ind
Externí odkaz:
https://doaj.org/article/6698e57fd19a45a9bcec8960081f22cf
Autor:
Habtamu B. Beyene, Kevin Huynh, Tingting Wang, Sudip Paul, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero, Eric K. Moses, Jonathan E. Shaw, Dianna J. Magliano, Corey Giles, Peter J. Meikle
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105187- (2024)
Summary: Background: Decreased levels of circulating ethanolamine plasmalogens [PE(P)], and a concurrent increase in phosphatidylethanolamine (PE) are consistently reported in various cardiometabolic conditions. Here we devised, a plasmalogen score (
Externí odkaz:
https://doaj.org/article/6460998e7f29410798ff72ed8d73606f
Autor:
Habtamu B. Beyene, Corey Giles, Kevin Huynh, Tingting Wang, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Gerald F. Watts, Joseph Hung, Jennie Hui, Gemma Cadby, John Beilby, John Blangero, Eric K. Moses, Jonathan E. Shaw, Dianna J. Magliano, Peter J. Meikle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with me
Externí odkaz:
https://doaj.org/article/c40a6d45d04746158313a34018147a53
Autor:
M. John Chapman, Alexina Orsoni, Natalie A. Mellett, Anh Nguyen, Paul Robillard, Jonathan E. Shaw, Philippe Giral, Patrice Thérond, Debi Swertfeger, W. Sean Davidson, Peter J. Meikle
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100494- (2024)
HDL particles vary in lipidome and proteome, which dictate their individual physicochemical properties, metabolism, and biological activities. HDL dysmetabolism in nondiabetic hypertriglyceridemia (HTG) involves subnormal HDL-cholesterol and apoAI le
Externí odkaz:
https://doaj.org/article/4d46b381a68a4fab940cc188dc18336c
Autor:
Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S. McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dubé, Gerald F. Watts, Sonia Shah, Naomi R. Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Tenielle Porter, Michael Vacher, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J. Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, John Blangero, Peter J. Meikle, Eric K. Moses
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Dysregulation of lipid metabolism is associated with coronary artery disease (CAD). Here, the authors perform GWAS of the serum lipidome to identify variants associated with lipid species that are putatively in the mechanistic pathway to CAD.
Externí odkaz:
https://doaj.org/article/1160229aa3d04cc8a6b15b682b0f47a7
Autor:
Jerry D. Monroe, Daniel Fraher, Xiaoqian Huang, Natalie A. Mellett, Peter J. Meikle, Andrew J. Sinclair, Seth T. Lirette, Nita J. Maihle, Zhiyuan Gong, Yann Gibert
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is accompanied by complex dysregulation of lipids. Increasing evidence suggests that particular lipid species are associated with HCC progression. Here, we
Externí odkaz:
https://doaj.org/article/ca7c4c03f46740fa8554fdb16d1f48af
Autor:
Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett, Andrew J. Hoy, Pan Du, Jianjun Yu, Shidong Jia, Anthony M. Joshua, David J. Waugh, Lisa M. Butler, Manish Kohli, Peter J. Meikle, Arun A. Azad, Lisa G. Horvath
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with metastatic castratio
Externí odkaz:
https://doaj.org/article/0c49ff062a1c4a14adec64ab46d60c0a
Autor:
Cesare Granata, Nikeisha J. Caruana, Javier Botella, Nicholas A. Jamnick, Kevin Huynh, Jujiao Kuang, Hans A. Janssen, Boris Reljic, Natalie A. Mellett, Adrienne Laskowski, Tegan L. Stait, Ann E. Frazier, Melinda T. Coughlan, Peter J. Meikle, David R. Thorburn, David A. Stroud, David J. Bishop
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Exercise training can be therapeutic but how mitochondria respond remains unclear. Here, the authors use multiple omics techniques to reveal a complex network of non-stoichiometric mitochondrial adaptations that are prioritized or deprioritised durin
Externí odkaz:
https://doaj.org/article/bea2037780444510914f0ea9d4120a6f
Autor:
Simon T. Bond, Emily J. King, Darren C. Henstridge, Adrian Tran, Sarah C. Moody, Christine Yang, Yingying Liu, Natalie A. Mellett, Artika P. Nath, Michael Inouye, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The genetic determinants of sex-specific differences in obesity are still incompletely understood. Here, the authors demonstrate that adipocyte specific loss of Trim28 in committed adipocytes leads to sex specific differences in the development of ob
Externí odkaz:
https://doaj.org/article/153ba01f3e9e4f4784fc02d6c030c7c9
Autor:
Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S. Jayawardana, Agus Salim, Natalie A. Mellett, Adam Alexander T. Smith, Gavriel Olshansky, Brian G. Drew, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Matthias Arnold, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, Peter J. Meikle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the p
Externí odkaz:
https://doaj.org/article/4dd529924c75463b9ab9f71c074acad6