Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Natalie A. Bilci"'
Autor:
Nicholas Marcopulos, Gary M. Coppola, Beatriz Dardik, Paivi J. Kukkola, Jenny Tan, Hua Wang, Ricardo E. Chatelain, James L. Stanton, Alan D. Neubert, Natalie A. Bilci, Thomas D. Aicher, Arco Y. Jeng, Hollis C. Tomaselli, Douglas C. Knorr
Publikováno v:
Journal of Medicinal Chemistry. 48:6696-6712
High-throughput screening identified 5 as a weak inhibitor of 11beta-HSD1. Optimization of the structure led to a series of perhydroquinolylbenzamides, some with low nanomolar inhibitory potency. A tertiary benzamide is required for biological activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abb3ffe30f7a8d7d4ca7e3980f503c2
https://doi.org/10.1021/jm058228q
https://doi.org/10.1021/jm058228q
Autor:
Paivi Jaana Kukkola, Suraj S. Shetty, Natalie A. Bilci, Paula Savage, Theodore Ikler, Arco Y. Jeng, Dominick DelGrande
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1737-1740
1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6e1f77d9a18d7b3a45f6a318e01761
https://doi.org/10.1016/s0960-894x(01)00273-6
https://doi.org/10.1016/s0960-894x(01)00273-6
Publikováno v:
Tetrahedron Letters. 37:5065-5068
The described synthesis of isomeric isoindoline dicarboxylic acid analogs 1 and 2, two potent ETA selective receptor antagonists, involves an efficient regioselective route to highly functionalized dibenzoylbenzenes and a novel methodology for the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b68ee7bcb04b05b8040e3d99eab9837
https://doi.org/10.1016/0040-4039(96)01018-0
https://doi.org/10.1016/0040-4039(96)01018-0
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:619-624
The structural requirements of retro-thiorphan, N -[1 R , S -benzyl-2-mercaptoethyl]malonamic acid 2 , analogs for the inhibition of endothelin converting enzyme (ECE) were investigated. Although based on a single amino acid residue, N -[1 R -(1 H -i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::192d2b41984e1f6d7218fbdb6cff3eae
https://doi.org/10.1016/0960-894x(96)00091-1
https://doi.org/10.1016/0960-894x(96)00091-1
Publikováno v:
ChemInform. 27
The described synthesis of isomeric isoindoline dicarboxylic acid analogs 1 and 2, two potent ETA selective receptor antagonists, involves an efficient regioselective route to highly functionalized dibenzoylbenzenes and a novel methodology for the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a9f804ece20eb75aff2a9f9bb6e9f6
https://doi.org/10.1002/chin.199643086
https://doi.org/10.1002/chin.199643086
Autor:
Arco Y. Jeng, Dominick DelGrande, Natalie A. Bilci, Paula Savage, Paivi Jaana Kukkola, Suraj S. Shetty, Theodore Ikler
Publikováno v:
ChemInform. 32
1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c242b0772da276445eea28df4233ef0d
https://doi.org/10.1002/chin.200147099
https://doi.org/10.1002/chin.200147099
Autor:
David Louis Feldman, Randy L. Webb, Warren Lee, Ashok Hospattankar, Michael Jeune, Alan D. Neubert, Natalie A. Bilci, Natalya Alexander, Andrew M. Yuan, Therese C Mogelesky, Aida E. Navarrete, Gary Michael Ksander, Joyce C. Gibson, Eric Carlson, Haamid M. Sharif, Eli M. Wallace, Jong Wasvery, Reynalda Dejesus, Paivi Jaana Kukkola, Edna Cahill, Michael A. Moskal, Cynthia A. Fink, Steele Ronald Edward, Zouhair F. Stephan, Kevin Poirier
Publikováno v:
Journal of medicinal chemistry. 44(26)
The synthesis and biological activities of biarylamide-substituted diaminoindanes as microsomal triglyceride transfer protein (MTP) inhibitors are described. One of the more potent compounds, 8aR, inhibited both the secretion of apoB from Hep G2 cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0586d5545b1198cefd0a15bfddbac44
https://pubmed.ncbi.nlm.nih.gov/11741485
https://pubmed.ncbi.nlm.nih.gov/11741485