Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Natalie A. Bécar"'
Autor:
Joshua L. Price, Natalie A. Bécar, Andrew R. Stephens, Paul B. Lawrence, Derek J. Matheson, Steven R. E. Draper, Wendy M. Billings, Qiang Xiao, Nathaniel P. Brown
Publikováno v:
Bioconjugate Chemistry. 28:2507-2513
The development of chemical strategies for site-specific protein modification now enables researchers to attach polyethylene glycol (PEG) to a protein drug at one or more specific locations (i.e., protein PEGylation). However, aside from avoiding enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fb726d00cc45f33f8bbcbd7b3d5f84b
https://doi.org/10.1021/acs.bioconjchem.7b00281
https://doi.org/10.1021/acs.bioconjchem.7b00281
Autor:
Kimberlee S. Larsen, Natalie A. Bécar, Joshua L. Price, Eliza E. K. Lawrence, M.S. Smith, Wendy M. Billings
Publikováno v:
ACS Chemical Biology. 12:2535-2537
Anions have long been known to engage in stabilizing interactions with electron-deficient arenes. However, the precise nature and energetic contribution of anion-π interactions to protein stability remains a subject of debate. Here, we show that pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dc2f3393fb737f3db723318a8b6189
https://doi.org/10.1021/acschembio.7b00768
https://doi.org/10.1021/acschembio.7b00768
Autor:
Katherine P. Thompson, Natalie A. Bécar, M.S. Smith, Joshua L. Price, Nathaniel P. Brown, Steven R. E. Draper, Qiang Xiao, K.L. Stern
Publikováno v:
Organicbiomolecular chemistry. 16(46)
Hydrocarbon stapling and PEGylation are distinct strategies for enhancing the conformational stability and/or pharmacokinetic properties of peptide and protein drugs. Here we combine these approaches by incorporating asparagine-linked O-allyl PEG oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0947c2b7941696adb62b66a5d70a963
https://pubmed.ncbi.nlm.nih.gov/30444518
https://pubmed.ncbi.nlm.nih.gov/30444518