Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Natalie A, Dales"'
Autor:
Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon
Publikováno v:
Cell Chemical Biology. 30:235-247.e12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa86b497ea26c675d8f51551ced46e99
https://doi.org/10.1016/j.chembiol.2023.02.005
https://doi.org/10.1016/j.chembiol.2023.02.005
Autor:
Jake, Axford, Moo Je, Sung, John, Manchester, Donovan, Chin, Monish, Jain, Youngah, Shin, Ina, Dix, Lawrence G, Hamann, Atwood K, Cheung, Rajeev, Sivasankaran, Karin, Briner, Natalie A, Dales, Brian, Hurley
Publikováno v:
Journal of medicinal chemistry. 64(8)
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13330dc0c7e19f69d4bd3cf1bf193353
https://pubmed.ncbi.nlm.nih.gov/33822618
https://pubmed.ncbi.nlm.nih.gov/33822618
Publikováno v:
CHIMIA, Vol 51, Iss 1-2 (1997)
With the intent of discovering novel molecular scaffolds for designing protease inhibitors, the computer program GrowMol was used to generate peptidemimetic inhibitors of aspartic proteases. Beginning with the X-ray crystal structure of A66702 comple
Externí odkaz:
https://doaj.org/article/78683646fd3947d791a37659bd40fd37
Autor:
Dominic Ryan, David Williams, Paul Towler, Jin Tang, Natalie A. Dales, Martin Fisher, Sridhar Prasad, Thomas F. Parsons, Saurabh Menon, Michael W. Pantoliano, Michael A. Patane, Bart L. Staker
Publikováno v:
The Journal of Biological Chemistry
The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE2, is a type I integral membrane protein of 805 amino acids that contains one HEXXH + E zinc-binding consensus sequence. ACE2 has been implicated in the regulation of heart function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba95732e63f969868aa8d11d43b7946d
https://doi.org/10.1074/jbc.m311191200
https://doi.org/10.1074/jbc.m311191200
Publikováno v:
Synthetic Communications. 28:4463-4470
(3R)-amino-(2S)-hydroxy heptanoic acid (AHHpA) was synthesized via asymmetric aminohydroxylation and coupled with di-and tripeptides to form three compounds that inhibit MetAP-1 with IC50 values in the low micromolar range.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda713310c9e03ee92eabcb8cd63ce44
https://doi.org/10.1080/00397919808004481
https://doi.org/10.1080/00397919808004481
Publikováno v:
Journal of medicinal chemistry. 57(12)
This review provides an overview of stearoyl-coenzyme A desaturase-1 (SCD1) as a novel therapeutic target for metabolic disorders and other indications. Target validation is reviewed, and limitations due to incomplete knowledge of the relevant biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::884db65e76cf6fde8b38651a05dcdfd2
https://pubmed.ncbi.nlm.nih.gov/24295027
https://pubmed.ncbi.nlm.nih.gov/24295027
Publikováno v:
ChemInform. 30
(3R)-amino-(2S)-hydroxy heptanoic acid (AHHpA) was synthesized via asymmetric aminohydroxylation and coupled with di-and tripeptides to form three compounds that inhibit MetAP-1 with IC50 values in the low micromolar range.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b48ee7193fde546441c9d4ce55cdcd
https://doi.org/10.1002/chin.199907218
https://doi.org/10.1002/chin.199907218
Publikováno v:
ChemInform. 32
The design, synthesis, and enzyme inhibition of a new class of aspartic peptidase inhibitors is described. Unsymmetrical ureas were designed from computer-generated structures. Using mechanism-based and substrate-based design techniques, potent pepsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0632a8bdbf25ede2dfb2975cff4b5bb1
https://doi.org/10.1002/chin.200149166
https://doi.org/10.1002/chin.200149166
Publikováno v:
Organic letters. 3(15)
[structure: see text] The design, synthesis, and enzyme inhibition of a new class of aspartic peptidase inhibitors is described. Unsymmetrical ureas were designed from computer-generated structures. Using mechanism-based and substrate-based design te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f677a4ab8f6441d01faf606474260c4
https://pubmed.ncbi.nlm.nih.gov/11463304
https://pubmed.ncbi.nlm.nih.gov/11463304