Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Natalie A, Counihan"'
Autor:
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum an
Externí odkaz:
https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 781 (2024)
Parasite-derived new permeation pathways (NPPs) expressed at the red blood cell (RBC) membrane enable Plasmodium parasites to take up nutrients from the plasma to facilitate their survival. Thus, NPPs represent a potential novel therapeutic target fo
Externí odkaz:
https://doaj.org/article/c598ceda8aaa4ad2be72351fc0c4b057
Autor:
Ethan L. Pitman, Natalie A. Counihan, Joyanta K. Modak, Mrittika Chowdury, Paul R. Gilson, Chaille T. Webb, Tania F. de Koning-Ward
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Apicomplexan parasites that reside within a parasitophorous vacuole harbor a conserved pore-forming protein that enables small-molecule transfer across the parasitophorous vacuole membrane (PVM). In Plasmodium parasites that cause malaria, this nutri
Externí odkaz:
https://doaj.org/article/2c2296a400ba4f69a1d25067b58f9743
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 11 (2022)
Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required
Externí odkaz:
https://doaj.org/article/0679868db9304f46bdc0d01432a2d431
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Plasmodium falciparum malaria remains a global health problem as parasites continue to develop resistance to all antimalarials in use. Infection causes clinical symptoms during the intra-erythrocytic stage of the lifecycle where the parasite infects
Externí odkaz:
https://doaj.org/article/5a28ffe928e54ec59999fb2cf6669561
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Plasmodium parasites responsible for the disease malaria reside within erythrocytes. Inside this niche host cell, parasites internalize and digest host hemoglobin to source amino acids required for protein production. However, hemoglobin does not con
Externí odkaz:
https://doaj.org/article/0ff9472bbfb343759614892b1f46e0ca
Autor:
Sreejoyee Ghosh, Scott A Chisholm, Madeline Dans, Asha Lakkavaram, Kit Kennedy, Stuart A Ralph, Natalie A Counihan, Tania F de Koning-Ward
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193538 (2018)
The ability of Plasmodium parasites to egress from their host red blood cell is critical for the amplification of these parasites in the blood. Previous forward chemical genetic approaches have implicated the subtilisin-like protease (SUB1) and the c
Externí odkaz:
https://doaj.org/article/fe4e9dc4fac34c4ea30a511940745b33
Autor:
Natalie A Counihan, Scott A Chisholm, Hayley E Bullen, Anubhav Srivastava, Paul R Sanders, Thorey K Jonsdottir, Greta E Weiss, Sreejoyee Ghosh, Brendan S Crabb, Darren J Creek, Paul R Gilson, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium falciparum parasites, the causative agents of malaria, modify their host erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and for removal of toxic waste. Here we investigate the contribution of the rhop
Externí odkaz:
https://doaj.org/article/97ed3bf0078b4d8eba8c42a7a6284862
Autor:
Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64837c0876829a0b9019d72507ac5aa8
https://doi.org/10.7554/elife.80813.sa2
https://doi.org/10.7554/elife.80813.sa2
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Plasmodium falciparum malaria remains a global health problem as parasites continue to develop resistance to all antimalarials in use. Infection causes clinical symptoms during the intra-erythrocytic stage of the lifecycle where the parasite infects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f90f91727a0a0427c2d6f44a016b832
https://pubmed.ncbi.nlm.nih.gov/35096663
https://pubmed.ncbi.nlm.nih.gov/35096663