Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Natalie, Mesens"'
Autor:
Natalie, Mesens, Margino, Steemans, Erik, Hansen, Annelieke, Peters, Geert, Verheyen, Philippe, Vanparys
Publikováno v:
In Toxicology in Vitro 2009 23(2):217-226
Autor:
Mikael Persson, Helga H.J. Gerets, Klaus Gjervig Jensen, Natalie Mesens, Jan Snoeys, B. Kevin Park, Tracy Walker, James L. Stevens, Catherine J. Betts, Gilles Labbe, Monday O. Ogese, Richard J. Weaver, Philip G. Hewitt, Michael J. Liguori, Eric A.G. Blomme, Satu Juhila
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 13:767-782
Introduction: The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59454364f73e9723c979fac2b6f4384
https://doi.org/10.1080/17425255.2017.1341489
https://doi.org/10.1080/17425255.2017.1341489
Autor:
Erik Hansen, Freddy Van Goethem, Natalie Mesens, Peter de Witte, Camila V. Esguerra, Jacky Van Gompel, Rik Nuyts, Alexander D. Crawford, Pham Duc Hung, Andre Wolterbeek, Aswin Menke
Publikováno v:
Journal of Applied Toxicology. 35:1017-1029
Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because of the lack of physiological interactions with other cells within the liver. An intact whole liver system such as one present in zebrafish larvae could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2dad8b5133a0708172f7e3f79ee8694
https://doi.org/10.1002/jat.3091
https://doi.org/10.1002/jat.3091
Autor:
Richard J, Weaver, Catherine, Betts, Eric A G, Blomme, Helga H J, Gerets, Klaus, Gjervig Jensen, Philip G, Hewitt, Satu, Juhila, Gilles, Labbe, Michael J, Liguori, Natalie, Mesens, Monday O, Ogese, Mikael, Persson, Jan, Snoeys, James L, Stevens, Tracy, Walker, B Kevin, Park
Publikováno v:
Expert opinion on drug metabolismtoxicology. 13(7)
The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue for drug deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a103b9bba96c164ef146861a2a771354
https://pubmed.ncbi.nlm.nih.gov/28604124
https://pubmed.ncbi.nlm.nih.gov/28604124
Publikováno v:
Drug Metabolism Reviews. 44:127-140
Drug-induced liver injury (DILI) is a major cause of attrition during both the early and later stages of the drug development and marketing process. Reducing or eliminating drug-induced severe liver injury, especially those that lead to liver transpl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3e99ee1b84380251d1e70d9cfed44c
https://doi.org/10.3109/03602532.2011.645578
https://doi.org/10.3109/03602532.2011.645578
Autor:
Erik Hansen, Geert R. Verheyen, Freddy Van Goethem, Jaques Van Gompel, Margino Steemans, Natalie Mesens
Publikováno v:
Toxicology in Vitro. 24:1417-1425
Drug-induced phospholipidosis is a side effect for which drug candidates can be screened in the drug discovery phase. The numerous in silico models that have been developed as a first line of screening are based on the characteristic physicochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b0a9774fb703277dd40cc489fd5a5a
https://doi.org/10.1016/j.tiv.2010.04.007
https://doi.org/10.1016/j.tiv.2010.04.007
Autor:
Annelieke K. Peters, Natalie Mesens, Geert R. Verheyen, Margino Steemans, Erik Hansen, Philippe Vanparys
Publikováno v:
Toxicological Sciences. 105:342-350
The ability of murine-derived embryonic stem cells (D3) to differentiate into cardiomyocytes is the basis of the embryonic stem cell test (EST). With the EST, chemicals and pharmaceuticals can be assessed for their embryotoxic potency early on in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6306861951231711ef9eed5792e702
https://doi.org/10.1093/toxsci/kfn126
https://doi.org/10.1093/toxsci/kfn126
Autor:
Natalie Mesens
Publikováno v:
Predictive Toxicology: From Vision to Reality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07965060b59dea79cadb750f0109253d
https://doi.org/10.1002/9783527674183.ch11
https://doi.org/10.1002/9783527674183.ch11
Autor:
Natalie, Mesens, Alexander D, Crawford, Aswin, Menke, Pham Duc, Hung, Freddy, Van Goethem, Rik, Nuyts, Erik, Hansen, Andre, Wolterbeek, Jacky, Van Gompel, Peter, De Witte, Camila V, Esguerra
Publikováno v:
Journal of applied toxicology : JAT. 35(9)
Drug-induced liver injury (DILI) is poorly predicted by single-cell-based assays, probably because of the lack of physiological interactions with other cells within the liver. An intact whole liver system such as one present in zebrafish larvae could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da324d271ee797649283b97cc0e47f12
https://pubmed.ncbi.nlm.nih.gov/25663337
https://pubmed.ncbi.nlm.nih.gov/25663337
Autor:
Miek Desmidt, Natalie Mesens, Marc Verhemeldonck, Ann Lampo, Geert R. Verheyen, Lieve Lammens, Jacky Van Gompel, Ronald De Vries, Siegrid Damsch, Sofie Starckx
Publikováno v:
Toxicologic pathology. 40(3)
To provide mechanistic insight in the induction of phospholipidosis and the appearance of the proposed biomarker di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate (BMP), rats were treated with 150 mg/kg amiodarone for 12 consecutive days and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cf06794f4ae2e441dea95f70cde54a
https://pubmed.ncbi.nlm.nih.gov/22291062
https://pubmed.ncbi.nlm.nih.gov/22291062