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Publikováno v:
Proc Natl Acad Sci U S A
Timely resolution of bacterial infections critically depends on phagocytosis of invading pathogens by polymorphonuclear neutrophil granulocytes (PMNs), followed by PMN apoptosis and efferocytosis. Here we report that bacterial DNA (CpG DNA) and mitoc
Autor:
Janos G Filep, Natalie Edner, Everton de Oliveira Lima Dos Santos, Meriem Sekheri, Driss El Kebir
Publikováno v:
The Journal of Immunology. 198:129.1-129.1
Neutrophil dysfunction, resulting in delayed apoptosis and inefficient bacterial clearance, is a characteristic feature of severe pathologies, including sepsis and cystic fibrosis. Human neutrophils detect and respond to bacterial DNA (CpG DNA) throu