Pharmacodynamic evaluation of L-carnitine and piracetam in muscle injury induced by the chronic use of simvastatin

Autor: Paulo César Pires Rosa, Gustavo D. Mendes, Jaime O. Ilha, Gilberto De Nucci, Natalicia J. Antunes, Renan Marcel Bonilha Dezena, Ronilson Agnaldo Moreno, Rafael Campos

Publikováno v: Int. Journal of Clinical Pharmacology and Therapeutics. 58:482-490

Objectives To evaluate the effect of L-carnitine and piracetam on the muscle injury induced by simvastatin in healthy male subjects during the therapy with oral doses of 10 mL of a solution containing L-carnitine 100 mg/mL + piracetam 80 mg/mL (test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fd5b4e9132bb82bfc5d19a4f16a327
https://doi.org/10.5414/cp203496

Randomized, double‐blind, phase III clinical study of a novel nanotechnological topical anesthetic formulation containing lidocaine 25 mg/g and prilocaine 25 mg/g (nanorap) in skin phototypes I–III patients with ablative fractional CO 2 laser treatment indication in the forehead

Autor: Cintia Aparecida Rodrigues Santiago Gobbato, André Alves Moraes Gobbato, Gilberto De Nucci, Tainah B. Magalhães, Natalicia J. Antunes, Jaime O. Ilha, Gustavo D. Mendes, Ronilson Agnaldo Moreno

Publikováno v: Lasers in Surgery and Medicine. 51:609-615

Background and objectives Nanotechnology may increase the speed of penetration into the skin. This study evaluated the efficacy, safety, and pharmacokinetics of a novel topical anesthetic nanocapsule formulation (2 g) containing 2.5% lidocaine and 2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2499aec144a1db06fc3e3a285c4a090e
https://doi.org/10.1002/lsm.23071

Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential

Autor: André Felipe Nahoum, Gilberto De Nucci, Jaime O. Ilha, André Warnke, Ronilson Agnaldo Moreno, Ralph-Steven Wedemeyer, Raimundo Vieira de Oliveira Filho, Natalicia J. Antunes

Publikováno v: The European journal of contraceptionreproductive health care : the official journal of the European Society of Contraception. 26(3)

To evaluate the pharmacokinetics and pharmacodynamics of oestriol (E3) and trimegestone (TMG) in healthy women after application of three different vaginal rings over 21 days. The vaginal rings had a nominal delivery rate of 0.413/0.050 mg/day (Test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8345e81df25279bd2b33a108c34d3d
https://pubmed.ncbi.nlm.nih.gov/33645377

Determination of dopamine, noradrenaline, and adrenaline in Krebs–Henseleit solution by liquid chromatography coupled with tandem mass spectrometry and measurement of their basal release from Chelonoidis carbonaria aortae in vitro

Autor: Manoel Odorico de Moraes, Rafael Campos, José Britto-Júnior, Fernanda Fernandes, Maria Elisabete Amaral de Moraes, M. Sucupira, Gustavo D. Mendes, Gilberto De Nucci, Natalicia J. Antunes

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

This study presented for the first time the development and validation of a sensitive method for quantification of dopamine, noradrenaline, and adrenaline in Krebs-Henseleit solution by LC-tandem mass spectrometry. Aliquots of 2.0 mL calibrators, qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bed8de4a92d5068f4feecc64a6e673
https://doi.org/10.1002/bmc.4978

Quantification of Plasma and Urine Thymidine and 2’-Deoxyuridine by LC-MS/MS for the Pharmacodynamic Evaluation of Erythrocyte Encapsulated Thymidine Phosphorylase in Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy

Autor: Max Hecht, Karin Kipper, Sema Kalkan Uçar, Emma L. Blakely, Natalicia J. Antunes, Andrew M. Schaefer, Michelle Levene, Bridget E. Bax, Lynette D. Fairbanks

Publikováno v: Journal of Clinical Medicine; Volume 9; Issue 3; Pages: 788
Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 9, Iss 3, p 788 (2020)

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in TYMP, leading to a deficiency in thymidine phosphorylase and a subsequent systemic accumulation of thymidine and 2'-deoxyuridine. Erythrocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5fb98be9cef84bd253ed9ce29cf2e9