Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling

Autor: Charlotte Maillot, Natalia De Isla, Celine Loubiere, Dominique Toye, Eric Olmos

Publikováno v: Biotechnology and Bioengineering. 119:3537-3548

Mesenchymal stem cell (MSC) products are promising therapeutic candidates to treat a wide range of pathologies. The successful commercialization of these cell therapies will, however, depend on the development of reproducible cell production processe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22974d1fc3b6fffac0a1fc67b750dba
https://doi.org/10.1002/bit.28228

MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis

Autor: Francesca Diomede, Maria Zingariello, Marcos F.X.B. Cavalcanti, Ilaria Merciaro, Jacopo Pizzicannella, Natalia de Isla, Sergio Caputi, Patrizia Ballerini, Oriana Trubiani

Publikováno v: European Journal of Histochemistry, Vol 61, Iss 2 (2017)

The present study was aimed at investigating whether human Periodontal Ligament Stem Cells (hPDLSCs) were capable of sensing and reacting to lipopolysaccharide from Porphyromonas gingivalis (LPS-G) which is widely recognized as a major pathogen in th

Externí odkaz: https://doaj.org/article/a41f2bbd4f2640a0a37fc3ca53f3c02a

A new perfusion mode of culture for WJ‐MSCs expansion in a stirred and online monitored bioreactor

Autor: Bruno Ebel, Emmanuel Guedon, Fanny Gallo, Eric Olmos, Caroline Sion, Natalia de Isla, Dima Ghannoum, Isabelle Chevalot

Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering, Wiley, 2021, 118 (11), pp.4453-4464. ⟨10.1002/bit.27914⟩

Since a clinical dose requires a minimum of 106 cells per kilogram of patients, it is therefore crucial to develop a scalable method of production of Wharton Jelly Mesenchymal stem cells (WJ-MSCs) with maintained inner characteristics. Scalable expan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3497e58691b365e936e046d119eea813
https://hal.archives-ouvertes.fr/hal-03505287

Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages

Autor: Zhihong Xu, Lulu Lin, Yuxuan Fan, Céline Huselstein, Natalia De Isla, Xiaohua He, Yun Chen, Yinping Li

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4333

The secretome from hypoxia-preconditioned mesenchymal stem cells (MSCs) has been shown to promote resolution of inflammation and alleviate acute lung injury (ALI) through its immunomodulatory function. However, the effects of consecutive hypoxic cult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce4bd73a697dce98e5055de3aeb6250
https://doi.org/10.3390/ijms23084333

Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done

Autor: Xiong Wang, Natalia de Isla, Rachid Rahouadj, Cédric Laurent, Xing Liu

Publikováno v: Journal of Cellular Immunotherapy
Journal of Cellular Immunotherapy, Shanghai Hengrun Biomedical Technology Research Institute. Production and hosting by Elsevier B.V., 2018, 4 (1), pp.4-9. ⟨10.1016/j.jocit.2018.09.002⟩
Journal of Cellular Immunotherapy, Vol 4, Iss 1, Pp 4-9 (2018)

Tissue engineering is a promising alternative to current surgical methods for ligament repair. However, despite a large variety of reported scaffolds for ligament, tissue-engineered solutions struggle to reach the clinics. The issue of proposing a sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37dd0849cc98948cf34f59ae81d81c8
https://doi.org/10.1016/j.jocit.2018.09.002