Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Natalia Y. Kedishvili"'
Autor:
Kelli R. Goggans, Olga V. Belyaeva, Alla V. Klyuyeva, Jacob Studdard, Aja Slay, Regina B. Newman, Christine A. VanBuren, Helen B. Everts, Natalia Y. Kedishvili
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The hair follicle (HF) is a self-renewing adult miniorgan that undergoes drastic metabolic and morphological changes during precisely timed cyclic organogenesis. The HF cycle is known to be regulated by steroid hormones, growth factors and c
Externí odkaz:
https://doaj.org/article/178a885c5b3041828802ae186182adf6
Autor:
Olga V. Belyaeva, Alla V. Klyuyeva, Ansh Vyas, Wilhelm K. Berger, Laszlo Halasz, Jianshi Yu, Venkatram R. Atigadda, Aja Slay, Kelli R. Goggans, Matthew B. Renfrow, Maureen A. Kane, Laszlo Nagy, Natalia Y. Kedishvili
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/fe3e1010095d44f79e85b4d5d378ad56
Autor:
Jianfeng Li, Silvia Garavaglia, Zhaofeng Ye, Andrea Moretti, Olga V. Belyaeva, Alison Beiser, Md Ibrahim, Anna Wilk, Steve McClellan, Alla V. Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili, E. Alan Salter, Andrzej Wierzbicki, Marie E. Migaud, Steven J. Mullett, Nathan A. Yates, Carlos J. Camacho, Menico Rizzi, Robert W. Sobol
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Using in silico modeling, Li et al. identify a selective inhibitor for aldehyde dehydrogenase isoform ALDH1A3, which is highly expressed in mesenchymal glioma stem cells and therefore a potential drug target. They solve the structure of the ALDH1A3/M
Externí odkaz:
https://doaj.org/article/d4ab4bd6ea5d4fe5ac3e294cb177d517
Autor:
Yanling Ma, Suman Karki, Philip M. Brown, Dennis D. Lin, Maren C. Podszun, Wenchang Zhou, Olga V. Belyaeva, Natalia Y. Kedishvili, Yaron Rotman
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1400-1409 (2020)
Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease development. Mutant HSD17B13 variants devoid of enzymatic function have
Externí odkaz:
https://doaj.org/article/5fdd4d17da154217beb7bd53705cafbf
Autor:
Liye Suo, Christine VanBuren, Eylul Damla Hovland, Natalia Y. Kedishvili, John P. Sundberg, Helen B. Everts
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Hair follicles cycle through periods of growth (anagen), regression (catagen), rest (telogen), and release (exogen). Telogen is further divided into refractory and competent telogen based on expression of bone morphogenetic protein 4 (BMP4) and wingl
Externí odkaz:
https://doaj.org/article/9102eb60556d4b078ae28ef0e2bc37b0
Autor:
Natalia Y. Kedishvili
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1744-1760 (2013)
All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous physiological processes. The concentration of retinoic acid in the cells is tightly regulated, but the exact mechanisms responsible for this regulation a
Externí odkaz:
https://doaj.org/article/3470785a59e34cb6bfd00c6cb605c0eb
Autor:
Venkatram R. Atigadda, Mahendra P. Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Rajesh Sinha, Olga V. Belyaeva, Chu-Fang Chou, Pi-Ling Chang, Natalia Y. Kedishvili, Clinton J. Grubbs, Matthew B. Renfrow, Donald D. Muccio, Craig A. Elmets, Mohammad Athar
Publikováno v:
J Med Chem
Compound 1 is a potent rexinoid that is highly effective in cancer chemoprevention but elevates serum triglycerides. In an effort to separate the lipid toxicity from the anticancer activity of 1, we synthesized four new analogs of rexinoid 1, of whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b40461637cc0f417346b98efcc6e89d
https://doi.org/10.1021/acs.jmedchem.2c00735
https://doi.org/10.1021/acs.jmedchem.2c00735
Autor:
Olga V. Belyaeva, Ivis F. Chaple, Lizhi Wu, Mark K. Adams, Natalia Y. Kedishvili, Kirill M. Popov, Katelyn Dunigan-Russell
Publikováno v:
Biochem J
The hetero-oligomeric retinoid oxidoreductase complex (ROC) catalyzes the interconversion of all-trans-retinol and all-trans-retinaldehyde to maintain the steady-state output of retinaldehyde, the precursor of all-trans-retinoic acid that regulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d0b9a7e9635be2e63b086200bc1e3f
https://doi.org/10.1042/bcj20210589
https://doi.org/10.1042/bcj20210589
Autor:
Igor A. Butovich, Amber Wilkerson, Kelli R. Goggans, Olga V. Belyaeva, Natalia Y. Kedishvili, Seher Yuksel
Publikováno v:
Journal of Biological Chemistry. 299:104725
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b70fecfb9a15cbe749a1da4da174ef9a
https://doi.org/10.1016/j.jbc.2023.104725
https://doi.org/10.1016/j.jbc.2023.104725
17‐Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet Injury
Autor:
Bin Gao, Joselyn N. Allen, Natalia Y. Kedishvili, Philip M. Brown, Dennis D. Lin, Maren C. Podszun, Regina Umarova, Dechun Feng, Olga V. Belyaeva, Yanling Ma, Jason Roszik, David E. Kleiner, Oksana Gavrilova, Yaron Rotman, Jing Ma
Publikováno v:
Hepatology
Background and aims 17-Beta hydroxysteroid dehydrogenase 13 (HSD17B13) is genetically associated with human nonalcoholic fatty liver disease (NAFLD). Inactivating mutations in HSD17B13 protect humans from NAFLD-associated and alcohol-associated liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ba83a588bfcd957f52f9187bd5da7e
https://doi.org/10.1002/hep.31517
https://doi.org/10.1002/hep.31517