Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Natalia Vykhodtseva"'
Autor:
Nathan McDannold, Yongzhi Zhang, Jeffrey G. Supko, Chanikarn Power, Tao Sun, Natalia Vykhodtseva, Alexandra J. Golby, David A. Reardon
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical transcranial MRI-guided focused ultrasound (TcMRgFUS) device and evaluated enhanced delivery of irinotecan chemotherapy to the brain and a rat gli
Externí odkaz:
https://doaj.org/article/dbbc08312ca148409c6d22571344c92a
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45783 (2012)
The ability of ultrasonically-induced oscillations of circulating microbubbles to permeabilize vascular barriers such as the blood-brain barrier (BBB) holds great promise for noninvasive targeted drug delivery. A major issue has been a lack of contro
Externí odkaz:
https://doaj.org/article/8949e4d3885c45ae8dd6bbe5e117b842
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42754 (2012)
The blood-retinal barrier (BRB) prevents most systemically-administered drugs from reaching the retina. This study investigated whether burst ultrasound applied with a circulating microbubble agent can disrupt the BRB, providing a noninvasive method
Externí odkaz:
https://doaj.org/article/528b034c424c46f9b62fd2bb5be12cbc
PDF file - 107K, Figure S1: (A) Experimental setup. (B) Beam steering pattern used during volumetric sonication. The order of the nine "subsonications" is indicated. (C) Pulsing scheme used during volumetric sonication. Three 50 s sonications were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5858810265fac8a2cb6830d95b5704b3
https://doi.org/10.1158/0008-5472.22392546
https://doi.org/10.1158/0008-5472.22392546
PDF file - 130K, Figure S3: MRI and histological effects of sonication delivered at an exposure level that produced tissue damage in addition to BBB disruption. (A) T2*-weighted imaging after volumetric sonication (nine locations in a 3�3 grid) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411364f6c8b9704dd4355745a83f3f22
https://doi.org/10.1158/0008-5472.22392540
https://doi.org/10.1158/0008-5472.22392540
PDF file - 349K, Figure S2: Histology after volumetric sonication in the hippocampus/LGN in monkey 4. This target was sonicated ~2h before the animal was sacrificed and in seven prior sessions over several months. (A) Contrast-enhanced T1-weighted MR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f286bea451c6b13ba2b8447886a527
https://doi.org/10.1158/0008-5472.22392543
https://doi.org/10.1158/0008-5472.22392543
PDF file - 75K, Supplementary Methods including focused ultrasound system calibration, USCA infusion protocol and MRI sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bed020d177a68091c6757da0e7df36
https://doi.org/10.1158/0008-5472.22392534
https://doi.org/10.1158/0008-5472.22392534
Autor:
Yongzhi Zhang, Chanikarn Power, Tao Sun, Alexandra J. Golby, Nathan McDannold, Jeffrey G. Supko, Natalia Vykhodtseva, David A. Reardon
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
We investigated controlled blood-brain barrier (BBB) disruption using a low-frequency clinical transcranial MRI-guided focused ultrasound (TcMRgFUS) device and evaluated enhanced delivery of irinotecan chemotherapy to the brain and a rat glioma model
Publikováno v:
Ultrasound in Medicine & Biology. 43:469-475
Numerous researchers are investigating the use of microbubble-enhanced ultrasound to disrupt the blood-brain barrier (BBB) disruption and deliver drugs to the brain. This study investigated the impact of using oxygen as a carrier gas for anesthesia o