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Autor:
Natalia V. Ortiz-Zacarias, Ingrid M C Kamerling, Erik B Wilms, Henri A. Verbrugh, Cees van Nieuwkoop, Anneke C. Dijkmans, Daan J Touw, W. Birkhoff
Publikováno v:
Therapeutic Drug Monitoring, 37(4), 419-427
Therapeutic Drug Monitoring, 37(4), 419-427. Lippincott Williams & Wilkins
Therapeutic Drug Monitoring, 37(4), 419-427. Lippincott Williams & Wilkins
Colistin (polymyxin E) is a positively charged deca-peptide antibiotic that disrupts the integrity of the outer membrane of the cell wall of gram-negative bacteria by binding to the lipid A moiety of lipopolysaccharides, resulting in cell death. The