Výsledky vyhledávání - "Natalia V. Kostereva"

Loss of Etv5 Decreases Proliferation and RET Levels in Neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis1

Autor: Kenneth M. Murphy, Gail C. Ekman, Chris E. Hostetler, Natalia V. Kostereva, Daryl D. Meling, Marie Claude Hofmann, Kay Carnes, Gaurav Tyagi, Michael D. Griswold, Paul S. Cooke, Carla M.K. Morrow, Rex A. Hess

Publikováno v: Biology of Reproduction. 81:258-266

Mice that are ets variant gene 5 (ETV5) null (Etv5 � /� ) undergo the first wave of spermatogenesis but lose all spermatogonial stem cells (SSCs) during this time. The SSC loss in Etv5 � /� mice begins during the neonatal period, suggesting a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::362d736f7c41738e9b312a230dbf9195
https://doi.org/10.1095/biolreprod.108.075200

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Direct Transdifferentiation of Stem/Progenitor Spermatogonia Into Reproductive and Nonreproductive Tissues of All Germ Layers

Autor: Gail C. Ekman, Liz Simon, Zhen Zhang, Rex A. Hess, Marie Claude Hofmann, Paul S. Cooke, Natalia V. Kostereva

Publikováno v: Stem Cells. 27:1666-1675

Pluripotent stem cells have great clinical potential for tissue regeneration/repair in humans. The use of embryonic stem (ES) cells is ethically controversial, leading to searches for other sources of pluripotent stem cells. Testicular spermatogonial

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https://doi.org/10.1002/stem.93

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Role of Microsomal Retinol/Sterol Dehydrogenase-Like Short-Chain Dehydrogenases/Reductases in the Oxidation and Epimerization of 3α-Hydroxysteroids in Human Tissues

Autor: Natalia V. Kostereva, Bibie M. Chronwall, Olga V. Belyaeva, Natalia Y. Kedishvili, Karen S. SantaCruz, Amy L. Clark, Sergei V. Chetyrkin

Publikováno v: Endocrinology. 148:2148-2156

Allopregnanolone (ALLO) and androsterone (ADT) are naturally occurring 3alpha-hydroxysteroids that act as positive allosteric regulators of gamma-aminobutyric acid type A receptors. In addition, ADT activates nuclear farnesoid X receptor and ALLO act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5591af3cf77903903b4baa44d129f7b0
https://doi.org/10.1210/en.2006-1491

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Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

Autor: Natalia V. Kostereva, Olga V. Belyaeva, Elena V. Shabrova, Anton V. Stetsenko, F. Xavier Ruiz, Jaume Farrés, Xavier Parés, Oriol Gallego, Sergio Porté, Natalia Y. Kedishvili

Publikováno v: Biochemical Journal. 399:101-109

Retinoic acid biosynthesis in vertebrates occurs in two consecutive steps: the oxidation of retinol to retinaldehyde followed by the oxidation of retinaldehyde to retinoic acid. Enzymes of the MDR (medium-chain dehydrogenase/reductase), SDR (short-ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40249fbbc693f1704f27e75196d5ace9
https://doi.org/10.1042/bj20051988

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Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis

Autor: Gaurav, Tyagi, Kay, Carnes, Carla, Morrow, Natalia V, Kostereva, Gail C, Ekman, Daryl D, Meling, Chris, Hostetler, Michael, Griswold, Kenneth M, Murphy, Rex A, Hess, Marie-Claude, Hofmann, Paul S, Cooke

Publikováno v: Biology of reproduction. 81(2)

Mice that are ets variant gene 5 (ETV5) null (Etv5(-/-)) undergo the first wave of spermatogenesis but lose all spermatogonial stem cells (SSCs) during this time. The SSC loss in Etv5(-/-) mice begins during the neonatal period, suggesting a role for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe4f04ea77baab3a498dd3f33efdb155
https://pubmed.ncbi.nlm.nih.gov/19369650

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Regulation of the spermatogonial stem cell niche

Autor: Marie Claude Hofmann, Natalia V. Kostereva

Publikováno v: Reproduction in domestic animals = Zuchthygiene. 43

Spermatogonial stem cells (SSCs) reside within specialized microenvironments called 'niches', which are essential for their maintenance and self-renewal. In the mammalian testis, the main components of the niche include the Sertoli cell, the growth f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880985a05e0b7c82abc6e1805a94041e
https://pubmed.ncbi.nlm.nih.gov/18638151

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Microsomal Short‐Chain Dehydrogenases/Reductases (SDRs) in the Oxidation and Epimerization of 3α‐Hydroxysteroids

Autor: Natalia V. Kostereva, Olga V. Belyaeva, Sergei V. Chetyrkin, Natalia Y. Kedishvili, Bibie M. Chronwall

Publikováno v: The FASEB Journal. 21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e5949a7b231c259074d3a04a89ca4f6
https://doi.org/10.1096/fasebj.21.5.a663-a

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Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation

Autor: Martin Dym, Marie Claude Hofmann, Natalia V. Kostereva, Laura K. Braydich-Stolle

Publikováno v: Developmental Biology. (1):34-45

Spermatogonial stem cells are required for the initiation of spermatogenesis and the continuous production of sperm. In addition, they can acquire pluripotency and differentiate into derivatives of the three embryonic germ layers when cultured in the

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