Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Natalia V. Dobryakova"'
Publikováno v:
Polymers, Vol 16, Iss 17, p 2468 (2024)
New carriers for protein immobilization are objects of interest in various fields of biomedicine. Immobilization is a technique used to stabilize and provide physical support for biological micro- and macromolecules and whole cells. Special efforts h
Externí odkaz:
https://doaj.org/article/5d6d278d181a43da8fee8832ff1d1cc7
Autor:
Natalia V. Dobryakova, Maria V. Dumina, Alexander A. Zhgun, Marina V. Pokrovskaya, Svetlana S. Aleksandrova, Dmitry D. Zhdanov, Elena V. Kudryashova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4174 (2024)
This study investigated the effect of polycationic and uncharged polymers (and oligomers) on the catalytic parameters and thermostability of L-asparaginase from Thermococcus sibiricus (TsA). This enzyme has potential applications in the food industry
Externí odkaz:
https://doaj.org/article/65b28ca77a0947c4856f2b5c26a3d8e2
Publikováno v:
Gels, Vol 10, Iss 3, p 157 (2024)
We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentra
Externí odkaz:
https://doaj.org/article/69bd1d1047674d39ac46270001b94699
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8023 (2023)
Oncological diseases are difficult to treat even with strong drugs due to development the multidrug resistance (MDR) of cancer cells. A strategy is proposed to increase the efficiency and selectivity of cytotoxic agents against cancer cells to engage
Externí odkaz:
https://doaj.org/article/df91744d69a146c4b1e22dc413edeb3c
Autor:
Natalia V. Dobryakova, Dmitry D. Zhdanov, Nikolay N. Sokolov, Svetlana S. Aleksandrova, Marina V. Pokrovskaya, Elena V. Kudryashova
Publikováno v:
Applied Sciences, Vol 13, Iss 5, p 3373 (2023)
L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic acid. Due to the shortcomings of existing L-asparaginases from Esherichia coli (EcA) and Erwi
Externí odkaz:
https://doaj.org/article/a2972d5afe564446a78c39aef6426168
Autor:
Natalia V. Dobryakova, Dmitry D. Zhdanov, Nikolay N. Sokolov, Svetlana S. Aleksandrova, Marina V. Pokrovskaya, Elena V. Kudryashova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 406 (2022)
L-asparaginases (L-ASNases, EC 3.5.1.1) are a family of enzymes that are widely used for the treatment of lymphoblastic leukemias. L-ASNase from Rhodospirillum rubrum (RrA) has a low molecular weight, low glutaminase activity, and low immunogenicity,
Externí odkaz:
https://doaj.org/article/0c06139e142744e68451b684a8a3e0ff