Výsledky vyhledávání - "Natalia Sushkova"

The SYNERGY biodegradable polymer everolimus eluting coronary stent: Porcine vascular compatibility and polymer safety study

Autor: Kimberly A. Robertson, Angela Marks, Kimberly J. Berg, Douglas E. Pennington, Natalia Sushkova, Gregory J. Wilson, Yen-Lane Chen, David Knapp, Aaron Foss, Keith D. Dawkins, Barbara Huibregtse, Steve P Hawley, Michael J. Eppihimer

Publikováno v: Catheterization and Cardiovascular Interventions. 86:E247-E257

Aims SYNERGY is a novel platinum chromium alloy stent that delivers abluminal everolimus from an ultrathin poly-lactide-co-glycide (PLGA) biodegradable polymer. This study evaluated the in vivo degradation of the polymer coating, everolimus release t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05cea720b5cb281d572f5c953d182a3f
https://doi.org/10.1002/ccd.25993

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Impact of bioresorbable versus permanent polymer on longterm vessel wall inflammation and healing: a comparative drug-eluting stent experimental study

Autor: Jennifer McGregor, Steven P Hawley, Gregory J. Wilson, Masahiko Shibuya, Gerard Conditt, Keith D. Dawkins, Serge D Rouselle, Michael J. Eppihimer, Juan F. Granada, Barbara Huibregtse, Natalia Sushkova

Publikováno v: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 13(14)

AIMS Drug-eluting stents (DES) have evolved to using bioresorbable polymers as a method of drug delivery. The impact of bioresorbable polymer on long-term neointimal formation, inflammation, and healing has not been fully characterised. This study ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9c50744493a554a18390494e95af20
https://pubmed.ncbi.nlm.nih.gov/29465405

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Vasomotor function and re-endothelialisation after implantation of biodegradable abluminal polymer coated paclitaxel-eluting stents in rabbit iliac arteries: a time-course study

Autor: Dawn Winsor-Hines, Dongming Hou, Nicolas Chronos, Michael J. Eppihimer, Spencer B. King, Natalia Sushkova, Keith D. Dawkins, Xinhua Yin, Jack P. Chen, Takamitsu Nakamura, Barbara Huibregtse

Publikováno v: EuroIntervention. 8:493-500

AIMS To evaluate the time-course of vasomotor function and re-endothelialisation after implantation of a novel platinum-chromium (PtCr) abluminal biodegradable polymer-coated paclitaxel-eluting stent (PES, Labcoat Element) in rabbit iliac arteries. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4a8192ea6495a4da3a8fee2cdc589d
https://doi.org/10.4244/eijv8i4a77

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Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury

Autor: Steve Tam, Qin Wang, Adrian Huang, Desiree H.H. Tsao, Natalia Sushkova, Michael Dennis Lowe, Gray D. Shaw, Patricia W. Bedard, Li Di, Boris Tchernychev, James C. Keith, Neelu Kaila, Robert G. Schaub, Kristin Janz, Valerie Clerin, Alessandro Moretto

Publikováno v: Journal of Medicinal Chemistry. 53:6003-6017

Previously, we reported the discovery of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor. It is active in a variety of animal models of cardiovascular disease. Compound 1a has also been shown to be well tole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037abec3fb0ac922950e891045ae2fb2
https://doi.org/10.1021/jm9013696

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Characterization of the Novel P-Selectin Inhibitor PSI-697 [2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] Quinoline-4-carboxylic acid] in Vitro and in Rodent Models of Vascular Inflammation and Thrombosis

Autor: Robert G. Schaub, Valerie Clerin, David L. Crandall, Gray D. Shaw, Thomas M. Antrilli, Natalia Sushkova, Laura L. Carter, Christine Resmini, Patricia W. Bedard, Kristin Janz, James K. Hennan, Silvano DeBernardo, James C. Keith, Neelu Kaila, Qin Wang, Boris Tchernychev

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 324:497-506

P-selectin plays a significant and well documented role in vascular disease by mediating leukocyte and platelet rolling and adhesion. This study characterizes the in vitro activity, pharmacokinetic properties, and the anti-inflammatory and antithromb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3f0969afcb1b3977097a3ac40ce1a3
https://doi.org/10.1124/jpet.107.128124

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Relative Contributions of α4and αLIntegrins to IL-4-Induced Leukocyte Rolling and Adhesion

Autor: Michael J. Eppihimer, Natalia Sushkova, Mark C. Lavigne

Publikováno v: Microcirculation. 11:655-668

To delineate the relative contributions of alpha4 and alphaL to mediate interleukin-4 (IL-4) induced leukocyte rolling, and the subsets of leukocytes that use these pathways to adhere.Intravital microscopy was used to examine leukocytes in venules of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cec1e81b639a0170f6b5085ddccc68
https://doi.org/10.1080/10739680490517677

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Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels

Autor: Andreas Margraf, Alina Steppner, Claudia Nussbaum, Lubor Borsig, Angela R.M. Kurz, Orsolya Genzel-Boroviczény, Markus Sperandio, Elizabeth J. Quackenbush, Natalia Sushkova, Monika Pruenster, Natalie Schweiger, Udo Jeschke, Ulrich H. von Andrian, Nele Krajewski, Johannes Altstätter, Stephan Schmid, Ildiko Boros, David Frommhold

Publikováno v: Blood. 121(21)

In adult mammals, leukocyte recruitment follows a well-defined cascade of adhesion events enabling leukocytes to leave the circulatory system and transmigrate into tissue. Currently, it is unclear whether leukocyte recruitment proceeds in a similar f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbe31d1ca129dd36718c7c2bebddc03
https://pubmed.ncbi.nlm.nih.gov/23704046

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2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists

Autor: James C. Keith, Valerie Clerin, Desiree H.H. Tsao, Patricia W. Bedard, Silvano DeBernardo, Tam Steve Yik-Kai, Kristin Janz, Alessandro Moretto, Raymond T. Camphausen, Gray D. Shaw, Robert G. Schaub, Qin Wang, Adrian Huang, Natalia Sushkova, Neelu Kaila

Publikováno v: Journal of medicinal chemistry. 50(1)

P-selectin-PSGL-1 interaction causes rolling of leukocytes on the endothelial cell surface, which subsequently leads to firm adherence and leukocyte transmigration through the vessel wall into the surrounding tissues. P-selectin is upregulated on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc2901446f22e4add8ca889571b3870
https://pubmed.ncbi.nlm.nih.gov/17201409

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