Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Natalia Shulzhenko"'
Autor:
Stephen J. Gaudino, Ankita Singh, Huakang Huang, Jyothi Padiadpu, Makheni Jean-Pierre, Cody Kempen, Tej Bahadur, Kiyoshi Shiomitsu, Richard Blumberg, Kenneth R. Shroyer, Semir Beyaz, Natalia Shulzhenko, Andrey Morgun, Pawan Kumar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract IL-22 is critical for ameliorating obesity-induced metabolic disorders. However, it is unknown where IL-22 acts to mediate these outcomes. Here we examine the importance of tissue-specific IL-22RA1 signaling in mediating long-term high fat d
Externí odkaz:
https://doaj.org/article/dff7637b26b44e1ba5afa90bb82f7db3
Autor:
Jyothi Padiadpu, Manuel Garcia‐Jaramillo, Nolan K Newman, Jacob W Pederson, Richard Rodrigues, Zhipeng Li, Sehajvir Singh, Philip Monnier, Giorgio Trinchieri, Kevin Brown, Amiran K Dzutsev, Natalia Shulzhenko, Donald B Jump, Andrey Morgun
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive.
Externí odkaz:
https://doaj.org/article/d61e92523d9e4acf87080e7f0b5b8143
Autor:
Jyothi Padiadpu, Melinda H. Spooner, Zhipeng Li, Nolan Newman, Christiane V. Löhr, K. Denise Apperson, Amiran Dzutsev, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun, Donald B. Jump
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
BackgroundNonalcoholic fatty liver disease (NAFLD) is a global health problem. Identifying early gene indicators contributing to the onset and progression of NAFLD has the potential to develop novel targets for early therapeutic intervention. We repo
Externí odkaz:
https://doaj.org/article/46edeae843a44a259ad0dbc2f51e195b
Autor:
Amy L Seufert, James W Hickman, Ste K Traxler, Rachael M Peterson, Trent A Waugh, Sydney J Lashley, Natalia Shulzhenko, Ruth J Napier, Brooke A Napier
Publikováno v:
eLife, Vol 11 (2022)
Trained immunity is an innate immune memory response that is induced by a primary inflammatory stimulus that sensitizes monocytes and macrophages to a secondary pathogenic challenge, reprogramming the host response to infection and inflammatory disea
Externí odkaz:
https://doaj.org/article/11ab3fcbf7ef42cc9ecc00140c2d5947
Autor:
Richard R. Rodrigues, Manoj Gurung, Zhipeng Li, Manuel García-Jaramillo, Renee Greer, Christopher Gaulke, Franziska Bauchinger, Hyekyoung You, Jacob W. Pederson, Stephany Vasquez-Perez, Kimberly D. White, Briana Frink, Benjamin Philmus, Donald B. Jump, Giorgio Trinchieri, David Berry, Thomas J. Sharpton, Amiran Dzutsev, Andrey Morgun, Natalia Shulzhenko
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Western diet (WD) is one of the major culprits of metabolic disease including type 2 diabetes (T2D) with gut microbiota playing an important role in modulating effects of the diet. Herein, we use a data-driven approach (Transkingdom Network
Externí odkaz:
https://doaj.org/article/2d75b1d838834d4e88d47f7baca85691
Autor:
Payel Kundu, Keaton Stagaman, Kristin Kasschau, Sarah Holden, Natalia Shulzhenko, Thomas J. Sharpton, Jacob Raber
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
The gut microbiome and the gut brain axis are potential determinants of Alzheimer’s disease (AD) etiology or severity and gut microbiota might coordinate with the gut-brain axis to regulate behavioral phenotypes in AD mouse models. Using 6-month-ol
Externí odkaz:
https://doaj.org/article/7c9a92eda76c45cebaa06a211bd15535
Autor:
Heather M. Kahalehili, Nolan K. Newman, Jamie M. Pennington, Siva K. Kolluri, Nancy I. Kerkvliet, Natalia Shulzhenko, Andrey Morgun, Allison K. Ehrlich
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The diet represents one environmental risk factor controlling the progression of type 1 diabetes (T1D) in genetically susceptible individuals. Consequently, understanding which specific nutritional components promote or prevent the development of dis
Externí odkaz:
https://doaj.org/article/ace1092cb71243c69e2fe2ae63f268e9
Autor:
Manoj Gurung, Zhipeng Li, Hannah You, Richard Rodrigues, Donald B Jump, Andrey Morgun, Natalia Shulzhenko
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic rev
Externí odkaz:
https://doaj.org/article/8d904ed4cd154c21816da6edc9095e9f
Autor:
Renee L. Greer, Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, Alexi A. Schoenborn, Everton P. Gomes, Alexandre C. Pereira, Sandra R. G. Ferreira, Michael Yao, Ivan J. Fuss, Warren Strober, Aleksandra E. Sikora, Gregory A. Taylor, Ajay S. Gulati, Andrey Morgun, Natalia Shulzhenko
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to ha
Externí odkaz:
https://doaj.org/article/61494a965e404846a44ae00fc93376f4
Autor:
Isabelle E. Logan, Gerd Bobe, Cristobal L. Miranda, Stephany Vasquez-Perez, Jaewoo Choi, Malcolm B. Lowry, Thomas J. Sharpton, Andrey Morgun, Claudia S. Maier, Jan F. Stevens, Natalia Shulzhenko, Adrian F. Gombart
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 520 (2020)
A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesi
Externí odkaz:
https://doaj.org/article/178af5bf71a84aa290ad54d28a43a9f7