Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Natalia Shpiro"'
Autor:
Abigail Brewer, Jin-Feng Zhao, Rotimi Fasimoye, Natalia Shpiro, Thomas J. Macartney, Nicola T. Wood, Melanie Wightman, Dario R. Alessi, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110423- (2024)
Summary: TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases, including fibrosis and cancer. TGF-β transcriptional responses are controlled b
Externí odkaz:
https://doaj.org/article/29d5d7de42d54273bca16ac8b4f72fb9
Autor:
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110432- (2024)
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplas
Externí odkaz:
https://doaj.org/article/06e99590560f4d84a989e659c12d87bb
Autor:
Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos delFresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz‐Ezquerro, Ana Cuenda
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 5, Pp n/a-n/a (2018)
Abstract Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drug
Externí odkaz:
https://doaj.org/article/939e61b85a3b4a58b2f2dc2991a14ffb
Autor:
Xingui Liu, Alexia F. Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja S. Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian G. Ganley, Rui Moreira, Dario R. Alessi, Alessio Ciulli
Publikováno v:
Journal of the American Chemical Society. 144:16930-16952
Leucine-rich repeat kinase 2 (LRRK2) is one of the most promising targets for Parkinson's disease. LRRK2-targeting strategies have primarily focused on type 1 kinase inhibitors, which, however, have limitations as the inhibited protein can interfere
Publikováno v:
The Biochemical journal. 479(20)
SummaryADP-heptose activates the protein kinase ALPK1 triggering TIFA phosphorylation at Thr9, the recruitment of TRAF6 and the subsequent production of inflammatory mediators. Here, we demonstrate that ADP-heptose also stimulates the formation of Ly
Autor:
Xingui Liu, Alexia Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian Ganley, Rui Moreira, Dario Alessi, Alessio Ciulli
Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s Disease. LRRK2 targeting strategies have primarily focused on Type 1 kinase inhibitors, which however have limitations as the inhibited protein can interfere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::213a6be7c5453a5c33432f09907f7fdf
https://doi.org/10.26434/chemrxiv-2022-4gzm0-v2
https://doi.org/10.26434/chemrxiv-2022-4gzm0-v2
Autor:
Xingui Liu, Alexia Kalogeropulou, Sofia Domingos, Nikolai Makukhin, Raja Nirujogi, Francois Singh, Natalia Shpiro, Anton Saalfrank, Esther Sammler, Ian Ganley, Rui Moreira, Dario Alessi, Alessio Ciulli
Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most promising targets for Parkinson’s Disease. LRRK2 targeting strategies have primarily focused on Type 1 kinase inhibitors, which however have limitations as the inhibited pro-tein can interfere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769e2998e21086f46fc4df52f8b411fb
https://doi.org/10.26434/chemrxiv-2022-4gzm0
https://doi.org/10.26434/chemrxiv-2022-4gzm0
Publikováno v:
SSRN Electronic Journal.
Autor:
Luke M. Simpson, Lorraine Glennie, Abigail Brewer, Jin-Feng Zhao, Jennifer Crooks, Natalia Shpiro, Gopal P. Sapkota
Publikováno v:
Cell Chemical Biology. 29:1482-1504.e7
Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal degradation. PROTACs rely on endogenous cellular machinery to mediate POI degrad
Autor:
Hannah Tovell, Houjiang Zhou, Dario R. Alessi, Natalia Shpiro, Claire Crafter, Alessio Ciulli, Andrea Testa
Publikováno v:
ACS Chemical Biology
SGK3 is a PX domain containing protein kinase activated at endosomes downstream of class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of breast cancer cells to class 1 PI3K or Ak