Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Natalia Serrano-Aparicio"'
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 531 (2022)
20S proteasome is a main player in the protein degradation pathway in the cytosol, thus intervening in multiple pivotal cellular processes. Over the years the proteasome has emerged as a crucial target for the treatment of many diseases such as neuro
Externí odkaz:
https://doaj.org/article/d47f7efd78c04f66bf123ea30a650400
Publikováno v:
ACS Catalysis. 11:3575-3589
20S proteasome is the enzymatic core engine involved in the processes of cellular protein regulation, thus becoming a promising target inter alia in the therapy of many diseases. In this work, the mechanism of the irreversible inhibition of the β5 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017f4bf3029a9a7a69dbc43fdbab1265
https://doi.org/10.1021/acscatal.0c05313
https://doi.org/10.1021/acscatal.0c05313
Publikováno v:
European Journal of Medicinal Chemistry. 164:399-407
Proteasome deregulation has been related with several human diseases and, consequently, a detailed knowledge of its inhibition is essential for the design of efficient and selective drugs. The present paper is focused on the inhibition mechanism of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5193ccf53e53c29b4a63010d75a6041f
https://doi.org/10.1016/j.ejmech.2018.12.062
https://doi.org/10.1016/j.ejmech.2018.12.062
Publikováno v:
Serrano-Aparicio, Natalia Swiderek, Katarzyna Tuñón, Iñaki Moliner, Vicent Bertran, Joan 2021 Theoretical Studies of the Self Cleavage Pistol Ribozyme Mechanism Topics in Catalysis 65 505 516
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Repositori Universitat Jaume I
Universitat Jaume I
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Repositori Universitat Jaume I
Universitat Jaume I
Ribozymes are huge complex biological catalysts composed of a combination of RNA and proteins. Nevertheless, there is a reduced number of small ribozymes, the self-cleavage ribozymes, that are formed just by RNA and, apparently, they existed in cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5d3847f3812e203f7caace8e52c8e8
https://hdl.handle.net/10550/82433
https://hdl.handle.net/10550/82433
