Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Natalia Scaglia"'
1
Akademický článek
Prostate Cancer Progression: as a Matter of Fats
Autor: Natalia Scaglia, Yesica Romina Frontini-López, Giorgia Zadra
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Advanced prostate cancer (PCa) represents the fifth cause of cancer death worldwide. Although survival has improved with second-generation androgen signaling and Parp inhibitors, the benefits are not long-lasting, and new therapeutic approaches are s
Externí odkaz: https://doaj.org/article/ec23dfaf8258436fa8171d3f0c972fec
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2
Akademický článek
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
Autor: Giorgia Zadra, Cornelia Photopoulos, Svitlana Tyekucheva, Pedram Heidari, Qing Ping Weng, Giuseppe Fedele, Hong Liu, Natalia Scaglia, Carmen Priolo, Ewa Sicinska, Umar Mahmood, Sabina Signoretti, Neal Birnberg, Massimo Loda
Publikováno v: EMBO Molecular Medicine, Vol 6, Iss 4, Pp 519-538 (2014)
Abstract 5′AMP‐activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway.
Externí odkaz: https://doaj.org/article/169701ea71a24e44a3ef89b7a24c6d1f
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3
Akademický článek
Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK.
Autor: Natalia Scaglia, Jeffrey W Chisholm, R Ariel Igal
Publikováno v: PLoS ONE, Vol 4, Iss 8, p e6812 (2009)
Cancer cells activate the biosynthesis of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) in order to sustain an increasing demand for phospholipids with appropriate acyl composition during cell replication. We have previously show
Externí odkaz: https://doaj.org/article/fa3652aa1c2b4f8381972f4fc93ac233
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4
Supplementary Figure S1 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Autor: Massimo Loda, Angelo M. De Marzo, Jonathan McDunn, Natalia Scaglia, Denise Schultz, Stefano Cacciatore, Cornelia Photopoulos, Giorgia Zadra, Erzsébet Ravasz Regan, Joshua Rose, Saumyadipta Pyne, Carmen Priolo
(A) Box plots of phosphoAKT1 or MYC levels in low- or high-Gleason prostate tumors. (B) Representative cases of phosphoAKT1-high/MYC-low (orange box), phosphoAKT1-high/MYC-high (dark grey box), phosphoAKT1-low/MYC-high (green box) and phosphoAKT1-low
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d78977687279d169788e237befb0d7
https://doi.org/10.1158/0008-5472.22405985.v1
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10
De novo lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion. Implications for combined chemotherapy
Autor: Luciana Rodriguez Sawicki, Karina Andrea Garcia, Betina Córsico, Natalia Scaglia
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Cell Cycle
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Mitosis has been traditionally considered a metabolically inactive phase. We have previously shown, however, that extensive alterations in lipids occur as the cells traverse mitosis, including increased de novo fatty acid (FA) and phosphatidylcholine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acc4ac5c2a9e32b280f6ed47ad6c142
https://doi.org/10.1080/15384101.2019.1629792
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