Výsledky vyhledávání - "Natalia Saenz-Ponce"

Supplementary Table S1 from RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma

Autor: Nicholas A. Saunders, Fiona Simpson, Daniel D.E. Dantzic, Natalia Saenz-Ponce, Pamela Mukhopadhyay, Marcin Dzienis, Ana Cristina Vargas, Samuel Boros, Orla M. Gannon, Lilia Merida de Long, Mehlika Hazar-Rethinam

Supplementary Table S1: Differentially expressed genes (List A and List B combined) identified as E2F7-dependent cytotoxic sensitivity genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398de586f574df41d8f3c9f7b9c3bea9
https://doi.org/10.1158/1535-7163.22502265

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Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

Autor: Liliana Endo-Munoz, Haolu Wang, Sally Martin, Rebecca Macklin, Na Cai, Natalia Saenz Ponce, A. Cumming, Dorothy Loo, Kerry L. Inder, Rebecca E. Lane, Eleni Topkas, Nicholas A. Saunders

Publikováno v: Oncotarget

Osteosarcoma (OS) is the most common pediatric bone tumor and is associated with the emergence of pulmonary metastasis. Unfortunately, the mechanistic basis for metastasis remains unclear. Tumor-derived extracellular vesicles (EVs) have been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2860dd9aae7c4dba7124d71c2c4589b
https://doi.org/10.18632/oncotarget.9781

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Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas

Autor: Trinayan Kashyap, Mehlika Hazar-Rethinam, Nicholas A. Saunders, Benedict Panizza, Maarten Jacquemyn, Christian Argueta, Yosef Landesman, Dirk Daelemans, Samuel Boros, Rachael Pillay, Natalia Saenz-Ponce, Lilia Merida de Long, Orla M. Gannon

Publikováno v: Science translational medicine. 10(447)

Patient mortality rates have remained stubbornly high (40%) for the past 35 years in head and neck squamous cell carcinoma (HNSCC) due to inherent or acquired drug resistance. Thus, a critical issue in advanced SCC is to identify and target the mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01046ee7bbe39ec0f7e1b1daa761029
https://pubmed.ncbi.nlm.nih.gov/29950445

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RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma

Autor: Natalia Saenz-Ponce, Daniel D.E. Dantzic, Lilia Merida de Long, Orla M. Gannon, Mehlika Hazar-Rethinam, Ana Cristina Vargas, Pamela Mukhopadhyay, Fiona Simpson, Samuel Boros, Marcin Radoslaw Dzienis, Nicholas A. Saunders

Publikováno v: Molecular cancer therapeutics. 14(8)

We have previously shown that E2F7 contributes to drug resistance in head and neck squamous cell carcinoma (HNSCC) cells. Considering that dysregulation of responses to chemotherapy-induced cytotoxicity is one of the major reasons for treatment failu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd94a5c655dab29ec0c27506461e6b1
https://pubmed.ncbi.nlm.nih.gov/26018753

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Abstract 1213: Nuclear export of E2F7 in squamous cell carcinoma in an actionable event that reverses resistance to anthracyclines

Autor: Alexander Guminski, Alba Natalia Saenz Ponce, Yosef Landesman, Orla M. Gannon, Nicholas A. Saunders, Trinayan Kashyap

Publikováno v: Cancer Research. 77:1213-1213

Objectives and Background: Squamous cell carcinoma (SCC) of the skin or head and neck region is a major cause of cancer death in the western world. Patient with advanced SCC have few therapeutic options and SCC remains resistant to current treatments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d80a0fb543b32b072b35df94651e7f1a
https://doi.org/10.1158/1538-7445.am2017-1213

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