Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Natalia Sacilotto"'
Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Autor:
Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril AB Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, Jason S Carroll, Timothy L Bailey, Peter Koopman, Ralf Jauch, Matthew A Cooper, Yann Gambin, Mathias Francois
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/631c7b6dffdc4c4b823c7ff82a631d2f
Autor:
Fernando Cavalcanti, Elena Gonzalez-Rey, Mario Delgado, Clara P. Falo, Leyre Mestre, Carmen Guaza, Francisco O’Valle, Michele M. P. Lufino, Jordi Xaus, Cristina Mascaró, Serena Lunardi, Natalia Sacilotto, Paola Dessanti, David Rotllant, Xavier Navarro, Mireia Herrando-Grabulosa, Carlos Buesa, Tamara Maes
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1420 (2022)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of
Externí odkaz:
https://doaj.org/article/df089ff6678843aa91f71f1d603fc7ce
Autor:
Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril AB Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, Jason S Carroll, Timothy L Bailey, Peter Koopman, Ralf Jauch, Matthew A Cooper, Yann Gambin, Mathias Francois
Publikováno v:
eLife, Vol 6 (2017)
Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have yielded limited success
Externí odkaz:
https://doaj.org/article/1f3cf6e6ad3345a2bb95b0d0d5a753be
Autor:
Natalia Sacilotto, Josefa Castillo, Ángela L Riffo-Campos, Juana M Flores, Olivia Hibbitt, Richard Wade-Martins, Carlos López, M Isabel Rodrigo, Luis Franco, Gerardo López-Rodas
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132477 (2015)
The prognosis of hepatocellular carcinoma patients is usually poor, the size of tumors being a limiting factor for surgical treatments. Present results suggest that the overexpression of Gas1 (growth arrest specific 1) gene reduces the size, prolifer
Externí odkaz:
https://doaj.org/article/6fe8b18a1a6843d19fd8f8d2fb284d42
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23318 (2011)
BACKGROUND: Gas1 (growth arrest-specific 1) gene is known to inhibit cell proliferation in a variety of models, but its possible implication in regulating quiescence in adult tissues has not been examined to date. The knowledge of how Gas1 is regulat
Externí odkaz:
https://doaj.org/article/9936c5e480bc412fb941c2932a138e33
Autor:
Alberto Ortega, Tamara Maes, Alejandra Rodríguez-Gimeno, Natalia Sacilotto, Michele Matteo Pio Lufino, Cristina Mascaró, Robert Soliva, Carlos Buesa, Paola Dessanti, Jordi Salas
Publikováno v:
ACS Pharmacology & Translational Science. 4:1818-1834
Autor:
Natalia Sacilotto, Kira M. Chouliaras, Leonid L. Nikitenko, Yao Wei Lu, Martin Fritzsche, Marsha D. Wallace, Svanhild Nornes, Fernando García-Moreno, Sophie Payne, Esther Bridges, Ke Liu, Daniel Biggs, Indrika Ratnayaka, Shane P. Herbert, Zoltán Molnár, Adrian L. Harris, Benjamin Davies, Gareth L. Bond, George Bou-Gharios, John J. Schwarz, Sarah De Val
Publikováno v:
Genesdevelopment. 36(19-20)
In this study, Saccilotto et al. investigated the molecular connection between proangiogenic signals and downstream gene expression during angiogenesis. By characterizing a Dll4 enhancer directing expression to endothelial cells at the angiogenic fro
Autor:
Natalia Sacilotto, Serena Lunardi, Filippo Ciceri, Cristina Mascaro, Tamara Maes, Ana Limon, Douglas V. Faller
Publikováno v:
Cancer Research. 82:B025-B025
Lysine Specific Demethylase 1 (LSD1, also known as KDM1A) is a member of the FAD-containing family of lysine demethylases and is generally involved in repressing transcription by specifically removing methyl groups from mono- and di-methylated lysine
Autor:
Natalia, Sacilotto, Paola, Dessanti, Michele M P, Lufino, Alberto, Ortega, Alejandra, Rodríguez-Gimeno, Jordi, Salas, Tamara, Maes, Carlos, Buesa, Cristina, Mascaró, Robert, Soliva
Publikováno v:
ACS pharmacologytranslational science. 4(6)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymati
Autor:
Michele M.P. Lufino, Serena Lunardi, Natalia Sacilotto, Tamara Maes, Mireia Herrando-Grabulosa, David Rotllant, Carlos Buesa, Jordi Xaus, Paola Dessanti, Carmen Guaza, Xavier Navarro, Elena Gonzalez-Rey, Cristina Mascaró, Mario Delgado, F. L. Cavalcanti, Leyre Mestre
Background Vafidemstat (ORY-2001) is a clinical stage inhibitor of the Lysine Specific Demethylase KDM1A in development for treatment of neurodegenerative and psychiatric diseases. KDM1A demethylates H3K4me1/2 and together with the histone deacetylas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc502a6fe4bd89e62039ecf96871e3e
https://doi.org/10.21203/rs.3.rs-114482/v4
https://doi.org/10.21203/rs.3.rs-114482/v4