Data from Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Autor: Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa

Purpose:BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development of targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34135ca0a46fae703101f62ea39fe83c
https://doi.org/10.1158/1078-0432.c.6528156.v1

Figure S6 from Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Autor: Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3190afcefd6b79b20e3d42188b31395f
https://doi.org/10.1158/1078-0432.22472208.v1

Figure S1 from Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Autor: Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa

Legends included in the figure file

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44eedb3bf2c3aa91f13eca07a31c2347
https://doi.org/10.1158/1078-0432.22472223

Figure S3 from Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Autor: Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa

Legends included in the figure file

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f705d4242bb618c6d145bcd7ffd65
https://doi.org/10.1158/1078-0432.22472217.v1

Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

Autor: Nicolás Luis Calzetta, Vanesa Gottifredi, Natalia S. Paviolo, María Florencia Pansa, María Belén de la Vega, Iris Alejandra García, Gastón Soria

Publikováno v: Genetics and Molecular Biology, Vol 43, Iss 1 suppl 1 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Genetics and Molecular Biology
Genetics and Molecular Biology v.43 n.1 suppl.1 2020
Sociedade Brasileira de Genética (SBG)
instacron:SBG

The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208babc002fa477c194a067d0b31be6e
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200303&tlng=en