Figure S2 from Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Autor: Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa

Legends included in the figure file

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a26ecc52181f0eb97f308f30e83b607
https://doi.org/10.1158/1078-0432.22472220.v1

Table S1 from Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction

Autor: Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa

Full list of hits of the BRCA1-deficient population in the screening performed with the PKIS2 library

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0056d2d9059527e3232a57cd78b0f096
https://doi.org/10.1158/1078-0432.22472202

Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

Autor: Nicolás Luis Calzetta, Vanesa Gottifredi, Natalia S. Paviolo, María Florencia Pansa, María Belén de la Vega, Iris Alejandra García, Gastón Soria

Publikováno v: Genetics and Molecular Biology, Vol 43, Iss 1 suppl 1 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Genetics and Molecular Biology
Genetics and Molecular Biology v.43 n.1 suppl.1 2020
Sociedade Brasileira de Genética (SBG)
instacron:SBG

The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208babc002fa477c194a067d0b31be6e
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200303&tlng=en

Beyond interstrand crosslinks repair: contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA

Autor: Paola B. Campodónico, María Belén Federico, Natalia S. Paviolo, Vanesa Gottifredi

Biallelic mutations of FANCD2 and other components of the Fanconi Anemia (FA) pathway cause a disease characterized by bone marrow failure, cancer predisposition and a striking sensitivity to agents that induce crosslinks between the two complementar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe61d906144a0c44c9ad6554ae48cba
https://www.sciencedirect.com/science/article/pii/S0027510717301148

WITHDRAWN: Beyond interstrand crosslinks repair: Contribution of FANCD2 and other Fanconi Anemia proteins to the replication of DNA

Autor: Paola B. Campodónico, Vanesa Gottifredi, Natalia S. Paviolo, María Belén Federico

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a64b227ef57f269857e24f1f8324d9b
https://doi.org/10.1016/j.mrfmmm.2017.09.006