Safety levels of systemic IL-12 induced by cDNA expression as a cancer therapeutic

Autor: Maria Estefania Viano, Maria Cecilia Rodriguez-Galan, Constanza Savid-Frontera, Natalia S. Baez, Howard A. Young, Della Reynolds, Mariana Matellon

Publikováno v: Immunotherapy

Aim: The aim of this work is to utilize a gene expression procedure to safely express systemic IL-12 and evaluate its effects in mouse tumor models. Materials & methods: Secondary lymphoid organs and tumors from EL4 and B16 tumor-bearing mice were an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fde15d53307fd605233133d6a30ce4
https://doi.org/10.2217/imt-2021-0080

Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of 'innate' characteristics during CD8 + T cell development

Autor: Eva V. Acosta-Rodríguez, Constanza Savid-Frontera, Deborah L. Hodge, Maria Cecilia Rodriguez-Galan, Maria Estefania Viano, Jimena Tosello, Natalia S. Baez, Fabio M. Cerbán, Howard A. Young, Adriana Gruppi, Laura Almada

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 1, p e1007456 (2019)

Innate CD8+ T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in the thymus and depend on IL-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94938b77249997c781dd5495b18e70e1
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007456

Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis

Autor: Samanta Romina Zanetti, Nicolás Fernández Hurst, Cecilia Bouzat, German A. Roth, Mario J. Bibolini, Natalia S. Baez

Publikováno v: Journal of neuroimmunology. 313

Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08675699c76636e025ecea4a83af2358
https://pubmed.ncbi.nlm.nih.gov/28992974

Abrogation of TNFα Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12

Autor: Pablo Iribarren, Natalia S. Baez, Della Reynolds, Maria Cecilia Rodriguez-Galan, Bibiana E. Barrios, Howard A. Young, Hugo Cejas

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 9, Iss 2, p e90116 (2014)
PLoS ONE

For more than a decade, the cytokine interleukin-12 (IL-12) has been utilized, either alone or in combination with otherdrugs, as a treatment for cancer. The numerous anti-tumor properties of IL-12 still generate interest in the clinical use of thisc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0491e4626ffe8c99c45d82f85b48dc4
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090116

Inhibitory role of diazepam on autoimmune inflammation in rats with experimental autoimmune encephalomyelitis

Autor: Mario J. Bibolini, Alicia L. Degano, German A. Roth, Natali L. Chanaday, Clara G. Monferran, Natalia S. Baez

Publikováno v: Neuroscience. 199

Glutamate and GABA are the main excitatory and inhibitory neurotransmitters in the CNS, and both may be involved in the neuronal dysfunction in neurodegenerative conditions. We have recently found that glutamate release was decreased in isolated syna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c0f3d66e998a5ab6f84af64a05175a
https://pubmed.ncbi.nlm.nih.gov/21964471