Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Natalia Rodrigues Mantuano"'
Autor:
Michela Manni, Natalia Rodrigues Mantuano, Andreas Zingg, Elisabeth A. Kappos, Anna-Janina Behrens, Jonathan Back, Rainer Follador, Amir Faridmoayer, Heinz Läubli
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Humans lack the enzyme that produces the sialic acid N-glycolyl neuraminic acid (Neu5Gc), but several lines of evidence have shown that Neu5Gc can be taken up by mammalian food sources and replace the common human sialic acid N-acetyl neuraminic acid
Externí odkaz:
https://doaj.org/article/ad0da400a2bd4a93814c2f64ca1c03f6
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
During oncogenesis, tumor cells present specific carbohydrate chains that are new targets for cancer immunotherapy. Whereas these tumor-associated carbohydrates (TACA) can be targeted with antibodies and vaccination approaches, TACA including sialic
Externí odkaz:
https://doaj.org/article/35092899527340108d5d74438e14546d
Autor:
Andreia eVasconcelos-dos-Santos, Isadora A. Oliveira, Miguel Clodomiro Lucena, Natalia Rodrigues Mantuano, Stephen A. Whelan, Wagner Barbosa Dias, Adriane Regina Todeschini
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the malignant phenotype. The hexosamine biosynthetic pathway (HBP) is a branch of glucose metabolism that produces UDP-GlcNAc, and its derivatives, UDP-GalNAc and CMP-
Externí odkaz:
https://doaj.org/article/35dcb941cd3147b68195bdaf4d17fceb
Autor:
Michal A. Stanczak, Natalia Rodrigues Mantuano, Nicole Kirchhammer, David E. Sanin, Francis Jacob, Ricardo Coelho, Arun V. Everest-Dass, Jinyu Wang, Marcel P. Trefny, Gianni Monaco, Anne Bärenwaldt, Melissa A. Gray, Adam Petrone, Abhishek S. Kashyap, Katharina Glatz, Benjamin Kasenda, Karl Normington, James Broderick, Li Peng, Oliver M.T. Pearce, Erika L. Pearce, Carolyn R. Bertozzi, Alfred Zippelius, Heinz Läubli
Publikováno v:
Science translational medicine : integrating medicine and science / American Association for the Advancement of Science
Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with cancer, but the majority experiences limited benefit, supporting the need for new therapeutic approaches. Up-regulation of sialic acid–containing glycans, te
Autor:
Natalia Rodrigues Mantuano, Elliot C. Woods, Carolyn R. Bertozzi, Heinz Läubli, Payton A. Weidenbacher, Han Xiao, Green Ahn, Stacy A. Malaker, Caitlyn L. Miller, Johan F. A. Pijnenborg, Michal A. Stanczak, Melissa A. Gray, Julia T. Tanzo
Publikováno v:
Nat Chem Biol
Currently approved immune checkpoint inhibitor therapies targeting the PD-1 and CTLA-4 receptor pathways are powerful treatment options for certain cancers; however, most patients across cancer types still fail to respond. Consequently, there is inte
Autor:
Rodrigo Vazquez-Lombardi, Johanna S. Jung, Fabrice S. Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R. Weber, Alfred Zippelius, Heinz Läubli, Sai T. Reddy
Publikováno v:
Immunity, 55 (10)
A major challenge in adoptive T cell immunotherapy is the discovery of natural T cell receptors (TCRs) with high activity and specificity to tumor antigens. Engineering synthetic TCRs for increased tumor antigen recognition is complicated by the risk
Autor:
Isadora A. Oliveira, Alessandra A. Filardy, Alfred Zippelius, Heinz Läubli, César de Souza Bastos, Nicole Kirchhammer, Michal A. Stanczak, Agatha Carlos Fonseca, Ronan Christian Santos, Natalia Rodrigues Mantuano, Gianni Monaco, Adriane R. Todeschini, Wagner B. Dias, Miguel Fontes
Publikováno v:
Cancer immunology research. 8(10)
SummaryDiabetes mellitus (DM) significantly increases the risk for cancer and cancer progression. Hyperglycemia is the defining characteristic of DM and tightly correlates with a poor prognosis in cancer patients. The hexosamine biosynthetic pathway
Autor:
Natalia Rodrigues Mantuano, Miriam Maria Silva Costa, Andre M. Vale, Ana Luiza Szuchmacher Verissimo Lopes, Frederico Alisson-Silva, Andréia Vasconcelos-dos-Santos, Ana Carolina Oliveira, Judy L. Cannon, Adriane R. Todeschini
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence
Autor:
Adriane R. Todeschini, Frederico Alisson-Silva, Wagner B. Dias, Maria Cecilia Oliveira-Nunes, Natalia Rodrigues Mantuano
Publikováno v:
Pharmacological research. 146
Tumors are formed by several cell types interacting in a complex environment of soluble and matrix molecules. The crosstalk between the cells and extracellular components control tumor fate. Macrophages are highly plastic and diverse immune cells tha
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
During oncogenesis, tumor cells present specific carbohydrate chains that are new targets for cancer immunotherapy. Whereas these tumor-associated carbohydrates (TACA) can be targeted with antibodies and vaccination approaches, TACA including sialic