Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

Autor: Christopher M. Murphy, Yanping Xu, Feng Li, Kouki Nio, Natalia Reszka-Blanco, Xiaodong Li, Yaxu Wu, Yanbao Yu, Yue Xiong, Lishan Su

Publikováno v: Cell Reports, Vol 16, Iss 11, Pp 2846-2854 (2016)

The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-t

Externí odkaz: https://doaj.org/article/24b97680d672438894d00608d5cac040

834 Integrin αvβ8 inhibitor improves immune checkpoint therapy in advanced ovarian cancer model and its activity can be monitored in blood

Autor: Natalia Reszka-Blanco, Megan Krumpoch, Huidong Chen, Lia Luus, Michaela Mentzer, Aleksey Molodtsov, Adrian Ray, Vinod Yadav, Matthew Clark, Ian Gerken, Justin Snider, Blaise Lippa, Bruce Rogers, Gerard Bain

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a47b68cabb0ef7eaf23ab2b21ddbebe
https://doi.org/10.1136/jitc-2022-sitc2022.0834

RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin

Autor: Alexander B. Taylor, Vladislav Tsiperson, Borries Demeler, Daniel A. de Souza Aranha Vieira, Felipe Diaz-Griffero, Zinaida Yudina, Dmitri N. Ivanov, Rory Johnson, Nikolaos Biris, Natalia Reszka, Amanda Roa, P. John Hart

Publikováno v: Cell Reports, Vol 12, Iss 5, Pp 788-797 (2015)

Summary Members of the tripartite motif (TRIM) protein family of RING E3 ubiquitin (Ub) ligases promote innate immune responses by catalyzing synthesis of polyubiquitin chains linked through lysine 63 (K63). Here, we investigate the mechanism by whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b669884ede219b48f3494b61798cac3
http://www.sciencedirect.com/science/article/pii/S221112471500710X

Haemonchus contortus: Characterization of the baculovirus expressed form of aminopeptidase H11

Autor: Frans A.M. Rijsewijk, V. Zelnik, Krystyna Bieńkowska-Szewczyk, Natalia Reszka, Bożena Moskwa

Publikováno v: Experimental Parasitology 117 (2007) 2
Experimental Parasitology, 117(2), 208-213

Recombinant form of Haemonchus contortus aminopeptidase H11, an intestinal membrane glycoprotein considered to be in its native form the most promising vaccine candidate, was produced in insect cells, characterised and tested in pilot vaccination-cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bf282b497f16f4df41ac1d13848c3b
https://doi.org/10.1016/j.exppara.2007.03.018

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

Autor: Patricio Perez, Felipe Diaz-Griffero, Maritza Lienlaf, Abraham L. Brass, Jose Carlos Valle-Casuso, Yang Yang, Francesca Di Nunzio, Nathalie J. Arhel, Natalia Reszka

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2012, 86 (10), pp.5931-6. ⟨10.1128/JVI.00451-12⟩
Journal of Virology, 2012, 86 (10), pp.5931-6. ⟨10.1128/JVI.00451-12⟩

TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242af88b8f9701bcd1f549bbcea4c005
https://europepmc.org/articles/PMC3347269/