Výsledky vyhledávání - "Natalia R. Onishchenko"

Akademický článek

Liposomal Formulation of a PLA2-Sensitive Phospholipid–Allocolchicinoid Conjugate: Stability and Activity Studies In Vitro

Autor: Maria K. Kobanenko, Daria S. Tretiakova, Ekaterina S. Shchegravina, Nadezhda V. Antipova, Ivan A. Boldyrev, Alexey Yu. Fedorov, Elena L. Vodovozova, Natalia R. Onishchenko

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 3, p 1034 (2022)

To assess the stability and efficiency of liposomes carrying a phospholipase A2-sensitive phospholipid-allocolchicinoid conjugate (aC-PC) in the bilayer, egg phosphatidylcholine and 1-palmitoyl-2-oleoylphosphatidylglycerol-based formulations were tes

Externí odkaz: https://doaj.org/article/04466fae14a64e3ca184935ff4e9ec6b

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Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions

Autor: Vodovozova, Natalia R. Onishchenko, Alexey A. Moskovtsev, Maria K. Kobanenko, Daria S. Tretiakova, Anna S. Alekseeva, Dmitry V. Kolesov, Anna A. Mikryukova, Ivan A. Boldyrev, Marina R. Kapkaeva, Olga N. Shcheglovitova, Nicolai V. Bovin, Aslan A. Kubatiev, Olga V. Tikhonova, Elena L.

Publikováno v: Pharmaceutics; Volume 15; Issue 6; Pages: 1754

Previously, we showed in the human umbilical vein endothelial cells (HUVECs) model that a liposome formulation of melphalan lipophilic prodrug (MlphDG) decorated with selectin ligand tetrasaccharide Sialyl Lewis X (SiaLeX) undergoes specific uptake b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::d47820424d54a658677fa3a0e69ce0da

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Spotlight on the protein corona of liposomes

Autor: Natalia R. Onishchenko, Elena L. Vodovozova, Daria Tretiakova

Publikováno v: Acta Biomaterialia. 134:57-78

Although an established drug delivery platform, liposomes have not fulfilled their true potential. In the body, interactions of liposomes are mediated by the layer of plasma proteins adsorbed on the surface, the protein corona. The review aims to col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be392836c521fa0a57fe3a8ea6c5c77
https://doi.org/10.1016/j.actbio.2021.07.074

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Liposomal Formulation of a Melphalan Lipophilic Prodrug: Studies of Acute Toxicity, Tolerability, and Antitumor Efficacy

Autor: Alexey Natykan, Elena L. Vodovozova, Natalia R. Onishchenko, Diana Arantseva, Anton Lokhmotov, Ivan A. Boldyrev, Dmitry Shobolov, Elena V. Svirshchevskaya, Daria Tretiakova, Anna Alekseeva, Roman Kamyshinsky

Publikováno v: Current Drug Delivery. 17:312-323

Background:: Recently we developed a scalable scheme of synthesis of melphalan ester conjugate with 1,2-dioleoyl-sn-glycerol (MlphDG) and a protocol for the fabrication of its lyophilized liposomal formulation. Objective: Herein we compared this new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82b4cb3956beee2642281ddd196e0d4
https://doi.org/10.2174/1567201817666200214105357

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Cyclopentane rings in hydrophobic chains of a phospholipid enhance the bilayer stability to electric breakdown

Autor: Timur R. Galimzyanov, Andrey Yu. Chernyadyev, Ivan A. Boldyrev, Oleg V. Batishchev, Natalia R. Onishchenko, Daria Tretiakova, Pavel E. Volynsky, A. S. Alekseeva

Publikováno v: Soft Matter. 16:3216-3223

Archaeal lipids ensure unprecedented stability of archaea membranes in extreme environments. Here, we incorporate a characteristic structural feature of an archaeal lipid, the cyclopentane ring, into hydrocarbon chains of a short-chain (C12) phosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306ad251709072dbdc50127a9788cb3a
https://doi.org/10.1039/c9sm02001b

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Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug

Autor: Elena L. Vodovozova, Daria Tretiakova, Judith Kuntsche, Natalia R. Onishchenko, Elena V. Kudryashova, Irina M. Le-Deigen

Publikováno v: Pharmaceutics, Vol 13, Iss 473, p 473 (2021)
Pharmaceutics
Volume 13
Issue 4
Tretiakova, D, Le-Deigen, I, Onishchenko, N, Kuntsche, J, Kudryashova, E & Vodovozova, E 2021, ' Phosphatidylinositol stabilizes fluid-phase liposomes loaded with a melphalan lipophilic prodrug ', Pharmaceutics, vol. 13, no. 4, 473 . https://doi.org/10.3390/pharmaceutics13040473

Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c93801db89840116e5f8214294b110
https://pubmed.ncbi.nlm.nih.gov/33915726

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Lipophilic Prodrug of Methotrexate in the Membrane of Liposomes Promotes Their Uptake by Human Blood Phagocytes

Autor: Elena L. Vodovozova, Natalia R. Onishchenko, D. C. Tretiakova, I. S. Frolova, O. N. Shcheglovitova, A. A. Babayants, S. V. Khaidukov

Publikováno v: Acta Naturae

Previously, we showed that incorporation of methotrexate (MTX) in the form of a lipophilic prodrug (MTXDG) in 100-nm lipid bilayer liposomes of egg phosphatidylcholine can allow one to reduce toxicity and improve the antitumor efficiency of MTX in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e394dc17bc1488c92a09637278484e36
https://pubmed.ncbi.nlm.nih.gov/32477604

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Behavior of Doxorubicin Lipophilic Conjugates in Liposomal Lipid Bilayers

Autor: Elena L. Vodovozova, Julian G. Molotkovsky, Roman G. Efremov, Anton O. Chugunov, Ivan A. Boldyrev, Natalia R. Onishchenko, A. S. Alekseeva, Pavel E. Volynsky

Publikováno v: Russian Journal of Bioorganic Chemistry. 44:732-739

Preparation of liposomal formulations containing water-soluble drugs in the form of lipophilic prodrugs in their lipid bilayer is of considerable interest. Previously, we synthesized doxorubicin dioleoyl glyceride and oleoyl conjugates intended for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::711e50ea9881faf47a3bda1e8d132840
https://doi.org/10.1134/s1068162019010023

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Interactions of liposomes carrying lipophilic prodrugs in the bilayer with blood plasma proteins

Autor: Natalia R. Onishchenko, Elena L. Vodovozova, A. G. Vostrova, Daria Tretiakova

Publikováno v: Russian Journal of Bioorganic Chemistry. 43:678-689

Interactions of 100-nm liposomes prepared from egg yolk phosphatidylcholine and baker’s yeast phosphatidylinositol carrying diglyceride ester conjugates of melphalan (Mlph-liposomes) and methotrexate (MTX-liposomes) in the bilayer with blood plasma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc58a73111a5ab6d2b38b609d8f74ce1
https://doi.org/10.1134/s1068162017060139

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