Influence of individuals’ determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination

Autor: Emma S. Chambers, Weigang Cai, Giulia Vivaldi, David A. Jolliffe, Natalia Perdek, Wenhao Li, Sian E. Faustini, Joseph M. Gibbons, Corinna Pade, Alex G. Richter, Anna K. Coussens, Adrian R. Martineau

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)

Abstract Vaccine development targeting SARS-CoV-2 in 2020 was of critical importance in reducing COVID-19 severity and mortality. In the U.K. during the initial roll-out most individuals either received two doses of Pfizer COVID-19 vaccine (BNT162b2)

Externí odkaz: https://doaj.org/article/2bf8b9f303d3489cb53fdb91aa74388d

Determinants of Antibody Responses to SARS-CoV-2 Vaccines: Population-Based Longitudinal Study (COVIDENCE UK)

Autor: David A. Jolliffe, Sian E. Faustini, Hayley Holt, Natalia Perdek, Sheena Maltby, Mohammad Talaei, Matthew Greenig, Giulia Vivaldi, Florence Tydeman, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Seif O. Shaheen, Alex G. Richter, Adrian R. Martineau

Publikováno v: Vaccines, Vol 10, Iss 10, p 1601 (2022)

Antibody responses to SARS-CoV-2 vaccines vary for reasons that remain poorly understood. A range of sociodemographic, behavioural, clinical, pharmacologic and nutritional factors could explain these differences. To investigate this hypothesis, we te

Externí odkaz: https://doaj.org/article/6ecab6ed88594c469e61463d03cf769b

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)

Autor: David A Jolliffe, Hayley Holt, Matthew Greenig, Mohammad Talaei, Natalia Perdek, Paul Pfeffer, Giulia Vivaldi, Sheena Maltby, Jane Symons, Nicola L Barlow, Alexa Normandale, Rajvinder Garcha, Alex G Richter, Sian E Faustini, Christopher Orton, David Ford, Ronan A Lyons, Gwyneth A Davies, Frank Kee, Christopher J Griffiths, John Norrie, Aziz Sheikh, Seif O Shaheen, Clare Relton, Adrian R Martineau

Publikováno v: Jolliffe, D A, Holt, H, Greenig, M, Talaei, M, Perdek, N, Pfeffer, P, Vivaldi, G, Maltby, S, Symons, J, Barlow, N L, Normandale, A, Garcha, R, Richter, A G, Faustini, S E, Orton, C, Ford, D, Lyons, R A, Davies, G A, Kee, F, Griffiths, C J, Norrie, J, Sheikh, A, Shaheen, S O, Relton, C & Martineau, A R 2022, ' Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19 : phase 3 randomised controlled trial (CORONAVIT) ', BMJ (Clinical research ed.), vol. 378, 071230, pp. e071230 . https://doi.org/10.1136/bmj-2022-071230
Jolliffe, D A, Holt, H, Greenig, M, Talaei, M, Perdek, N, Pfeffer, P, Vivaldi, G, Maltby, S, Symons, J, Barlow, N L, Normandale, A, Garcha, R, Richter, A G, Faustini, S E, Orton, C, Ford, D, Lyons, R A, Davies, G A, Kee, F, Griffiths, C J, Norrie, J, Sheikh, A, Shaheen, S O, Relton, C & Martineau, A R 2022, ' Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT) ', BMJ, vol. 378, e071230 . https://doi.org/10.1136/bmj-2022-071230

ObjectiveTo determine the effect of population level implementation of a test-and-treat approach to correction of suboptimal vitamin D status (25-hydroxyvitamin D (25(OH)D) DesignPhase 3 open label randomised controlled trial.SettingUnited Kingdom.Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dad49bfbd33c1034ec6e1d3c8afe3e
https://pubmed.ncbi.nlm.nih.gov/36215226

Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK)

Autor: Giulia Vivaldi, David A Jolliffe, Sian Faustini, Hayley Holt, Natalia Perdek, Mohammad Talaei, Florence Tydeman, Emma S Chambers, Weigang Cai, Wenhao Li, Joseph M Gibbons, Corinna Pade, Áine McKnight, Seif O Shaheen, Alex G Richter, Adrian R Martineau

In this population-based cohort of 7530 adults, combined IgG/A/M anti-Spike titres measured after SARS-CoV-2 vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::972e5cdd2d43368299b371a678e590ba
https://doi.org/10.1101/2022.02.11.22270667

Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK)

Autor: Mohammad Talaei, Sian Faustini, Hayley Holt, David A. Jolliffe, Giulia Vivaldi, Matthew Greenig, Natalia Perdek, Sheena Maltby, Carola M Bigogno, Jane Symons, Gwyneth A Davies, Ronan A Lyons, Christopher J Griffiths, Frank Kee, Aziz Sheikh, Alex G Richter, Seif O Shaheen, Adrian R Martineau

Publikováno v: Talaei, M, Faustini, S, Holt, H, Jolliffe, D A, Vivaldi, G, Greenig, M, Perdek, N, Maltby, S, Bigogno, C M, Symons, J, Davies, G A, Lyons, R A, Griffiths, C J, Kee, F, Sheikh, A, Richter, A G, Shaheen, S O & Martineau, A R 2022, ' Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK) ', BMC Medicine, vol. 20, 87 . https://doi.org/10.1186/s12916-022-02286-4
Talaei, M, Faustini, S, Holt, H, Jolliffe, D A, Vivaldi, G, Greenig, M, Perdek, N, Maltby, S, Bigogno, C M, Symons, J, Davies, G A, Lyons, R A, Griffiths, C J, Kee, F, Sheikh, A, Richter, A G, Shaheen, S O & Martineau, A R 2022, ' Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK) ', BMC Medicine, vol. 20, no. 1, 87 . https://doi.org/10.1186/s12916-022-02286-4

BackgroundProspective population-based studies investigating multiple determinants of pre-vaccination antibody responses to SARS-CoV-2 are lacking.MethodsWe did a prospective population-based study in SARS-CoV-2 vaccine-naive UK adults recruited betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c964caaecdaec2f526f1225e44d706c9
https://pubmed.ncbi.nlm.nih.gov/35189888