A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Autor: Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB a

Externí odkaz: https://doaj.org/article/7575acc4586f44568954b0510de1f6d3

In Vivo Secretion of Bispecific Antibodies Recruiting Lymphocytic Effector Cells

Autor: Luis Alvarez-Vallina, Laura Sanz, Natalia Nuñez-Prado, Marta Compte

Publikováno v: Antibodies, Vol 2, Iss 3, Pp 415-425 (2013)

Engineered Fc-lacking bispecific antibodies have shown an exceptionally high potency for recruiting lymphocyte effector cells and enhancing antitumor activity, which is under evaluation in several clinical trials. However, current treatment regimens

Externí odkaz: https://doaj.org/article/bc8ca2fef5dc4b39848adf954f75f152

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Autor: Ángel M. Cuesta, Eduardo Caleiras, Francisco J. Blanco, Inés G. Muñoz, Jorge Bernardino de la Serna, M. Angela Aznar, Ainhoa Erce-Llamazares, Ignacio Melero, Natalia Nuñez-Prado, Manuela Zonca, Antonio Tapia-Galisteo, Jorge L. Martínez-Torrecuadrada, Simon Lykkemark, Juan M. Zapata, Gema Perez-Chacon, Nekane Merino, Marta Compte, Laura Sanz, Seandean Lykke Harwood, Luis Álvarez-Vallina, Kasper Mikkelsen, Rocío Navarro

Publikováno v: Compte, M, Harwood, S L, Muñoz, I G, Navarro, R, Zonca, M, Perez-Chacon, G, Erce-Llamazares, A, Merino, N, Tapia-Galisteo, A, Cuesta, A M, Mikkelsen, K, Caleiras, E, Nuñez-Prado, N, Aznar, M A, Lykkemark, S, Martínez-Torrecuadrada, J, Melero, I, Blanco, F J, Bernardino de la Serna, J, Zapata, J M, Sanz, L & Alvarez-Vallina, L 2018, ' A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity ', Nature Communications, vol. 9, 4809 . https://doi.org/10.1038/s41467-018-07195-w
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dadun. Depósito Académico Digital de la Universidad de Navarra
Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

The costimulation of immune cells using first-generation anti-4-1BB monoclonal antibodies (mAbs) has demonstrated anti-tumor activity in human trials. Further clinical development, however, is restricted by significant off-tumor toxicities associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09562925fba8990ef24114a61c62ca0c
https://pure.au.dk/ws/files/145283326/s41467_018_07195_w.pdf

Balanced secretion of anti-CEA x anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

Autor: Laura Sanz, Seandean Lykke Harwood, Marta Compte, Luis Álvarez-Vallina, Kasper Mølgaard, Natalia Nuñez-Prado

Publikováno v: Mølgaard, K, Compte, M, Alanes, N N D P, Harwood, S L, Sanz, L & Álvarez-Vallina, L 2017, ' Balanced secretion of anti-CEA x anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity ', Gene Therapy, vol. 24, pp. 208-214 . https://doi.org/10.1038/gt.2017.3
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Gene Therapy

Adoptive transfer of genetically engineered human cells secreting bispecific T-cell engagers has shown encouraging therapeutic effects in preclinical models of cancer. However, reducing the toxicity and improving the effectiveness of this emerging im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9d7ab8b185c19b8fdec5bb5d707e60
https://pure.au.dk/portal/da/publications/balanced-secretion-of-anticea-x-anticd3-diabody-chains-using-the-2a-selfcleaving-peptide-maximizes-diabody-assembly-and-tumorspecific-cytotoxicity(8eae72ce-5553-49ca-b11f-343d6706faea).html

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

Autor: Ángel M. Cuesta, Maider Villate, Laura Sanz, Francisco J. Blanco, Marta Compte, Nekane Merino, Kasper Mølgaard, Luis Álvarez-Vallina, Baldo Oliva, Natalia Nuñez-Prado, Jaume Bonet, Ana Blanco-Toribio, Ana Álvarez-Cienfuegos, Rocío Navarro, Seandean Lykke Harwood, Clara Muñoz-Briones, Karen Marie Juul Sørensen

Publikováno v: Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
Álvarez-Cienfuegos, A, Alanes, N N D P, Compte, M, Cuesta, À M, Blanco-Toribio, A, Harwood, S L, Villate, M, Merino, N, Bonet, J, Navarro, R, Muñoz-Briones, C, Sørensen, K M J, Mølgaard, K, Oliva, B, Sanz, L, Blanco, F J & Álvarez-Vallina, L 2016, ' Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains ', Scientific Reports, vol. 6, 28643 . https://doi.org/10.1038/srep28643

Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human coll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24821cd1ae0969e7830a8f2ff29ae33a
https://pubmed.ncbi.nlm.nih.gov/27345490