Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Natalia Nekhotiaeva"'
Autor:
Anniina T. Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen, Jianping Liu, Natalia Nekhotiaeva, Stevan R. Hubbard, Olli Silvennoinen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 75 (2023)
Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical
Externí odkaz:
https://doaj.org/article/6cfdba99ff324992a07f46b8c564e944
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Autor:
Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna Green, Karl Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith Unterlass, Martin Haraldsson, Yasmin Andersson, Emma Scaletti, Christoffer Bengtsson, Cynthia Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans Krokan, Per Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert Homan, Thomas Helleday
Supplementary methods for the article "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032514cb5181fdda8fdfefd73848c5d0
https://doi.org/10.21203/rs.3.pex-1730/v1
https://doi.org/10.21203/rs.3.pex-1730/v1
Autor:
Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O. Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J. Craig, Yoseph Atilaw, Anja Sandström, Lindon W. K. Moodie, Åke Lundkvist, Martijn J. van Hemert, Johan Neyts, Johan Lennerstrand, Jan Kihlberg, Kristian Sandberg, U. Helena Danielson, Jens Carlsson
Publikováno v:
Journal of the American Chemical Society, 144(7), 2905-2920. AMER CHEMICAL SOC
Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946c3c3e10aa0c690988b970c049d161
http://hdl.handle.net/1887/3479854
http://hdl.handle.net/1887/3479854
Autor:
Lina Wik Leiss, Per Øyvind Enger, Daniel Hägerstrand, Linda Sleire, Mette Hartmark Nilsen, Carina Strell, Alessandro Mega, Arne Östman, Jianping Liu, Sven Nelander, Anders Eriksson, Cecilia Krona, Nicholas P. Tobin, Natalia Nekhotiaeva, Monica Nistér, Lene Uhrbom
Publikováno v:
Neuro-Oncology. 20:vi263-vi264
Glioblastoma multiforme (GBM) is a disease with an urgent need for deeper understanding and new therapeutic approaches. As in other solid tumors, the tumor microenvironment (TME) is likely to control growth and sensitivity to treatment. Key component
Autor:
Per-Johan Jakobsson, Natalia Nekhotiaeva, Linda Spahiu, Marina Korotkova, Charlotte Larsson, Helena Idborg, Patrick Leclerc, Patric Stenberg, Johan Wannberg
Publikováno v:
Prostaglandins & Other Lipid Mediators. 107:26-34
Microsomal prostaglandin E synthase-1 (mPGES-1) inhibition has been suggested as an alternative to cyclooxygenase (COX) inhibition in the treatment of pain and inflammation. We characterized a selective inhibitor of mPGES-1 activity (compound III) an
Autor:
Linda Spahiu, Ralf Morgenstern, Patric Stenberg, Johan Wannberg, Charlotte Larsson, Björn Kull, Mathias Alterman, Natalia Nekhotiaeva
Publikováno v:
ASSAY and Drug Development Technologies. 9:487-495
Microsomal prostaglandin E(2) synthase-1 (MPGES1) catalyzes the formation of prostaglandin E(2) from the endoperoxide prostaglandin H(2). MPGES1 expression is induced in inflammatory diseases, and this enzyme is regarded as a potential drug target. T
Publikováno v:
Journal of Antimicrobial Chemotherapy. 56:97-103
BACKGROUND The few available distinct classes of antimicrobials limits the scope for single and combination drug treatment of resistant infections. OBJECTIVE To evaluate antimicrobial effectiveness from combinations of protein-specific drugs and mRNA
Publikováno v:
Microbial Physiology. 9:101-109
Antisense agents that inhibit genes at the mRNA level are attractive tools for genome-wide studies and drug target validation. The approach may be particularly well suited to studies of bacteria that are difficult to manipulate with standard genetic
Autor:
Liam Good, Gunaratna Kuttuva Rajarao, Mattias Hällbrink, Natalia Nekhotiaeva, Anna Elmquist, Ülo Langel
Publikováno v:
The FASEB Journal. 18:1-15
Antimicrobial drug action is limited by both microbial and host cell membranes. Microbes stringently exclude the entry of most drugs, and mammalian membranes limit drug distribution and access to intracellular pathogens. Recently, cell-penetrating pe