Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Natalia N. Shestakova"'
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
N-methyl-D-aspartate receptors (NMDARs) are an essential target for the analgetic action of tricyclic antidepressants (TCAs). Their therapeutic blood concentrations achieve 0.5–1.5 μM, which, however, are insufficient to cause in vitro the open-ch
Externí odkaz:
https://doaj.org/article/7b363b8ad4da4ed4a0729c6f475c0349
Autor:
Daria A. Belinskaia, Mariia A. Belinskaia, Oleg I. Barygin, Nina P. Vanchakova, Natalia N. Shestakova
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 99 (2019)
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvuls
Externí odkaz:
https://doaj.org/article/674ecd84b79d424cb876559961bb53fd
Autor:
Rajnish Kumar, Natalia N. Shestakova, Daria A. Belinskaia, Shivani Vaidya, Vinod Tiwari, Ankit Uniyal, Sanjay Singh, P. A. Shantanu
Publikováno v:
ACS Chemical Neuroscience. 12:1948-1960
Kinesins are the motor proteins that transport excitatory receptors to the synaptic membrane by forming a complex with receptor cargo leading to central sensitization causing neuropathic pain. Many regulatory proteins govern the transit of receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8f548bce7bbbeb5f5ca8bcbaffb384
https://doi.org/10.1021/acschemneuro.1c00043
https://doi.org/10.1021/acschemneuro.1c00043
Publikováno v:
Journal of Evolutionary Biochemistry and Physiology. 57:694-703
Tricyclic antidepressants, specifically amitriptyline (ATL) and desipramine (DES) are currently used to treat depression and chronic pain of various origins, in which NMDA receptor dysfunctions play an important role. The effect of therapeutic ATL co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b1568eb2139c1dd18079c428377336
https://doi.org/10.1134/s0022093021030169
https://doi.org/10.1134/s0022093021030169
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
N-methyl-D-aspartate receptors (NMDARs) are an essential target for the analgetic action of tricyclic antidepressants (TCAs). Their therapeutic blood concentrations achieve 0.5–1.5 μM, which, however, are insufficient to cause in vitro the open-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459726349dd9c52e2a3babf2800c2b76
https://pubmed.ncbi.nlm.nih.gov/35237149
https://pubmed.ncbi.nlm.nih.gov/35237149
Autor:
Sneha Shaw, Pran Kishore Deb, Vinod K. Tiwari, Ankit Uniyal, Daria A. Belinskaia, Anagha Gadepalli, Katharigatta N. Venugopala, Vineeta Tiwari, Natalia N. Shestakova
Publikováno v:
European journal of pharmacology. 889
Neuropathic pain is a critical burdensome problem due to the complex interplay of several pathological mechanisms and lack of availability of effective therapeutic interventions. The available therapeutic options are associated with a variety of limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbdb1b7937b293442e363abd3eed49e
https://pubmed.ncbi.nlm.nih.gov/33011242
https://pubmed.ncbi.nlm.nih.gov/33011242
Autor:
Elina I. Nagaeva, Nina P. Vanchakova, Oleg I. Barygin, Darya A. Belinskaya, Natalia N. Shestakova, Denis B. Tikhonov
Publikováno v:
Brain Research. 1660:58-66
It is known that some antidepressants and antipsychotics directly inhibit NMDA-type ionotropic glutamate receptors. In this study we systematically studied action of seven drugs (Fluoxetine, Citalopram, Desipramine, Amitriptyline, Atomoxetine, Chlorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0d4441f43fc0c06672c8442b8039d3
https://doi.org/10.1016/j.brainres.2017.01.028
https://doi.org/10.1016/j.brainres.2017.01.028
Autor:
Natalia N. Shestakova, Sergei I. Boikov, P. A. Abushik, Daria A. Belinskaia, Yulia D. Stepanenko, D. A. Sibarov, Nina Pavlovna Vanchakova, Sergei M. Antonov
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Although the tricyclic antidepressant amitriptyline (ATL) is widely used in the clinic, the mechanism underlying its high therapeutic efficacy against neuropathic pain remains unclear. NMDA receptors (NMDARs) represent a target for ATL and are involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056e54ca1dadfd50240e7b324414ee2b
https://pubmed.ncbi.nlm.nih.gov/31857688
https://pubmed.ncbi.nlm.nih.gov/31857688
Autor:
Nina P. Vanchakova, Daria A. Belinskaia, Oleg I. Barygin, Natalia N. Shestakova, Mariia A. Belinskaia
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 99 (2019)
Pharmaceuticals
Pharmaceuticals
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvuls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1549874d0ffa9dd52c97eb98027cc801
https://www.mdpi.com/1424-8247/12/2/99
https://www.mdpi.com/1424-8247/12/2/99
Autor:
Nina Pavlovna Vanchakova, Yu. D. Stepanenko, Sergei M. Antonov, Natalia N. Shestakova, D. A. Sibarov, S. I. Boykov, D. A. Belinskaya
Publikováno v:
Журнал эволюционной биохимии и физиологии. 56:797-797
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ed58d7ae9c198507b56b270308a311
https://doi.org/10.31857/s0044452920072607
https://doi.org/10.31857/s0044452920072607