Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Natalia Martínez-Pomar"'
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Akademický článek
Hyperinflammatory Immune Response in COVID-19: Host Genetic Factors in Pyrin Inflammasome and Immunity to Virus in a Spanish Population from Majorca Island
Autor: Natalia Martínez-Pomar, Vanesa Cunill, Marina Segura-Guerrero, Elisabet Pol-Pol, Danilo Escobar Oblitas, Jaime Pons, Ignacio Ayestarán, Patricia C. Pruneda, Inés Losada, Nuria Toledo-Pons, Mercedes García Gasalla, Joana Maria Ferrer Balaguer
Publikováno v: Biomedicines, Vol 11, Iss 9, p 2548 (2023)
The hyperinflammatory response caused by SARS-CoV-2 infection contributes to its severity, and many critically ill patients show features of cytokine storm (CS) syndrome. We investigated, by next-generation sequencing, 24 causative genes of primary i
Externí odkaz: https://doaj.org/article/3ebc29bcdc924933843a4a2ed7708723
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2
Akademický článek
Hyperinflammatory State and Low T1 Adaptive Immune Response in Severe and Critical Acute COVID-19 Patients
Autor: Mercedes Garcia-Gasalla, María Berman-Riu, Jaime Pons, Adrián Rodríguez, Amanda Iglesias, Natalia Martínez-Pomar, Isabel Llompart-Alabern, Melchor Riera, Adrián Ferré Beltrán, Albert Figueras-Castilla, Javier Murillas, Joana M. Ferrer
Publikováno v: Frontiers in Medicine, Vol 9 (2022)
BackgroundA better understanding of COVID-19 immunopathology is needed to identify the most vulnerable patients and improve treatment options.ObjectiveWe aimed to identify immune system cell populations, cytokines, and inflammatory markers related to
Externí odkaz: https://doaj.org/article/43cadb821502443bbbdbe4a144f4711c
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3
Akademický článek
Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission
Autor: Mercedes García-Gasalla, Juana M. Ferrer, Pablo A. Fraile-Ribot, Adrián Ferre-Beltrán, Adrián Rodríguez, Natalia Martínez-Pomar, Luisa Ramon-Clar, Amanda Iglesias, Inés Losada-López, Francisco Fanjul, Joan Albert Pou, Isabel Llompart-Alabern, Nuria Toledo, Jaime Pons, Antonio Oliver, Melchor Riera, Javier Murillas
Publikováno v: Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2021 (2021)
Background. Early identification of COVID-19 patients at risk of critical illness is a challenging endeavor for clinicians. We aimed to establish immunological, virological, and routine laboratory markers, which, in combination with clinical informat
Externí odkaz: https://doaj.org/article/93915232cdf24aaf9da6c04a58dbd879
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4
Unexpected relevant role of gene mosaicism in patients with primary immunodeficiency diseases
Autor: Laia Alsina, José Carlos Rodríguez-Gallego, Pere Soler-Palacín, Weng Tarng Cham, Enrique Gómez de la Fuente, Rebeca Rodríguez-Pena, Jordi Yagüe, Luis Ignacio Gonzalez-Granado, José M. Morales, Osvaldo M. Mutchinick, Roger Colobran, Luz Yadira Bravo Gallego, Angélica Balderrama-Rodríguez, Alejandro Souto, Pablo Mesa-del-Castillo, María Bravo García-Morato, Kieron S. Leslie, Consuelo Modesto, Juan I. Aróstegui, Naouel Guirat Dhouib, María Teresa Martínez-Saavedra, Carine Wouters, Catalina Mosquera, Marketa Bloomfield, María Teresa Bosque, Maria Teresa Terreri, Daniel Clemente, Jeronima Cañellas, Natalia Palmou, Eva González-Roca, Josep M. Campistol, Lívia Almeida Dutra, Cecilia Gonzalez-Santesteban, Eduardo Ramos, Eduardo López-Granados, Ferran Casals, Norberto Ortego-Centeno, Jose Luis Fuster, Luis M. Allende, Jaime de Inocencio, Mohamed Bejaoui, Laura Martínez-Martínez, Clara Franco-Jarava, Anna Mensa-Vilaro, Santiago Jimenez-Treviño, Rebeca Pérez de Diego, Oscar de la Calle-Martin, Agustin Remesal, Tatiana González, Natalia Martínez-Pomar
Publikováno v: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
BACKGROUND: Postzygotic de novo mutations lead to the phenomenon of gene mosaicism. The 3 main types are called somatic, gonadal, and gonosomal mosaicism, which differ in terms of the body distribution of postzygotic mutations. Mosaicism has been rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5148ee8b2b5d7f2956f8f0da6cb396e7
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15122
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6
Costimulatory Molecules and Cytokine Production by T Lymphocytes in Common Variable Immunodeficiency Disease
Autor: Jaume Pons, J. Iglesias-Alzueta, Natalia Martínez-Pomar, Núria Matamoros, J. M. Ferrer
Publikováno v: Scandinavian Journal of Immunology. 63:383-389
Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by hypogammaglobulinaemia and recurrent infections. Although early works pointed to a primary B-lymphocyte defect as a cause of the disease, a failure in T-lymphocyte c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0979a95282aed24c0873c9ae42706a10
https://doi.org/10.1111/j.1365-3083.2006.01753.x
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7
Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-γ gene
Autor: S. Raga, Jaume Ferrer, I. Munoz‐Saa, Jaume Pons, Núria Matamoros, Natalia Martínez-Pomar, J. De Gracia, M.‐R. Julia
Publikováno v: Clinical and Experimental Immunology. 144:233-238
SummaryCommon variable immunodeficiency disease (CVID) is a heterogeneous syndrome characterized by low immunoglobulin serum levels and recurrent bacterial infections. Several studies suggest that CVID patients have a polarized immune response toward
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce127d75e82214745b496e73d5f2c328
https://doi.org/10.1111/j.1365-2249.2006.03063.x
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9
TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes
Autor: Mónica Martínez-Gallo, Charlotte Cunningham-Rundles, Natalia Martínez-Pomar, María Belén Almejún, Núria Matamoros, Lin Radigan
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Mutations in the gene coding for the transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) are found in 8% to 10% of subjects with common variable immunodeficiency (CVID). Although heterozygous mutations may coincide wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffbafdecb2c18629a17edec07ccbc27
http://www.jacionline.org/article/S0091-6749(12)01697-1/abstract
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10
Functional impact of A91V mutation of the PRF1 perforin gene
Autor: Núria Matamoros, Neus Romo, Miguel López-Botet, Natalia Martínez-Pomar, Nallibe Lanio
Publikováno v: Human immunology. 74(1)
Perforin (PRF1) gene mutations have been associated with Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2). Substitution p.A91V (c.272C>T) in exon 2 was first described as a neutral polymorphism. Nonetheless, recent clinical evidence and func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ea52c5b1a4acf89102527cf7ecc85b
https://pubmed.ncbi.nlm.nih.gov/23073290
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