Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Natalia Malikowska"'
1
Akademický článek
Deep learning algorithms reveal increased social activity in rats at the onset of the dark phase of the light/dark cycle.
Autor: Piotr Popik, Ewelina Cyrano, Joanna Golebiowska, Natalia Malikowska-Racia, Agnieszka Potasiewicz, Agnieszka Nikiforuk
Publikováno v: PLoS ONE, Vol 19, Iss 11, p e0307794 (2024)
The rapid decrease of light intensity is a potent stimulus of rats' activity. The nature of this activity, including the character of social behavior and the composition of concomitant ultrasonic vocalizations (USVs), is unknown. Using deep learning
Externí odkaz: https://doaj.org/article/036f0cc0d59649d89c353a8fa03192a7
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2
Akademický článek
Effects of ketamine on rat social behavior as analyzed by DeepLabCut and SimBA deep learning algorithms
Autor: Piotr Popik, Ewelina Cyrano, Diana Piotrowska, Malgorzata Holuj, Joanna Golebiowska, Natalia Malikowska-Racia, Agnieszka Potasiewicz, Agnieszka Nikiforuk
Publikováno v: Frontiers in Pharmacology, Vol 14 (2024)
Traditional methods of rat social behavior assessment are extremely time-consuming and susceptible to the subjective biases. In contrast, novel digital techniques allow for rapid and objective measurements. This study sought to assess the feasibility
Externí odkaz: https://doaj.org/article/be7c51615a5846f184bc09f5d99008ac
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3
Akademický článek
Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD
Autor: Natalia Malikowska-Racia, Kinga Salat, Joanna Gdula-Argasinska, Piotr Popik
Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Posttraumatic stress disorder (PTSD) has been associated with abnormal regulation of the hypothalamic-pituitary-adrenal gland axis (HPA). Women demonstrate a more robust HPA response and are twice as likely to develop PTSD than men. The role of sex h
Externí odkaz: https://doaj.org/article/1fcd0e0f6d2344759f53d7d112e853c0
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4
Akademický článek
Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors
Autor: Kinga Sałaciak, Natalia Malikowska-Racia, Klaudia Lustyk, Agata Siwek, Monika Głuch-Lutwin, Grzegorz Kazek, Justyna Popiół, Jacek Sapa, Henryk Marona, Dorota Żelaszczyk, Karolina Pytka
Publikováno v: Pharmaceuticals, Vol 14, Iss 8, p 744 (2021)
The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates
Externí odkaz: https://doaj.org/article/ffe77bfce64941849e5dbfd0d2020f70
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5
Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
Autor: Piotr Popik, Adam Hogendorf, Ryszard Bugno, Shaun Yon-Seng Khoo, Pawel Zajdel, Natalia Malikowska-Racia, Agnieszka Nikiforuk, Joanna Golebiowska
Publikováno v: Psychopharmacology. 239:1689-1703
Rationale Ketamine and psilocybin belong to the rapid-acting antidepressants but they also produce psychotomimetic effects including timing distortion. It is currently debatable whether these are essential for their therapeutic actions. As depressed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450b113e62f191bb5c3d6b825618693f
https://doi.org/10.1007/s00213-021-06020-5
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6
Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties
Autor: Maciej Pawłowski, Xavier Bantreil, Natalia Malikowska-Racia, Ryszard Bugno, Joanna Golebiowska, Jean Martinez, Frédéric Lamaty, Séverine Chaumont-Dubel, Gilles Subra, Paweł Zajdel, Grzegorz Satała, Piotr Popik, Katarzyna Grychowska, Andrzej J. Bojarski, Philippe Marin, Szczepan Mogilski, Rafał Kurczab, Agnieszka Nikiforuk, Tomasz Kos
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
International audience; In line with recent clinical trials demonstrating that ondansetron, a 5-HT3 receptor (5-HT3R) antagonist, ameliorates cognitive deficits of schizophrenia and the known procognitive effects of 5-HT6 receptor (5-HT6R) antagonist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15083ae33bd02cc6bfdb1887e45a13ff
http://europepmc.org/articles/PMC8474115
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7
Effects of ketamine optical isomers, fluoxetine and naloxone on timing in differential reinforcement of low-rate response (DRL) 72-s task in rats
Autor: Natalia Malikowska-Racia, Joanna Golebiowska, Agnieszka Nikiforuk, Shaun Yon-Seng Khoo, Piotr Popik
Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 67
(S)-ketamine-induced rapid-acting antidepressant effects have revolutionized the pharmacotherapy of major depression; however, this medication also produces psychotomimetic effects such as timing distortion. While (R)-ketamine produces fewer dissocia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2003c117f4c2d97213c561ccfb0817a
https://pubmed.ncbi.nlm.nih.gov/36476352
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9
Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors
Autor: Grzegorz Kazek, Henryk Marona, Karolina Pytka, Dorota Żelaszczyk, Jacek Sapa, Natalia Malikowska-Racia, Justyna Popiół, Agata Siwek, Kinga Sałaciak, Klaudia Lustyk, Monika Głuch-Lutwin
Publikováno v: Pharmaceuticals, Vol 14, Iss 744, p 744 (2021)
Pharmaceuticals
Volume 14
Issue 8
The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d2fac1600bedac03d84c32c761b47
https://www.mdpi.com/1424-8247/14/8/744
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10
Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD
Autor: Piotr Popik, Joanna Gdula-Argasińska, Natalia Malikowska-Racia, Kinga Sałat
Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Posttraumatic stress disorder (PTSD) has been associated with abnormal regulation of the hypothalamic-pituitary-adrenal gland axis (HPA). Women demonstrate a more robust HPA response and are twice as likely to develop PTSD than men. The role of sex h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bde19594cb3c5630ab0e32f5a15e0a6
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